Progression in Vascular Cognitive Impairment: Pathogenesis, Neuroimaging Evaluation, and Treatment

Progression in Vascular Cognitive Impairment: Pathogenesis, Neuroimaging Evaluation, and Treatment

Vascular cognitive impairment (VCI) defines an entire spectrum of neurologic disorders from mild cognitive impairment to dementia caused by cerebral vascular disease. The pathogenesis of VCI includes ischemic factors (e.g., large vessel occlusion and small vessel dysfunction); hemorrhagic factors (e...

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Main Authors: Xin Zhang, Jiabin Su, Chao Gao, Wei Ni, Xinjie Gao, Yuxin Li, Jun Zhang, Yu Lei, Yuxiang Gu
Format: Article
Language:English
Published: SAGE Publishing 2019-01-01
Series:Cell Transplantation
Online Access:https://doi.org/10.1177/0963689718815820
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spelling doaj-52219325234d44eea3cd0e4826f0fc5e2020-11-25T03:28:46ZengSAGE PublishingCell Transplantation0963-68971555-38922019-01-012810.1177/0963689718815820Progression in Vascular Cognitive Impairment: Pathogenesis, Neuroimaging Evaluation, and TreatmentXin Zhang0Jiabin Su1Chao Gao2Wei Ni3Xinjie Gao4Yuxin Li5Jun Zhang6Yu Lei7Yuxiang Gu8 Department of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, China Department of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, China Department of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, China Department of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, China Department of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, China Department of Radiology, Huashan Hospital, Fudan University, Shanghai, China Department of Radiology, Huashan Hospital, Fudan University, Shanghai, China Department of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, China Department of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, ChinaVascular cognitive impairment (VCI) defines an entire spectrum of neurologic disorders from mild cognitive impairment to dementia caused by cerebral vascular disease. The pathogenesis of VCI includes ischemic factors (e.g., large vessel occlusion and small vessel dysfunction); hemorrhagic factors (e.g., intracerebral hemorrhage and subarachnoid hemorrhage); and other factors (combined with Alzheimer’s disease). Clinical evaluations of VCI mainly refer to neuropsychological testing and imaging assessments, including structural and functional neuroimaging, with different advantages. At present, the main treatment for VCI focuses on neurological protection, cerebral blood flow reconstruction, and neurological rehabilitation, such as pharmacological treatment, revascularization, and cognitive training. In this review, we discuss the pathogenesis, neuroimaging evaluation, and treatment of VCI.https://doi.org/10.1177/0963689718815820
collection DOAJ
language English
format Article
sources DOAJ
author Xin Zhang
Jiabin Su
Chao Gao
Wei Ni
Xinjie Gao
Yuxin Li
Jun Zhang
Yu Lei
Yuxiang Gu
spellingShingle Xin Zhang
Jiabin Su
Chao Gao
Wei Ni
Xinjie Gao
Yuxin Li
Jun Zhang
Yu Lei
Yuxiang Gu
Progression in Vascular Cognitive Impairment: Pathogenesis, Neuroimaging Evaluation, and Treatment
Cell Transplantation
author_facet Xin Zhang
Jiabin Su
Chao Gao
Wei Ni
Xinjie Gao
Yuxin Li
Jun Zhang
Yu Lei
Yuxiang Gu
author_sort Xin Zhang
title Progression in Vascular Cognitive Impairment: Pathogenesis, Neuroimaging Evaluation, and Treatment
title_short Progression in Vascular Cognitive Impairment: Pathogenesis, Neuroimaging Evaluation, and Treatment
title_full Progression in Vascular Cognitive Impairment: Pathogenesis, Neuroimaging Evaluation, and Treatment
title_fullStr Progression in Vascular Cognitive Impairment: Pathogenesis, Neuroimaging Evaluation, and Treatment
title_full_unstemmed Progression in Vascular Cognitive Impairment: Pathogenesis, Neuroimaging Evaluation, and Treatment
title_sort progression in vascular cognitive impairment: pathogenesis, neuroimaging evaluation, and treatment
publisher SAGE Publishing
series Cell Transplantation
issn 0963-6897
1555-3892
publishDate 2019-01-01
description Vascular cognitive impairment (VCI) defines an entire spectrum of neurologic disorders from mild cognitive impairment to dementia caused by cerebral vascular disease. The pathogenesis of VCI includes ischemic factors (e.g., large vessel occlusion and small vessel dysfunction); hemorrhagic factors (e.g., intracerebral hemorrhage and subarachnoid hemorrhage); and other factors (combined with Alzheimer’s disease). Clinical evaluations of VCI mainly refer to neuropsychological testing and imaging assessments, including structural and functional neuroimaging, with different advantages. At present, the main treatment for VCI focuses on neurological protection, cerebral blood flow reconstruction, and neurological rehabilitation, such as pharmacological treatment, revascularization, and cognitive training. In this review, we discuss the pathogenesis, neuroimaging evaluation, and treatment of VCI.
url https://doi.org/10.1177/0963689718815820
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