Integrating Liquid Biopsy and Radiomics to Monitor Clonal Heterogeneity of EGFR-Positive Non-Small Cell Lung Cancer

Integrating Liquid Biopsy and Radiomics to Monitor Clonal Heterogeneity of EGFR-Positive Non-Small Cell Lung Cancer

BackgroundEGFR-positive Non-small Cell Lung Cancer (NSCLC) is a dynamic entity and tumor progression and resistance to tyrosine kinase inhibitors (TKIs) arise from the accumulation, over time and across different disease sites, of subclonal genetic mutations. For instance, the occurrence of EGFR T79...

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Main Authors: Federico Cucchiara, Marzia Del Re, Simona Valleggi, Chiara Romei, Iacopo Petrini, Maurizio Lucchesi, Stefania Crucitta, Eleonora Rofi, Annalisa De Liperi, Antonio Chella, Antonio Russo, Romano Danesi
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-12-01
Series:Frontiers in Oncology
Subjects:
non-small cell lung cancer
EGFR
liquid biopsy
cell free DNA
radiomics
tyrosine kinase inhibitors
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2020.593831/full

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