Comparison of the acute metabolic effect of different infant formulas and human milk in healthy adults: a randomized trial
Abstract Background/Objectives Different infant formulas, varying in protein type and quantity, are available for infants who are not breastfed or are partially breastfed. Postprandial insulinemic and glycemic responses to intact vs partially hydrolyzed protein in infant formula are unclear. To comp...
Main Authors: | , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Nature Publishing Group
2021-04-01
|
Series: | Nutrition & Diabetes |
Online Access: | https://doi.org/10.1038/s41387-021-00154-3 |
id |
doaj-526e489757b44ec5ba4c41897e854ae4 |
---|---|
record_format |
Article |
spelling |
doaj-526e489757b44ec5ba4c41897e854ae42021-04-18T11:03:47ZengNature Publishing GroupNutrition & Diabetes2044-40522021-04-0111111110.1038/s41387-021-00154-3Comparison of the acute metabolic effect of different infant formulas and human milk in healthy adults: a randomized trialYasaman Shahkhalili0Cathriona Monnard1Dominik Grathwohl2Julien Sauser3Maurice Beaumont4Corinne Ammon Zufferey5Katherine Macé6Société des Produits Nestlé S.ASociété des Produits Nestlé S.ASociété des Produits Nestlé S.ASociété des Produits Nestlé S.ASociété des Produits Nestlé S.ASociété des Produits Nestlé S.ASociété des Produits Nestlé S.AAbstract Background/Objectives Different infant formulas, varying in protein type and quantity, are available for infants who are not breastfed or are partially breastfed. Postprandial insulinemic and glycemic responses to intact vs partially hydrolyzed protein in infant formula are unclear. To compare the effect of different forms (partially hydrolyzed vs non-hydrolyzed) and levels of protein in infant formula compared with a human milk reference subgroup on insulin response in adults. Subjects/Methods In a randomized, double-blinded, cross-over study, 35 healthy adults consumed 600 ml of three different infant formulas: Intact protein-based formula (INTACT) (1.87 g protein/100 kcal; whey/casein ratio of 70/30; 63 kcal/100 ml), partially hydrolyzed whey-based formula (PHw) (1.96 g protein/100 kcal; 100% whey; 63 kcal/100 ml), a high-protein partially hydrolyzed whey-based formula (HPPHw) (2.79 g protein/100 kcal; 100%whey; 73 kcal/100 ml) and a subgroup also consumed human milk (HM) (n = 11). Lipid and carbohydrate (lactose) contents were similar (5.1–5.5 and 10.5–11.6 g/100 kcal, respectively). Venous blood samples were taken after overnight fasting and at different intervals for 180 min post-drink for insulin, glucose, blood lipids, GLP-1, glucagon, and C-peptide. Results Twenty-nine subjects (eight consuming HM) adhered to the protocol. INTACT and PHw groups had similar postprandial insulinemia and glycaemia (C max and iAUC) that were not different from those of the HM subgroup. HPPHw resulted in higher postprandial insulin responses (iAUC) relative to all other groups (p < 0.001, p < 0.001, p = 0.002 for the comparison with INTACT, PHw, HM, respectively). HPPHw resulted in a higher glucose response compared to INTACT and PHw (iAUC: p = 0.003, p = 0.001, respectively), but was not different from HM (p = 0.41). Conclusion This study in adults demonstrates similar postprandial insulinemia and glycaemia between INTACT and PHw, close to that of HM, but lower than HPPHw, which had a higher protein content compared to the other test milks. The findings remain to be confirmed in infants. Clinical trial registration This study is registered at clinicaltrials.gov, identifier NCT04332510.https://doi.org/10.1038/s41387-021-00154-3 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Yasaman Shahkhalili Cathriona Monnard Dominik Grathwohl Julien Sauser Maurice Beaumont Corinne Ammon Zufferey Katherine Macé |
spellingShingle |
Yasaman Shahkhalili Cathriona Monnard Dominik Grathwohl Julien Sauser Maurice Beaumont Corinne Ammon Zufferey Katherine Macé Comparison of the acute metabolic effect of different infant formulas and human milk in healthy adults: a randomized trial Nutrition & Diabetes |
author_facet |
Yasaman Shahkhalili Cathriona Monnard Dominik Grathwohl Julien Sauser Maurice Beaumont Corinne Ammon Zufferey Katherine Macé |
