The Therapeutic Effects of a Traditional Chinese Medicine Formula Wuzi Yanzong Pill for the Treatment of Oligoasthenozoospermia: A Meta-Analysis of Randomized Controlled Trials
Oligoasthenozoospermia is a crucial factor in male infertility. Wuzi Yanzong (WZYZ) pill is a popular traditional Chinese medicine (TCM) formula which has been used for male infertility treatment for years. However, its effects on semen quality remain controversial. We conducted a preregistered meta...
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doaj-524881088cbb402b99fd776394b0f4da2020-11-25T00:18:23ZengHindawi LimitedEvidence-Based Complementary and Alternative Medicine1741-427X1741-42882018-01-01201810.1155/2018/29680252968025The Therapeutic Effects of a Traditional Chinese Medicine Formula Wuzi Yanzong Pill for the Treatment of Oligoasthenozoospermia: A Meta-Analysis of Randomized Controlled TrialsMing Peng Zhao0Xiao Shi1Grace Wing Shan Kong2Chi Chiu Wang3Justin Che Yuen Wu4Zhi Xiu Lin5Tin Chiu Li6David Yiu Leung Chan7Department of Obstetrics and Gynecology, Prince of Wales Hospital, The Chinese University of Hong Kong, Sha Tin, Hong KongDepartment of Obstetrics and Gynecology, Prince of Wales Hospital, The Chinese University of Hong Kong, Sha Tin, Hong KongDepartment of Obstetrics and Gynecology, Prince of Wales Hospital, The Chinese University of Hong Kong, Sha Tin, Hong KongDepartment of Obstetrics and Gynecology, Prince of Wales Hospital, The Chinese University of Hong Kong, Sha Tin, Hong KongDepartment of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, Sha Tin, Hong KongSchool of Chinese Medicine, The Chinese University of Hong Kong, Sha Tin, Hong KongDepartment of Obstetrics and Gynecology, Prince of Wales Hospital, The Chinese University of Hong Kong, Sha Tin, Hong KongDepartment of Obstetrics and Gynecology, Prince of Wales Hospital, The Chinese University of Hong Kong, Sha Tin, Hong KongOligoasthenozoospermia is a crucial factor in male infertility. Wuzi Yanzong (WZYZ) pill is a popular traditional Chinese medicine (TCM) formula which has been used for male infertility treatment for years. However, its effects on semen quality remain controversial. We conducted a preregistered meta-analysis to assess the effect of WZYZ pill for the therapeutic effects on oligoasthenozoospermia. Five randomized controlled trials including 960 participants were selected from databases of domains in North-East Asian regions, PubMed, Embase, and Cochrane Library. WZYZ pill group yielded a greater mean increment on sperm concentration (5 trials: MD 5.99, 95% CI 2.12–9.85, P=0.002), sperm motility (5 trials: MD 4.57, 95% CI 0.47–8.68, P=0.03), sperm morphology (2 trials: MD −1.93, 95% CI −4.87–1.01, P=0.20), activity of acrosomal enzyme (2 trials: MD 28.27, 95% CI 12.41–44.14, P<0.01), volume of semen (2 trials: MD 0.56, 95% CI 0.21–0.91, P=0.002), and a decrement of sperm DNA fragmentation index (2 trials: MD −3.82, 95% CI −6.45–−1.19, P=0.004). However, qualities of selected studies were generally unsatisfactory, and there was inherent heterogeneity among some of the outcomes. Despite these limitations, the WZYZ pill improved sperm quality by improving several semen parameters and decreasing DNA damage in oligoasthenozoospermia patients.http://dx.doi.org/10.1155/2018/2968025 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Ming Peng Zhao Xiao Shi Grace Wing Shan Kong Chi Chiu Wang Justin Che Yuen Wu Zhi Xiu Lin Tin Chiu Li David Yiu Leung Chan |
spellingShingle |
Ming Peng Zhao Xiao Shi Grace Wing Shan Kong Chi Chiu Wang Justin Che Yuen Wu Zhi Xiu Lin Tin Chiu Li David Yiu Leung Chan The Therapeutic Effects of a Traditional Chinese Medicine Formula Wuzi Yanzong Pill for the Treatment of Oligoasthenozoospermia: A Meta-Analysis of Randomized Controlled Trials Evidence-Based Complementary and Alternative Medicine |
author_facet |
Ming Peng Zhao Xiao Shi Grace Wing Shan Kong Chi Chiu Wang Justin Che Yuen Wu Zhi Xiu Lin Tin Chiu Li David Yiu Leung Chan |
author_sort |
Ming Peng Zhao |
title |
The Therapeutic Effects of a Traditional Chinese Medicine Formula Wuzi Yanzong Pill for the Treatment of Oligoasthenozoospermia: A Meta-Analysis of Randomized Controlled Trials |
title_short |
The Therapeutic Effects of a Traditional Chinese Medicine Formula Wuzi Yanzong Pill for the Treatment of Oligoasthenozoospermia: A Meta-Analysis of Randomized Controlled Trials |
title_full |
The Therapeutic Effects of a Traditional Chinese Medicine Formula Wuzi Yanzong Pill for the Treatment of Oligoasthenozoospermia: A Meta-Analysis of Randomized Controlled Trials |
title_fullStr |
The Therapeutic Effects of a Traditional Chinese Medicine Formula Wuzi Yanzong Pill for the Treatment of Oligoasthenozoospermia: A Meta-Analysis of Randomized Controlled Trials |
title_full_unstemmed |
The Therapeutic Effects of a Traditional Chinese Medicine Formula Wuzi Yanzong Pill for the Treatment of Oligoasthenozoospermia: A Meta-Analysis of Randomized Controlled Trials |
title_sort |
therapeutic effects of a traditional chinese medicine formula wuzi yanzong pill for the treatment of oligoasthenozoospermia: a meta-analysis of randomized controlled trials |
publisher |
Hindawi Limited |
series |
Evidence-Based Complementary and Alternative Medicine |
issn |
1741-427X 1741-4288 |
publishDate |
2018-01-01 |
description |
Oligoasthenozoospermia is a crucial factor in male infertility. Wuzi Yanzong (WZYZ) pill is a popular traditional Chinese medicine (TCM) formula which has been used for male infertility treatment for years. However, its effects on semen quality remain controversial. We conducted a preregistered meta-analysis to assess the effect of WZYZ pill for the therapeutic effects on oligoasthenozoospermia. Five randomized controlled trials including 960 participants were selected from databases of domains in North-East Asian regions, PubMed, Embase, and Cochrane Library. WZYZ pill group yielded a greater mean increment on sperm concentration (5 trials: MD 5.99, 95% CI 2.12–9.85, P=0.002), sperm motility (5 trials: MD 4.57, 95% CI 0.47–8.68, P=0.03), sperm morphology (2 trials: MD −1.93, 95% CI −4.87–1.01, P=0.20), activity of acrosomal enzyme (2 trials: MD 28.27, 95% CI 12.41–44.14, P<0.01), volume of semen (2 trials: MD 0.56, 95% CI 0.21–0.91, P=0.002), and a decrement of sperm DNA fragmentation index (2 trials: MD −3.82, 95% CI −6.45–−1.19, P=0.004). However, qualities of selected studies were generally unsatisfactory, and there was inherent heterogeneity among some of the outcomes. Despite these limitations, the WZYZ pill improved sperm quality by improving several semen parameters and decreasing DNA damage in oligoasthenozoospermia patients. |
url |
http://dx.doi.org/10.1155/2018/2968025 |
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