Temperature- and pH-sensitive wearable materials for monitoring foot ulcers
Pietro Salvo,1,2 Nicola Calisi,1 Bernardo Melai,1 Valentina Dini,3 Clara Paoletti,1 Tommaso Lomonaco,1 Andrea Pucci,1 Fabio Di Francesco,1 Alberto Piaggesi,4 Marco Romanelli3 1Department of Chemistry and Industrial Chemistry, University of Pisa, 2Institute of Clinical Physiology, National Council o...
Main Authors: | , , , , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Dove Medical Press
2017-01-01
|
Series: | International Journal of Nanomedicine |
Subjects: | |
Online Access: | https://www.dovepress.com/temperature-and-ph-sensitive-wearable-materials-for-monitoring-foot-ul-peer-reviewed-article-IJN |
id |
doaj-527c05244d924182a9813718d9b74e64 |
---|---|
record_format |
Article |
spelling |
doaj-527c05244d924182a9813718d9b74e642020-11-24T22:04:19ZengDove Medical PressInternational Journal of Nanomedicine1178-20132017-01-01Volume 1294995431069Temperature- and pH-sensitive wearable materials for monitoring foot ulcersSalvo PCalisi NMelai BDini VPaoletti CLomonaco TPucci ADi Francesco FPiaggesi ARomanelli MPietro Salvo,1,2 Nicola Calisi,1 Bernardo Melai,1 Valentina Dini,3 Clara Paoletti,1 Tommaso Lomonaco,1 Andrea Pucci,1 Fabio Di Francesco,1 Alberto Piaggesi,4 Marco Romanelli3 1Department of Chemistry and Industrial Chemistry, University of Pisa, 2Institute of Clinical Physiology, National Council of Research, 3Wound Healing Research Unit, Department of Dermatology, University of Pisa, 4Diabetic Foot Section, Department of Medicine, University of Pisa, Pisa, Italy Abstract: Foot ulcers account for 15% of comorbidities associated with diabetes. Presently, no device allows the status of foot ulcers to be continuously monitored when patients are not hospitalized. In this study, we describe a temperature and a pH sensor capable of monitoring diabetic foot and venous leg ulcers developed in the frame of the seventh framework program European Union project SWAN-iCare (smart wearable and autonomous negative pressure device for wound monitoring and therapy). Temperature is measured by exploiting the variations in the electrical resistance of a nanocomposite consisting of multiwalled carbon nanotubes and poly(styrene-b-(ethylene-co-butylene)-b-styrene). The pH sensor used a graphene oxide (GO) layer that changes its electrical potential when pH changes. The temperature sensor has a sensitivity of ~85 Ω/°C in the range 25°C–50°C and a high repeatability (maximum standard deviation of 0.1% over seven repeated measurements). For a GO concentration of 4 mg/mL, the pH sensor has a sensitivity of ~42 mV/pH and high linearity (R2=0.99). Keywords: diabetic foot ulcer, wearable sensors, wound temperature, wound pHhttps://www.dovepress.com/temperature-and-ph-sensitive-wearable-materials-for-monitoring-foot-ul-peer-reviewed-article-IJNdiabetic foot ulcerwearable sensorswound temperaturewound pH. |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Salvo P Calisi N Melai B Dini V Paoletti C Lomonaco T Pucci A Di Francesco F Piaggesi A Romanelli M |
spellingShingle |
Salvo P Calisi N Melai B Dini V Paoletti C Lomonaco T Pucci A Di Francesco F Piaggesi A Romanelli M Temperature- and pH-sensitive wearable materials for monitoring foot ulcers International Journal of Nanomedicine diabetic foot ulcer wearable sensors wound temperature wound pH. |
author_facet |
Salvo P Calisi N Melai B Dini V Paoletti C Lomonaco T Pucci A Di Francesco F Piaggesi A Romanelli M |
author_sort |
Salvo P |
title |
Temperature- and pH-sensitive wearable materials for monitoring foot ulcers |
title_short |
Temperature- and pH-sensitive wearable materials for monitoring foot ulcers |
title_full |
Temperature- and pH-sensitive wearable materials for monitoring foot ulcers |
title_fullStr |
Temperature- and pH-sensitive wearable materials for monitoring foot ulcers |
title_full_unstemmed |
Temperature- and pH-sensitive wearable materials for monitoring foot ulcers |
title_sort |
temperature- and ph-sensitive wearable materials for monitoring foot ulcers |
publisher |
Dove Medical Press |
series |
International Journal of Nanomedicine |
issn |
1178-2013 |
publishDate |
2017-01-01 |
description |
Pietro Salvo,1,2 Nicola Calisi,1 Bernardo Melai,1 Valentina Dini,3 Clara Paoletti,1 Tommaso Lomonaco,1 Andrea Pucci,1 Fabio Di Francesco,1 Alberto Piaggesi,4 Marco Romanelli3 1Department of Chemistry and Industrial Chemistry, University of Pisa, 2Institute of Clinical Physiology, National Council of Research, 3Wound Healing Research Unit, Department of Dermatology, University of Pisa, 4Diabetic Foot Section, Department of Medicine, University of Pisa, Pisa, Italy Abstract: Foot ulcers account for 15% of comorbidities associated with diabetes. Presently, no device allows the status of foot ulcers to be continuously monitored when patients are not hospitalized. In this study, we describe a temperature and a pH sensor capable of monitoring diabetic foot and venous leg ulcers developed in the frame of the seventh framework program European Union project SWAN-iCare (smart wearable and autonomous negative pressure device for wound monitoring and therapy). Temperature is measured by exploiting the variations in the electrical resistance of a nanocomposite consisting of multiwalled carbon nanotubes and poly(styrene-b-(ethylene-co-butylene)-b-styrene). The pH sensor used a graphene oxide (GO) layer that changes its electrical potential when pH changes. The temperature sensor has a sensitivity of ~85 Ω/°C in the range 25°C–50°C and a high repeatability (maximum standard deviation of 0.1% over seven repeated measurements). For a GO concentration of 4 mg/mL, the pH sensor has a sensitivity of ~42 mV/pH and high linearity (R2=0.99). Keywords: diabetic foot ulcer, wearable sensors, wound temperature, wound pH |
topic |
diabetic foot ulcer wearable sensors wound temperature wound pH. |
url |
https://www.dovepress.com/temperature-and-ph-sensitive-wearable-materials-for-monitoring-foot-ul-peer-reviewed-article-IJN |
work_keys_str_mv |
AT salvop temperatureandphsensitivewearablematerialsformonitoringfootulcers AT calisin temperatureandphsensitivewearablematerialsformonitoringfootulcers AT melaib temperatureandphsensitivewearablematerialsformonitoringfootulcers AT diniv temperatureandphsensitivewearablematerialsformonitoringfootulcers AT paolettic temperatureandphsensitivewearablematerialsformonitoringfootulcers AT lomonacot temperatureandphsensitivewearablematerialsformonitoringfootulcers AT puccia temperatureandphsensitivewearablematerialsformonitoringfootulcers AT difrancescof temperatureandphsensitivewearablematerialsformonitoringfootulcers AT piaggesia temperatureandphsensitivewearablematerialsformonitoringfootulcers AT romanellim temperatureandphsensitivewearablematerialsformonitoringfootulcers |
_version_ |
1725829389711572992 |