Semaphorin 4C Plexin-B2 signaling in peripheral sensory neurons is pronociceptive in a model of inflammatory pain

Semaphorin 4C Plexin-B2 signaling in peripheral sensory neurons is pronociceptive in a model of inflammatory pain

Semaphorins and their receptors are involved in neurodevelopment, but their functions in the adult nervous system are not fully understood. This study finds that semaphorin 4C and its receptor Plexin B are expressed in sensory neurons and are pronociceptive in a mouse model of inflammatory pain.

Bibliographic Details
Main Authors: Eszter Paldy, Manuela Simonetti, Thomas Worzfeld, Kiran Kumar Bali, Lucas Vicuña, Stefan Offermanns, Rohini Kuner
Format: Article
Language:English
Published: Nature Publishing Group 2017-08-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-017-00341-w
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spelling doaj-527b909c401a4c5ebcc7de37bff5164a2021-01-31T12:25:13ZengNature Publishing GroupNature Communications2041-17232017-08-018111510.1038/s41467-017-00341-wSemaphorin 4C Plexin-B2 signaling in peripheral sensory neurons is pronociceptive in a model of inflammatory painEszter Paldy0Manuela Simonetti1Thomas Worzfeld2Kiran Kumar Bali3Lucas Vicuña4Stefan Offermanns5Rohini Kuner6Institute of Pharmacology, Heidelberg UniversityInstitute of Pharmacology, Heidelberg UniversityInstitute of Pharmacology, Marburg UniversityInstitute of Pharmacology, Heidelberg UniversityInstitute of Pharmacology, Heidelberg UniversityDepartment of Pharmacology, Max-Planck-Institute for Heart and Lung ResearchInstitute of Pharmacology, Heidelberg UniversitySemaphorins and their receptors are involved in neurodevelopment, but their functions in the adult nervous system are not fully understood. This study finds that semaphorin 4C and its receptor Plexin B are expressed in sensory neurons and are pronociceptive in a mouse model of inflammatory pain.https://doi.org/10.1038/s41467-017-00341-w
collection DOAJ
language English
format Article
sources DOAJ
author Eszter Paldy
Manuela Simonetti
Thomas Worzfeld
Kiran Kumar Bali
Lucas Vicuña
Stefan Offermanns
Rohini Kuner
spellingShingle Eszter Paldy
Manuela Simonetti
Thomas Worzfeld
Kiran Kumar Bali
Lucas Vicuña
Stefan Offermanns
Rohini Kuner
Semaphorin 4C Plexin-B2 signaling in peripheral sensory neurons is pronociceptive in a model of inflammatory pain
Nature Communications
author_facet Eszter Paldy
Manuela Simonetti
Thomas Worzfeld
Kiran Kumar Bali
Lucas Vicuña
Stefan Offermanns
Rohini Kuner
author_sort Eszter Paldy
title Semaphorin 4C Plexin-B2 signaling in peripheral sensory neurons is pronociceptive in a model of inflammatory pain
title_short Semaphorin 4C Plexin-B2 signaling in peripheral sensory neurons is pronociceptive in a model of inflammatory pain
title_full Semaphorin 4C Plexin-B2 signaling in peripheral sensory neurons is pronociceptive in a model of inflammatory pain
title_fullStr Semaphorin 4C Plexin-B2 signaling in peripheral sensory neurons is pronociceptive in a model of inflammatory pain
title_full_unstemmed Semaphorin 4C Plexin-B2 signaling in peripheral sensory neurons is pronociceptive in a model of inflammatory pain
title_sort semaphorin 4c plexin-b2 signaling in peripheral sensory neurons is pronociceptive in a model of inflammatory pain
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2017-08-01
description Semaphorins and their receptors are involved in neurodevelopment, but their functions in the adult nervous system are not fully understood. This study finds that semaphorin 4C and its receptor Plexin B are expressed in sensory neurons and are pronociceptive in a mouse model of inflammatory pain.
url https://doi.org/10.1038/s41467-017-00341-w
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