Long-lasting severe immune dysfunction in Ebola virus disease survivors
Patients who have recovered from Ebola virus can have ongoing health problems. Here, the authors show that 35 Guinean survivors of the last West African Ebola epidemic have a chronic disease with high inflammatory cytokine expression and other markers of immune activation as well as evidence of inte...
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| Format: | Article |
| Language: | English |
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Nature Publishing Group
2020-07-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-020-17489-7 |
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doaj-525bc83b567f4212a1ba8e49aa1000612021-07-25T11:40:37ZengNature Publishing GroupNature Communications2041-17232020-07-0111111110.1038/s41467-020-17489-7Long-lasting severe immune dysfunction in Ebola virus disease survivorsAurélie Wiedemann0Emile Foucat1Hakim Hocini2Cécile Lefebvre3Boris P. Hejblum4Mélany Durand5Miriam Krüger6Alpha Kabinet Keita7Ahidjo Ayouba8Stéphane Mély9José-Carlos Fernandez10Abdoulaye Touré11Slim Fourati12Claire Lévy-Marchal13Hervé Raoul14Eric Delaporte15Lamine Koivogui16Rodolphe Thiébaut17Christine Lacabaratz18Yves Lévy19PostEboGui Study GroupINSERM U955 Team 16, Vaccine Research Institute, Faculté de Médecine, Université Paris-Est CréteilINSERM U955 Team 16, Vaccine Research Institute, Faculté de Médecine, Université Paris-Est CréteilINSERM U955 Team 16, Vaccine Research Institute, Faculté de Médecine, Université Paris-Est CréteilINSERM U955 Team 16, Vaccine Research Institute, Faculté de Médecine, Université Paris-Est CréteilDepartment of Public Health, Inserm Bordeaux Population Health Research Centre, Univ. Bordeaux, Inria SISTM, UMR 1219, Vaccine Research Institute (VRI)Department of Public Health, Inserm Bordeaux Population Health Research Centre, Univ. Bordeaux, Inria SISTM, UMR 1219, Vaccine Research Institute (VRI)Department of Public Health, Inserm Bordeaux Population Health Research Centre, Univ. Bordeaux, Inria SISTM, UMR 1219, Vaccine Research Institute (VRI)TransVIHMI, IRD UMI 233, INSERM U1175, Montpellier UniversityTransVIHMI, IRD UMI 233, INSERM U1175, Montpellier UniversityLaboratoire P4 Inserm-Jean Mérieux, US003 INSERMINSERM U955 Team 16, Vaccine Research Institute, Faculté de Médecine, Université Paris-Est CréteilTransVIHMI, IRD UMI 233, INSERM U1175, Montpellier UniversityAssistance Publique-Hôpitaux de Paris, Groupe Henri-Mondor Albert-Chenevier, Laboratoire de VirologiePôle de Recherche Clinique (PRC), INSERMLaboratoire P4 Inserm-Jean Mérieux, US003 INSERMTransVIHMI, IRD UMI 233, INSERM U1175, Montpellier UniversityInstitut National de Santé Publique (INSP)Department of Public Health, Inserm Bordeaux Population Health Research Centre, Univ. Bordeaux, Inria SISTM, UMR 1219, Vaccine Research Institute (VRI)INSERM U955 Team 16, Vaccine Research Institute, Faculté de Médecine, Université Paris-Est CréteilINSERM U955 Team 16, Vaccine Research Institute, Faculté de Médecine, Université Paris-Est CréteilPatients who have recovered from Ebola virus can have ongoing health problems. Here, the authors show that 35 Guinean survivors of the last West African Ebola epidemic have a chronic disease with high inflammatory cytokine expression and other markers of immune activation as well as evidence of intestinal tissue damage nearly two years after their release from hospital.https://doi.org/10.1038/s41467-020-17489-7 |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Aurélie Wiedemann Emile Foucat Hakim Hocini Cécile Lefebvre Boris P. Hejblum Mélany Durand Miriam Krüger Alpha Kabinet Keita Ahidjo Ayouba Stéphane Mély José-Carlos Fernandez Abdoulaye Touré Slim Fourati Claire Lévy-Marchal Hervé Raoul Eric Delaporte Lamine Koivogui Rodolphe Thiébaut Christine Lacabaratz Yves Lévy PostEboGui Study Group |
| spellingShingle |
Aurélie Wiedemann Emile Foucat Hakim Hocini Cécile Lefebvre Boris P. Hejblum Mélany Durand Miriam Krüger Alpha Kabinet Keita Ahidjo Ayouba Stéphane Mély José-Carlos Fernandez Abdoulaye Touré Slim Fourati Claire Lévy-Marchal Hervé Raoul Eric Delaporte Lamine Koivogui Rodolphe Thiébaut Christine Lacabaratz Yves Lévy PostEboGui Study Group Long-lasting severe immune dysfunction in Ebola virus disease survivors Nature Communications |
| author_facet |
Aurélie Wiedemann Emile Foucat Hakim Hocini Cécile Lefebvre Boris P. Hejblum Mélany Durand Miriam Krüger Alpha Kabinet Keita Ahidjo Ayouba Stéphane Mély José-Carlos Fernandez Abdoulaye Touré Slim Fourati Claire Lévy-Marchal Hervé Raoul Eric Delaporte Lamine Koivogui Rodolphe Thiébaut Christine Lacabaratz Yves Lévy PostEboGui Study Group |
| author_sort |
Aurélie Wiedemann |
| title |
Long-lasting severe immune dysfunction in Ebola virus disease survivors |
| title_short |
Long-lasting severe immune dysfunction in Ebola virus disease survivors |
| title_full |
Long-lasting severe immune dysfunction in Ebola virus disease survivors |
| title_fullStr |
Long-lasting severe immune dysfunction in Ebola virus disease survivors |
| title_full_unstemmed |
Long-lasting severe immune dysfunction in Ebola virus disease survivors |
| title_sort |
long-lasting severe immune dysfunction in ebola virus disease survivors |
| publisher |
Nature Publishing Group |
| series |
Nature Communications |
| issn |
2041-1723 |
| publishDate |
2020-07-01 |
| description |
Patients who have recovered from Ebola virus can have ongoing health problems. Here, the authors show that 35 Guinean survivors of the last West African Ebola epidemic have a chronic disease with high inflammatory cytokine expression and other markers of immune activation as well as evidence of intestinal tissue damage nearly two years after their release from hospital. |
| url |
https://doi.org/10.1038/s41467-020-17489-7 |
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