Preparation and characterization of Tribulus terrestris-loaded nanoparticles

Background and objectives: Tribulus terrestris is a flowering herb (Zygophyllaceae) with several properties in folk medicine such as diuretic, tonic, aphrodisiac, analgesic, astringent, and stomachic-lithotripter activities. Although, some extracts and phytochemicals represent excellent bio-activity...

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Main Authors: M. Khanavi*, R. Dinarvand, M. Esfandiari-Manesh, N. Bagheri, A. Manayi, M. Mahmood Abadi
Format: Article
Language:English
Published: Iranian Society of Pharmacognosy 2017-11-01
Series:Research Journal of Pharmacognosy
Subjects:
Online Access:http://www.rjpharmacognosy.ir/article_53254_fb1c8df8bd22a543c75a21571190b110.pdf
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spelling doaj-5209cba66c964aeeb80e2f3445a57ebf2020-11-24T23:27:06ZengIranian Society of PharmacognosyResearch Journal of Pharmacognosy2345-44582345-59772017-11-014Supplement515153254Preparation and characterization of Tribulus terrestris-loaded nanoparticlesM. Khanavi*0R. Dinarvand1M. Esfandiari-Manesh2N. Bagheri3A. Manayi4M. Mahmood Abadi5Department of Pharmacognosy, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran. Faculty of Land and Food Systems, University of British Columbia, Vancouver, Canada.Nanotechnology Research Center, Tehran University of Medical Sciences, Tehran, Iran. Department of Pharmaceutics, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.Nanotechnology Research Center, Tehran University of Medical Sciences, Tehran, Iran.Department of Pharmacognosy, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.Medicinal Plants Research Center, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.Medicinal Plants Research Center, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.Background and objectives: Tribulus terrestris is a flowering herb (Zygophyllaceae) with several properties in folk medicine such as diuretic, tonic, aphrodisiac, analgesic, astringent, and stomachic-lithotripter activities. Although, some extracts and phytochemicals represent excellent bio-activity in vitro, less or no in vivo activity is observed due to their improper molecular size. The intend of this research was investigation of the feasibility of encapsulating T. terrestris into [poly (lactic-co-glycolic acid)] PLGA nanoparticles. Methods: Aerial parts of the plant were extracted with aqueous ethanol 85% by percolation apparatus. The nanoparticles of T. terrestris-loaded were prepared using a modified simultaneous double-emulsion solvent evaporation/diffusion method. Elucidations were made on the basis of scanning electron microscopy (SEM) and differential scanning calorimetry (DSC). The content of nanoparticles was analyzed by HPLC with indirect method. Results: The results stated that increasing the portion of plant extract could cause bigger size with no considerable increase in polydispersity index (PDI). The encapsulation efficiency of T. terrestris-loaded nanoparticles was 40.3 to 78.5 and the drug loadings were 0.806 to 6.104, with different ratios of extract. The overall pattern of the release in SDS 1% in dialysis bag in all formulations showed similar and biphasic release kinetic, an initial burst release in the first day followed by constant release over 10 days. Conclusion: An effective approach for the preparation of T. terrestris-loaded PLGA nanoparticles was performed. The controlled release profile showed that these biodegradable PLGA nanoparticles had great potential and should be given particular consideration in further biological researches.http://www.rjpharmacognosy.ir/article_53254_fb1c8df8bd22a543c75a21571190b110.pdfNanoparticlesPLGATribulus terrestris
collection DOAJ
language English
format Article
sources DOAJ
author M. Khanavi*
R. Dinarvand
M. Esfandiari-Manesh
N. Bagheri
A. Manayi
M. Mahmood Abadi
spellingShingle M. Khanavi*
R. Dinarvand
M. Esfandiari-Manesh
N. Bagheri
A. Manayi
M. Mahmood Abadi
Preparation and characterization of Tribulus terrestris-loaded nanoparticles
Research Journal of Pharmacognosy
Nanoparticles
PLGA
Tribulus terrestris
author_facet M. Khanavi*
R. Dinarvand
M. Esfandiari-Manesh
N. Bagheri
A. Manayi
M. Mahmood Abadi
author_sort M. Khanavi*
title Preparation and characterization of Tribulus terrestris-loaded nanoparticles
title_short Preparation and characterization of Tribulus terrestris-loaded nanoparticles
title_full Preparation and characterization of Tribulus terrestris-loaded nanoparticles
title_fullStr Preparation and characterization of Tribulus terrestris-loaded nanoparticles
title_full_unstemmed Preparation and characterization of Tribulus terrestris-loaded nanoparticles
title_sort preparation and characterization of tribulus terrestris-loaded nanoparticles
publisher Iranian Society of Pharmacognosy
series Research Journal of Pharmacognosy
issn 2345-4458
2345-5977
publishDate 2017-11-01
description Background and objectives: Tribulus terrestris is a flowering herb (Zygophyllaceae) with several properties in folk medicine such as diuretic, tonic, aphrodisiac, analgesic, astringent, and stomachic-lithotripter activities. Although, some extracts and phytochemicals represent excellent bio-activity in vitro, less or no in vivo activity is observed due to their improper molecular size. The intend of this research was investigation of the feasibility of encapsulating T. terrestris into [poly (lactic-co-glycolic acid)] PLGA nanoparticles. Methods: Aerial parts of the plant were extracted with aqueous ethanol 85% by percolation apparatus. The nanoparticles of T. terrestris-loaded were prepared using a modified simultaneous double-emulsion solvent evaporation/diffusion method. Elucidations were made on the basis of scanning electron microscopy (SEM) and differential scanning calorimetry (DSC). The content of nanoparticles was analyzed by HPLC with indirect method. Results: The results stated that increasing the portion of plant extract could cause bigger size with no considerable increase in polydispersity index (PDI). The encapsulation efficiency of T. terrestris-loaded nanoparticles was 40.3 to 78.5 and the drug loadings were 0.806 to 6.104, with different ratios of extract. The overall pattern of the release in SDS 1% in dialysis bag in all formulations showed similar and biphasic release kinetic, an initial burst release in the first day followed by constant release over 10 days. Conclusion: An effective approach for the preparation of T. terrestris-loaded PLGA nanoparticles was performed. The controlled release profile showed that these biodegradable PLGA nanoparticles had great potential and should be given particular consideration in further biological researches.
topic Nanoparticles
PLGA
Tribulus terrestris
url http://www.rjpharmacognosy.ir/article_53254_fb1c8df8bd22a543c75a21571190b110.pdf
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