The synergistic effect of prebiotics, probiotics and antioxidants on dogs with chronic kidney disease
The use of probiotics, prebiotics and antioxidants could be found beneficial for dogs with chronic kidney disease (CKD). The aim of our case-control study is to evaluate the synergistic effect of a diet integrated with a supplement containing probiotics (Lactobacillus acidophilus), prebiotics (fruct...
Main Authors: | , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Taylor & Francis Group
2021-01-01
|
Series: | Italian Journal of Animal Science |
Subjects: | |
Online Access: | http://dx.doi.org/10.1080/1828051X.2021.1940323 |
id |
doaj-5205e2f6fab943428603f024eeab1738 |
---|---|
record_format |
Article |
spelling |
doaj-5205e2f6fab943428603f024eeab17382021-07-26T14:51:00ZengTaylor & Francis GroupItalian Journal of Animal Science1594-40771828-051X2021-01-012011079108410.1080/1828051X.2021.19403231940323The synergistic effect of prebiotics, probiotics and antioxidants on dogs with chronic kidney diseaseGiorgia Meineri0Vittorio Saettone1Elisabetta Radice2Natascia Bruni3Elisa Martello4Domenico Bergero5Dipartimento di Scienze Veterinarie, Università' degli studi di TorinoDipartimento di Scienze Veterinarie, Università' degli studi di TorinoDipartimento di Scienze Chirurgiche, Università' degli studi di TorinoCandioli Pharma S.r.lDivision of Epidemiology and Public Health, School of Medicine, University of NottinghamDipartimento di Scienze Veterinarie, Università' degli studi di TorinoThe use of probiotics, prebiotics and antioxidants could be found beneficial for dogs with chronic kidney disease (CKD). The aim of our case-control study is to evaluate the synergistic effect of a diet integrated with a supplement containing probiotics (Lactobacillus acidophilus), prebiotics (fructoligosaccharides) and antioxidants (Olea Europaea extract) on the nutritional status and on serum and urinary parameters of dogs with CKD. A total of 30 dogs classified with IRIS CKD stage 3 were enrolled and randomly assigned to a control (CG, n = 15) and a treated (TG n = 15) group. The trial consisted in a 7-days adaptation period, followed by 90 days where animals in the TR group received the supplement, while in the CG group the placebo. No significant changes in body weight and body condition score were recorded. We recorded a significant improvement of the protein plasmatic level and a decrease in blood phosphorus, systolic pressure, BUN, proteinuria and urine protein-to-creatinine ratio throughout the trial in the TG compared to the CG group. Furthermore, the parameters related to inflammation and oxidative stress (C-reactive protein and Reactive Oxygen Metabolite- derived compound, respectively) were lower in the TG than in the CG group throughout the study. Our results showed that the supplement allows to maintain the correct nutritional status and to improve blood and kidney parameters in dogs with advance stage of CKD. This supplement could be considered as a new nutritional approach for treating this condition.HIGHLIGHTS Diet supplemented with prebiotics, probiotics and antioxidants is safe for dogs with CKD. The synergic effect of prebiotics, probiotics and antioxidants included in the supplement under study shows the maintenance of a good nutritional status and the improvement of blood and urinary parameters in dogs with CKD.http://dx.doi.org/10.1080/1828051X.2021.1940323supplementprebioticsprobioticsantioxidantsdogckd |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Giorgia Meineri Vittorio Saettone Elisabetta Radice Natascia Bruni Elisa Martello Domenico Bergero |
spellingShingle |
Giorgia Meineri Vittorio Saettone Elisabetta Radice Natascia Bruni Elisa Martello Domenico Bergero The synergistic effect of prebiotics, probiotics and antioxidants on dogs with chronic kidney disease Italian Journal of Animal Science supplement prebiotics probiotics antioxidants dog ckd |
author_facet |
Giorgia Meineri Vittorio Saettone Elisabetta Radice Natascia Bruni Elisa Martello Domenico Bergero |
author_sort |
Giorgia Meineri |
title |
