Palindromic Rheumatism: Just a Pre-rheumatoid Stage or Something Else?
Palindromic rheumatism (PR), a unique clinical entity, has a characteristic clinical presentation with a relapsing/remitting course. It is established that most patients with PR evolve to chronic disease, of which rheumatoid arthritis (RA) is by far the most common. The relationship between PR and R...
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doaj-51eac56a54db44a3894a81e337c753f52021-03-25T04:56:07ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2021-03-01810.3389/fmed.2021.657983657983Palindromic Rheumatism: Just a Pre-rheumatoid Stage or Something Else?Raimon Sanmartí0Beatriz Frade-Sosa1Rosa Morlà2Raul Castellanos-Moreira3Sonia Cabrera-Villalba4Sonia Cabrera-Villalba5Julio Ramirez6Georgina Salvador7Isabel Haro8Juan D. Cañete9Arthritis Unit, Rheumatology Service, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Hospital Clinic de Barcelona, Barcelona, SpainArthritis Unit, Rheumatology Service, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Hospital Clinic de Barcelona, Barcelona, SpainArthritis Unit, Rheumatology Service, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Hospital Clinic de Barcelona, Barcelona, SpainArthritis Unit, Rheumatology Service, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Hospital Clinic de Barcelona, Barcelona, SpainHospital Central del Instituto de Previsión Social, Asunción, ParaguayHospital de Clínicas Universidad Nacional de Asunción, Asunción, ParaguayArthritis Unit, Rheumatology Service, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Hospital Clinic de Barcelona, Barcelona, SpainRheumatology Department, University Hospital Mutua Tarrasa, Barcelona, SpainUnit of Synthesis and Biomedical Applications of Peptides, Institute of Advanced Chemistry of Catalonia, Consejo Superior de Investigaciones Científicas (IQAC-CSIC), Barcelona, SpainArthritis Unit, Rheumatology Service, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Hospital Clinic de Barcelona, Barcelona, SpainPalindromic rheumatism (PR), a unique clinical entity, has a characteristic clinical presentation with a relapsing/remitting course. It is established that most patients with PR evolve to chronic disease, of which rheumatoid arthritis (RA) is by far the most common. The relationship between PR and RA is unclear, with similarities and differences between the two, and not all patients evolve to RA in the long-term. Therefore, PR is clearly a pre-RA stage for most, but not all, patients. Autoimmunity plays a substantial role in PR, with the same characteristic autoantibody profile observed in RA, although with some differences in the immune response repertoire. Autoinflammation may also be relevant in some cases of PR. Prognostic factors for RA progression are identified but their exact predictive value is not clear. There are several unmet needs in PR, such as the diagnostic criteria and clinical case definition, the pathogenic mechanisms involved in the unusual clinical course, and the evolution to RA, and our understanding of the therapeutic strategy that could best avoid progression to persistent and potentially destructive arthritis.https://www.frontiersin.org/articles/10.3389/fmed.2021.657983/fullpalindromic rheumatismrheumatoid arthritisACPApre-RAmanagement |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Raimon Sanmartí Beatriz Frade-Sosa Rosa Morlà Raul Castellanos-Moreira Sonia Cabrera-Villalba Sonia Cabrera-Villalba Julio Ramirez Georgina Salvador Isabel Haro Juan D. Cañete |
spellingShingle |
Raimon Sanmartí Beatriz Frade-Sosa Rosa Morlà Raul Castellanos-Moreira Sonia Cabrera-Villalba Sonia Cabrera-Villalba Julio Ramirez Georgina Salvador Isabel Haro Juan D. Cañete Palindromic Rheumatism: Just a Pre-rheumatoid Stage or Something Else? Frontiers in Medicine palindromic rheumatism rheumatoid arthritis ACPA pre-RA management |
author_facet |
Raimon Sanmartí Beatriz Frade-Sosa Rosa Morlà Raul Castellanos-Moreira Sonia Cabrera-Villalba Sonia Cabrera-Villalba Julio Ramirez Georgina Salvador Isabel Haro Juan D. Cañete |
author_sort |
Raimon Sanmartí |
title |
Palindromic Rheumatism: Just a Pre-rheumatoid Stage or Something Else? |
title_short |
Palindromic Rheumatism: Just a Pre-rheumatoid Stage or Something Else? |
title_full |
Palindromic Rheumatism: Just a Pre-rheumatoid Stage or Something Else? |
title_fullStr |
Palindromic Rheumatism: Just a Pre-rheumatoid Stage or Something Else? |
title_full_unstemmed |
Palindromic Rheumatism: Just a Pre-rheumatoid Stage or Something Else? |
title_sort |
palindromic rheumatism: just a pre-rheumatoid stage or something else? |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Medicine |
issn |
2296-858X |
publishDate |
2021-03-01 |
description |
Palindromic rheumatism (PR), a unique clinical entity, has a characteristic clinical presentation with a relapsing/remitting course. It is established that most patients with PR evolve to chronic disease, of which rheumatoid arthritis (RA) is by far the most common. The relationship between PR and RA is unclear, with similarities and differences between the two, and not all patients evolve to RA in the long-term. Therefore, PR is clearly a pre-RA stage for most, but not all, patients. Autoimmunity plays a substantial role in PR, with the same characteristic autoantibody profile observed in RA, although with some differences in the immune response repertoire. Autoinflammation may also be relevant in some cases of PR. Prognostic factors for RA progression are identified but their exact predictive value is not clear. There are several unmet needs in PR, such as the diagnostic criteria and clinical case definition, the pathogenic mechanisms involved in the unusual clinical course, and the evolution to RA, and our understanding of the therapeutic strategy that could best avoid progression to persistent and potentially destructive arthritis. |
topic |
palindromic rheumatism rheumatoid arthritis ACPA pre-RA management |
url |
https://www.frontiersin.org/articles/10.3389/fmed.2021.657983/full |
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