Polymorphisms in Adipokines in Mexican Children with Obesity
The high prevalence of childhood obesity in Mexico is alarming in the health-science field. We propose to investigate the contribution of adipokines and cytokines polymorphisms and common BMI/obesity-associated loci, revealed in genome-wide association studies in Caucasian adult cohorts, with childh...
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Series: | International Journal of Endocrinology |
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doaj-51f060d998f84c47aeda1b794a2309102020-11-25T02:09:25ZengHindawi LimitedInternational Journal of Endocrinology1687-83371687-83452019-01-01201910.1155/2019/47647514764751Polymorphisms in Adipokines in Mexican Children with ObesityAngélica Saraí Jiménez-Osorio0Alma Olivia Aguilar-Lucio1Helios Cárdenas-Hernández2Claudette Musalem-Younes3Jacqueline Solares-Tlapechco4Paula Costa-Urrutia5Oscar Medina-Contreras6Julio Granados7Martha Eunice Rodríguez-Arellano8Laboratorio de Medicina Genómica del Hospital Regional Lic, Adolfo López Mateos, ISSSTE, Av. Universidad 1321, Florida, C.P. 01030, Álvaro Obregón, Mexico City, MexicoServicio de Neonatología del Hospital Regional Lic, Adolfo López Mateos, ISSSTE, Av. Universidad 1321, Florida, C.P. 01030, Álvaro Obregón, Mexico City, MexicoLaboratorio de Medicina Genómica del Hospital Regional Lic, Adolfo López Mateos, ISSSTE, Av. Universidad 1321, Florida, C.P. 01030, Álvaro Obregón, Mexico City, MexicoLaboratorio de Medicina Genómica del Hospital Regional Lic, Adolfo López Mateos, ISSSTE, Av. Universidad 1321, Florida, C.P. 01030, Álvaro Obregón, Mexico City, MexicoLaboratorio de Medicina Genómica del Hospital Regional Lic, Adolfo López Mateos, ISSSTE, Av. Universidad 1321, Florida, C.P. 01030, Álvaro Obregón, Mexico City, MexicoLaboratorio de Medicina Genómica del Hospital Regional Lic, Adolfo López Mateos, ISSSTE, Av. Universidad 1321, Florida, C.P. 01030, Álvaro Obregón, Mexico City, MexicoLaboratorio de Medicina Genómica del Hospital Regional Lic, Adolfo López Mateos, ISSSTE, Av. Universidad 1321, Florida, C.P. 01030, Álvaro Obregón, Mexico City, MexicoLaboratorio de Medicina Genómica del Hospital Regional Lic, Adolfo López Mateos, ISSSTE, Av. Universidad 1321, Florida, C.P. 01030, Álvaro Obregón, Mexico City, MexicoLaboratorio de Medicina Genómica del Hospital Regional Lic, Adolfo López Mateos, ISSSTE, Av. Universidad 1321, Florida, C.P. 01030, Álvaro Obregón, Mexico City, MexicoThe high prevalence of childhood obesity in Mexico is alarming in the health-science field. We propose to investigate the contribution of adipokines and cytokines polymorphisms and common BMI/obesity-associated loci, revealed in genome-wide association studies in Caucasian adult cohorts, with childhood obesity. This study included 773 Mexican-Mestizo children (5-15 years old) in a case-control study. The polymorphisms included were ADIPOQ (rs6444174), TNF-α (rs1800750), IL-1β (rs1143643), IL-6 (rs1524107; rs2069845), NEGR1 (rs34305371), SEC16B-RASAL2 (rs10913469), TMEM18 (rs6548238; rs7561317), GNPDA2 (rs16857402), LEP (rs2167270), MTCH2 (rs10838738), LGR4-LIN7C-BDNF (rs925946), BCDIN3D-FAIM2 (rs7138803), FTO (rs62033400), MC4R (rs11872992), MC4R (rs17782313), and KCTD15 (rs29942). No significant contribution was found with adipokines and cytokines polymorphisms in this study. Only both TMEM18 (rs6548238; rs7561317) polymorphisms were found associated with obesity (OR=0.5, P=0.008) and were in linkage disequilibrium (r2=0.87). The linear regression showed that the rs7561317 polymorphism of TMEM18 is negatively associated with obesity. This report highlights the influence of TMEM18 in Mexican-Mestizo children obesity, while adipokine and cytokine polymorphisms were not associated with it.http://dx.doi.org/10.1155/2019/4764751 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Angélica Saraí Jiménez-Osorio Alma Olivia Aguilar-Lucio Helios Cárdenas-Hernández Claudette Musalem-Younes Jacqueline Solares-Tlapechco Paula Costa-Urrutia Oscar Medina-Contreras Julio Granados Martha Eunice Rodríguez-Arellano |
spellingShingle |
Angélica Saraí Jiménez-Osorio Alma Olivia Aguilar-Lucio Helios Cárdenas-Hernández Claudette Musalem-Younes Jacqueline Solares-Tlapechco Paula Costa-Urrutia Oscar Medina-Contreras Julio Granados Martha Eunice Rodríguez-Arellano Polymorphisms in Adipokines in Mexican Children with Obesity International Journal of Endocrinology |
author_facet |
Angélica Saraí Jiménez-Osorio Alma Olivia Aguilar-Lucio Helios Cárdenas-Hernández Claudette Musalem-Younes Jacqueline Solares-Tlapechco Paula Costa-Urrutia Oscar Medina-Contreras Julio Granados Martha Eunice Rodríguez-Arellano |
author_sort |
Angélica Saraí Jiménez-Osorio |
title |
Polymorphisms in Adipokines in Mexican Children with Obesity |
title_short |
Polymorphisms in Adipokines in Mexican Children with Obesity |
title_full |
Polymorphisms in Adipokines in Mexican Children with Obesity |
title_fullStr |
Polymorphisms in Adipokines in Mexican Children with Obesity |
title_full_unstemmed |
Polymorphisms in Adipokines in Mexican Children with Obesity |
title_sort |
polymorphisms in adipokines in mexican children with obesity |
publisher |
Hindawi Limited |
series |
International Journal of Endocrinology |
issn |
1687-8337 1687-8345 |
publishDate |
2019-01-01 |
description |
The high prevalence of childhood obesity in Mexico is alarming in the health-science field. We propose to investigate the contribution of adipokines and cytokines polymorphisms and common BMI/obesity-associated loci, revealed in genome-wide association studies in Caucasian adult cohorts, with childhood obesity. This study included 773 Mexican-Mestizo children (5-15 years old) in a case-control study. The polymorphisms included were ADIPOQ (rs6444174), TNF-α (rs1800750), IL-1β (rs1143643), IL-6 (rs1524107; rs2069845), NEGR1 (rs34305371), SEC16B-RASAL2 (rs10913469), TMEM18 (rs6548238; rs7561317), GNPDA2 (rs16857402), LEP (rs2167270), MTCH2 (rs10838738), LGR4-LIN7C-BDNF (rs925946), BCDIN3D-FAIM2 (rs7138803), FTO (rs62033400), MC4R (rs11872992), MC4R (rs17782313), and KCTD15 (rs29942). No significant contribution was found with adipokines and cytokines polymorphisms in this study. Only both TMEM18 (rs6548238; rs7561317) polymorphisms were found associated with obesity (OR=0.5, P=0.008) and were in linkage disequilibrium (r2=0.87). The linear regression showed that the rs7561317 polymorphism of TMEM18 is negatively associated with obesity. This report highlights the influence of TMEM18 in Mexican-Mestizo children obesity, while adipokine and cytokine polymorphisms were not associated with it. |
url |
http://dx.doi.org/10.1155/2019/4764751 |
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