author_sort |
Yasaman Shahkhalili |
title |
Comparison of the acute metabolic effect of different infant formulas and human milk in healthy adults: a randomized trial |
title_short |
Comparison of the acute metabolic effect of different infant formulas and human milk in healthy adults: a randomized trial |
title_full |
Comparison of the acute metabolic effect of different infant formulas and human milk in healthy adults: a randomized trial |
title_fullStr |
Comparison of the acute metabolic effect of different infant formulas and human milk in healthy adults: a randomized trial |
title_full_unstemmed |
Comparison of the acute metabolic effect of different infant formulas and human milk in healthy adults: a randomized trial |
title_sort |
comparison of the acute metabolic effect of different infant formulas and human milk in healthy adults: a randomized trial |
publisher |
Nature Publishing Group |
series |
Nutrition & Diabetes |
issn |
2044-4052 |
publishDate |
2021-04-01 |
description |
Abstract Background/Objectives Different infant formulas, varying in protein type and quantity, are available for infants who are not breastfed or are partially breastfed. Postprandial insulinemic and glycemic responses to intact vs partially hydrolyzed protein in infant formula are unclear. To compare the effect of different forms (partially hydrolyzed vs non-hydrolyzed) and levels of protein in infant formula compared with a human milk reference subgroup on insulin response in adults. Subjects/Methods In a randomized, double-blinded, cross-over study, 35 healthy adults consumed 600 ml of three different infant formulas: Intact protein-based formula (INTACT) (1.87 g protein/100 kcal; whey/casein ratio of 70/30; 63 kcal/100 ml), partially hydrolyzed whey-based formula (PHw) (1.96 g protein/100 kcal; 100% whey; 63 kcal/100 ml), a high-protein partially hydrolyzed whey-based formula (HPPHw) (2.79 g protein/100 kcal; 100%whey; 73 kcal/100 ml) and a subgroup also consumed human milk (HM) (n = 11). Lipid and carbohydrate (lactose) contents were similar (5.1–5.5 and 10.5–11.6 g/100 kcal, respectively). Venous blood samples were taken after overnight fasting and at different intervals for 180 min post-drink for insulin, glucose, blood lipids, GLP-1, glucagon, and C-peptide. Results Twenty-nine subjects (eight consuming HM) adhered to the protocol. INTACT and PHw groups had similar postprandial insulinemia and glycaemia (C max and iAUC) that were not different from those of the HM subgroup. HPPHw resulted in higher postprandial insulin responses (iAUC) relative to all other groups (p < 0.001, p < 0.001, p = 0.002 for the comparison with INTACT, PHw, HM, respectively). HPPHw resulted in a higher glucose response compared to INTACT and PHw (iAUC: p = 0.003, p = 0.001, respectively), but was not different from HM (p = 0.41). Conclusion This study in adults demonstrates similar postprandial insulinemia and glycaemia between INTACT and PHw, close to that of HM, but lower than HPPHw, which had a higher protein content compared to the other test milks. The findings remain to be confirmed in infants. Clinical trial registration This study is registered at clinicaltrials.gov, identifier NCT04332510. |
url |
https://doi.org/10.1038/s41387-021-00154-3 |
work_keys_str_mv |
AT yasamanshahkhalili comparisonoftheacutemetaboliceffectofdifferentinfantformulasandhumanmilkinhealthyadultsarandomizedtrial AT cathrionamonnard comparisonoftheacutemetaboliceffectofdifferentinfantformulasandhumanmilkinhealthyadultsarandomizedtrial AT dominikgrathwohl comparisonoftheacutemetaboliceffectofdifferentinfantformulasandhumanmilkinhealthyadultsarandomizedtrial AT juliensauser comparisonoftheacutemetaboliceffectofdifferentinfantformulasandhumanmilkinhealthyadultsarandomizedtrial AT mauricebeaumont comparisonoftheacutemetaboliceffectofdifferentinfantformulasandhumanmilkinhealthyadultsarandomizedtrial AT corinneammonzufferey comparisonoftheacutemetaboliceffectofdifferentinfantformulasandhumanmilkinhealthyadultsarandomizedtrial AT katherinemace comparisonoftheacutemetaboliceffectofdifferentinfantformulasandhumanmilkinhealthyadultsarandomizedtrial |
_version_ |
1721522755291054080 |