Isolated Thrombocytopenia in Thai Children: Etiology and Result of Bone Marrow Aspiration Study
Background: Isolated thrombocytopenia (IT) refers to an entity of low platelet count without abnormalities of other lineages. Previous studies revealed that the main cause of IT in children without atypical features i.e. hepa- tosplenomegaly or adenopathy was immune thrombocytopenia (ITP), while ac...
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doaj-5229cb33ded64e8889ce7a9f75b2a7172020-11-24T23:16:49ZengMahidol UniversitySiriraj Medical Journal2228-80822016-05-01683127134Isolated Thrombocytopenia in Thai Children: Etiology and Result of Bone Marrow Aspiration StudyKamon Phuakpet0Lalita Musikruk1Kleebsabai Sanpakit2Nassawee Vathana3Department of Pediatrics, Faculty of Medicine Siriraj Hospital, Mahidol UniversityDepartment of Pediatrics, Faculty of Medicine Siriraj Hospital, Mahidol UniversityDepartment of Pediatrics, Faculty of Medicine Siriraj Hospital, Mahidol UniversityDepartment of Pediatrics, Faculty of Medicine Siriraj Hospital, Mahidol UniversityBackground: Isolated thrombocytopenia (IT) refers to an entity of low platelet count without abnormalities of other lineages. Previous studies revealed that the main cause of IT in children without atypical features i.e. hepa- tosplenomegaly or adenopathy was immune thrombocytopenia (ITP), while acute leukemia and aplastic anemia (AA) were other possible causes. However, there was no previous study in Thailand to identify the cause of IT. Objective: To study the bone marrow aspiration (BMA) result in Thai children with IT and to identify the cause of IT in Thai children. Methods: This was a retrospective chart review of children younger than 15 years old with IT who were diag- nosed at Siriraj Hospital during January 1996 to December 2010. All patients had BMA to identify the cause of thrombocytopenia. Demographic data, clinical manifestation, laboratory results including BMA finding, diagnosis and initial treatment were collected and analyzed. Results: One hundred and twenty-nine patients were enrolled to the study. All patients had normal or increased megakaryocytes in their bone marrow, and none of them had more than 5% of blast cells. Most patients (97.7%) were diagnosed as acute ITP while 2.3% were diagnosed with neonatal alloimmune thrombocytopenia. None of the patients had acute leukemia or AA. Conclusion: The BMA result of most patients in this study was compatible to that of ITP, that is none of the patients had acute leukemia or AA. The most common cause of IT in Thai children is acute ITP. This result sug- gested that BMA in children with IT before starting treatment is not necessary.http://www.smj.si.mahidol.ac.th/sirirajmedj/index.php/smj/article/view/18/17Bone marrow aspiration; children; isolated thrombocytopenia; ITP; Thailand |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Kamon Phuakpet Lalita Musikruk Kleebsabai Sanpakit Nassawee Vathana |
spellingShingle |
Kamon Phuakpet Lalita Musikruk Kleebsabai Sanpakit Nassawee Vathana Isolated Thrombocytopenia in Thai Children: Etiology and Result of Bone Marrow Aspiration Study Siriraj Medical Journal Bone marrow aspiration; children; isolated thrombocytopenia; ITP; Thailand |
author_facet |
Kamon Phuakpet Lalita Musikruk Kleebsabai Sanpakit Nassawee Vathana |
author_sort |
Kamon Phuakpet |
title |
Isolated Thrombocytopenia in Thai Children: Etiology and Result of Bone Marrow Aspiration Study |
title_short |
Isolated Thrombocytopenia in Thai Children: Etiology and Result of Bone Marrow Aspiration Study |
title_full |
Isolated Thrombocytopenia in Thai Children: Etiology and Result of Bone Marrow Aspiration Study |
title_fullStr |
Isolated Thrombocytopenia in Thai Children: Etiology and Result of Bone Marrow Aspiration Study |
title_full_unstemmed |
Isolated Thrombocytopenia in Thai Children: Etiology and Result of Bone Marrow Aspiration Study |
title_sort |
isolated thrombocytopenia in thai children: etiology and result of bone marrow aspiration study |
publisher |
Mahidol University |
series |
Siriraj Medical Journal |
issn |
2228-8082 |
publishDate |
2016-05-01 |
description |
Background: Isolated thrombocytopenia (IT) refers to an entity of low platelet count without abnormalities of
other lineages. Previous studies revealed that the main cause of IT in children without atypical features i.e. hepa- tosplenomegaly or adenopathy was immune thrombocytopenia (ITP), while acute leukemia and aplastic anemia
(AA) were other possible causes. However, there was no previous study in Thailand to identify the cause of IT.
Objective: To study the bone marrow aspiration (BMA) result in Thai children with IT and to identify the cause
of IT in Thai children.
Methods: This was a retrospective chart review of children younger than 15 years old with IT who were diag- nosed at Siriraj Hospital during January 1996 to December 2010. All patients had BMA to identify the cause of
thrombocytopenia. Demographic data, clinical manifestation, laboratory results including BMA finding, diagnosis
and initial treatment were collected and analyzed.
Results: One hundred and twenty-nine patients were enrolled to the study. All patients had normal or increased
megakaryocytes in their bone marrow, and none of them had more than 5% of blast cells. Most patients (97.7%)
were diagnosed as acute ITP while 2.3% were diagnosed with neonatal alloimmune thrombocytopenia. None of
the patients had acute leukemia or AA.
Conclusion: The BMA result of most patients in this study was compatible to that of ITP, that is none of the
patients had acute leukemia or AA. The most common cause of IT in Thai children is acute ITP. This result sug- gested that BMA in children with IT before starting treatment is not necessary. |
topic |
Bone marrow aspiration; children; isolated thrombocytopenia; ITP; Thailand |
url |
http://www.smj.si.mahidol.ac.th/sirirajmedj/index.php/smj/article/view/18/17 |
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