The synergistic effect of prebiotics, probiotics and antioxidants on dogs with chronic kidney disease |
title_short |
The synergistic effect of prebiotics, probiotics and antioxidants on dogs with chronic kidney disease |
title_full |
The synergistic effect of prebiotics, probiotics and antioxidants on dogs with chronic kidney disease |
title_fullStr |
The synergistic effect of prebiotics, probiotics and antioxidants on dogs with chronic kidney disease |
title_full_unstemmed |
The synergistic effect of prebiotics, probiotics and antioxidants on dogs with chronic kidney disease |
title_sort |
synergistic effect of prebiotics, probiotics and antioxidants on dogs with chronic kidney disease |
publisher |
Taylor & Francis Group |
series |
Italian Journal of Animal Science |
issn |
1594-4077 1828-051X |
publishDate |
2021-01-01 |
description |
The use of probiotics, prebiotics and antioxidants could be found beneficial for dogs with chronic kidney disease (CKD). The aim of our case-control study is to evaluate the synergistic effect of a diet integrated with a supplement containing probiotics (Lactobacillus acidophilus), prebiotics (fructoligosaccharides) and antioxidants (Olea Europaea extract) on the nutritional status and on serum and urinary parameters of dogs with CKD. A total of 30 dogs classified with IRIS CKD stage 3 were enrolled and randomly assigned to a control (CG, n = 15) and a treated (TG n = 15) group. The trial consisted in a 7-days adaptation period, followed by 90 days where animals in the TR group received the supplement, while in the CG group the placebo. No significant changes in body weight and body condition score were recorded. We recorded a significant improvement of the protein plasmatic level and a decrease in blood phosphorus, systolic pressure, BUN, proteinuria and urine protein-to-creatinine ratio throughout the trial in the TG compared to the CG group. Furthermore, the parameters related to inflammation and oxidative stress (C-reactive protein and Reactive Oxygen Metabolite- derived compound, respectively) were lower in the TG than in the CG group throughout the study. Our results showed that the supplement allows to maintain the correct nutritional status and to improve blood and kidney parameters in dogs with advance stage of CKD. This supplement could be considered as a new nutritional approach for treating this condition.HIGHLIGHTS Diet supplemented with prebiotics, probiotics and antioxidants is safe for dogs with CKD. The synergic effect of prebiotics, probiotics and antioxidants included in the supplement under study shows the maintenance of a good nutritional status and the improvement of blood and urinary parameters in dogs with CKD. |
topic |
supplement prebiotics probiotics antioxidants dog ckd |
url |
http://dx.doi.org/10.1080/1828051X.2021.1940323 |
work_keys_str_mv |
AT giorgiameineri thesynergisticeffectofprebioticsprobioticsandantioxidantsondogswithchronickidneydisease AT vittoriosaettone thesynergisticeffectofprebioticsprobioticsandantioxidantsondogswithchronickidneydisease AT elisabettaradice thesynergisticeffectofprebioticsprobioticsandantioxidantsondogswithchronickidneydisease AT natasciabruni thesynergisticeffectofprebioticsprobioticsandantioxidantsondogswithchronickidneydisease AT elisamartello thesynergisticeffectofprebioticsprobioticsandantioxidantsondogswithchronickidneydisease AT domenicobergero thesynergisticeffectofprebioticsprobioticsandantioxidantsondogswithchronickidneydisease AT giorgiameineri synergisticeffectofprebioticsprobioticsandantioxidantsondogswithchronickidneydisease AT vittoriosaettone synergisticeffectofprebioticsprobioticsandantioxidantsondogswithchronickidneydisease AT elisabettaradice synergisticeffectofprebioticsprobioticsandantioxidantsondogswithchronickidneydisease AT natasciabruni synergisticeffectofprebioticsprobioticsandantioxidantsondogswithchronickidneydisease AT elisamartello synergisticeffectofprebioticsprobioticsandantioxidantsondogswithchronickidneydisease AT domenicobergero synergisticeffectofprebioticsprobioticsandantioxidantsondogswithchronickidneydisease |
_version_ |
1721280958117707776 |