Coupling Biocompatible Au Nanoclusters and Cellulose Nanofibrils to Prepare the Antibacterial Nanocomposite Films
Cellulose nanofibrils (CNF) is considered as an inexhaustible precursor to produce antibacterial materials, such as antibacterial hydrogel, antibacterial paper, and antibacterial film. However, the poor antimicrobial property of neat CNF required it should be coupled with an antibacterial ingredient...
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doaj-5252aa4dc7574708a725e7c828cd89572020-11-25T03:39:09ZengFrontiers Media S.A.Frontiers in Bioengineering and Biotechnology2296-41852020-08-01810.3389/fbioe.2020.00986548346Coupling Biocompatible Au Nanoclusters and Cellulose Nanofibrils to Prepare the Antibacterial Nanocomposite FilmsPeng Wang0Peng Wang1Baishuang Yin2Huiling Dong3Yibo Zhang4Yangheng Zhang5Rixin Chen6Zukun Yang7Caoxing Huang8Qing Jiang9Qing Jiang10State Key Laboratory of Pharmaceutical Biotechnology, Department of Sports Medicine and Adult Reconstructive Surgery, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing, ChinaJiangsu Engineering Research Center for 3D Bioprinting, Jiangsu, ChinaCollege of Animal Science and Technology, Jilin Agricultural Science and Technology University, Jilin, ChinaCollege of Chemical Engineering, Nanjing Forestry University, Nanjing, ChinaState Key Laboratory of Pharmaceutical Biotechnology, Department of Sports Medicine and Adult Reconstructive Surgery, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing, ChinaDepartment of Periodontology, Nanjing Stomatological Hospital, Medical School of Nanjing University, Nanjing, ChinaDepartment of Periodontology, Nanjing Stomatological Hospital, Medical School of Nanjing University, Nanjing, ChinaJiangsu Key Laboratory of Oral Diseases, Nanjing Medical University, Nanjing, ChinaCollege of Chemical Engineering, Nanjing Forestry University, Nanjing, ChinaState Key Laboratory of Pharmaceutical Biotechnology, Department of Sports Medicine and Adult Reconstructive Surgery, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing, ChinaJiangsu Engineering Research Center for 3D Bioprinting, Jiangsu, ChinaCellulose nanofibrils (CNF) is considered as an inexhaustible precursor to produce antibacterial materials, such as antibacterial hydrogel, antibacterial paper, and antibacterial film. However, the poor antimicrobial property of neat CNF required it should be coupled with an antibacterial ingredient. Herein, biocompatible Au nanoclusters (AuNCs) were synthesized and added into the CNF dispersion to prepare a novel antibacterial film (AuNCs@CNF film). The effects of addition of AuNCs with different amount on the morphology and physicochemical properties of AuNCs@CNF films were characterized using atomic force microscopy (AFM), scanning electron microscopy (SEM), X-ray diffraction (XRD), FTIR (Fourier-transform infrared), light transmittance spectra, and thermogravimetric analysis (TGA). The results showed that AuNCs did not affect the nano-structural features of the CNF film and its basic structures, but could greatly increase the hydrophilicity, the flexibility and the thermal stability of CNF film, which might improve its application in antimicrobial wound-healing dressing. The prepared AuNCs@CNF films demonstrated high antibacterial properties toward Escherichia coli (E. coli) and Streptococcus mutans (S. mutans) both in vitro and in vivo, which can prohibit their growths and promote the healing of bacteria-infected wound, respectively. Thus, the prepared AuNCs@CNF film with great antibacterial properties could be applicable in biomedical field.https://www.frontiersin.org/article/10.3389/fbioe.2020.00986/fullcellulose nanofibrilsAu nanoclustersantimicrobial propertywound-healing dressingmultipurpose films |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Peng Wang Peng Wang Baishuang Yin Huiling Dong Yibo Zhang Yangheng Zhang Rixin Chen Zukun Yang Caoxing Huang Qing Jiang Qing Jiang |
spellingShingle |
Peng Wang Peng Wang Baishuang Yin Huiling Dong Yibo Zhang Yangheng Zhang Rixin Chen Zukun Yang Caoxing Huang Qing Jiang Qing Jiang Coupling Biocompatible Au Nanoclusters and Cellulose Nanofibrils to Prepare the Antibacterial Nanocomposite Films Frontiers in Bioengineering and Biotechnology cellulose nanofibrils Au nanoclusters antimicrobial property wound-healing dressing multipurpose films |
author_facet |
Peng Wang Peng Wang Baishuang Yin Huiling Dong Yibo Zhang Yangheng Zhang Rixin Chen Zukun Yang Caoxing Huang Qing Jiang Qing Jiang |
author_sort |
Peng Wang |
title |
Coupling Biocompatible Au Nanoclusters and Cellulose Nanofibrils to Prepare the Antibacterial Nanocomposite Films |
title_short |
Coupling Biocompatible Au Nanoclusters and Cellulose Nanofibrils to Prepare the Antibacterial Nanocomposite Films |
title_full |
Coupling Biocompatible Au Nanoclusters and Cellulose Nanofibrils to Prepare the Antibacterial Nanocomposite Films |
title_fullStr |
Coupling Biocompatible Au Nanoclusters and Cellulose Nanofibrils to Prepare the Antibacterial Nanocomposite Films |
title_full_unstemmed |
Coupling Biocompatible Au Nanoclusters and Cellulose Nanofibrils to Prepare the Antibacterial Nanocomposite Films |
title_sort |
coupling biocompatible au nanoclusters and cellulose nanofibrils to prepare the antibacterial nanocomposite films |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Bioengineering and Biotechnology |
issn |
2296-4185 |
publishDate |
2020-08-01 |
description |
Cellulose nanofibrils (CNF) is considered as an inexhaustible precursor to produce antibacterial materials, such as antibacterial hydrogel, antibacterial paper, and antibacterial film. However, the poor antimicrobial property of neat CNF required it should be coupled with an antibacterial ingredient. Herein, biocompatible Au nanoclusters (AuNCs) were synthesized and added into the CNF dispersion to prepare a novel antibacterial film (AuNCs@CNF film). The effects of addition of AuNCs with different amount on the morphology and physicochemical properties of AuNCs@CNF films were characterized using atomic force microscopy (AFM), scanning electron microscopy (SEM), X-ray diffraction (XRD), FTIR (Fourier-transform infrared), light transmittance spectra, and thermogravimetric analysis (TGA). The results showed that AuNCs did not affect the nano-structural features of the CNF film and its basic structures, but could greatly increase the hydrophilicity, the flexibility and the thermal stability of CNF film, which might improve its application in antimicrobial wound-healing dressing. The prepared AuNCs@CNF films demonstrated high antibacterial properties toward Escherichia coli (E. coli) and Streptococcus mutans (S. mutans) both in vitro and in vivo, which can prohibit their growths and promote the healing of bacteria-infected wound, respectively. Thus, the prepared AuNCs@CNF film with great antibacterial properties could be applicable in biomedical field. |
topic |
cellulose nanofibrils Au nanoclusters antimicrobial property wound-healing dressing multipurpose films |
url |
https://www.frontiersin.org/article/10.3389/fbioe.2020.00986/full |
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