The Coronavirus SARS-Cov-2: the Complexity of Infection Pathogenesis, the Search of Vaccines and Possible Future Pandemics

• Main Author: E. P. Kharchenko
• Format: Article
• Language: Russian
• Published: Numikom LLC 2020-07-01
• Series: Эпидемиология и вакцинопрофилактика
• Subjects: sars-cov-2; cov-2; s-protein; vaccine; pandemic
• Online Access: https://www.epidemvac.ru/jour/article/view/1025

Relevance. The vaccine against the SARS-Cov-2 coronavirus is considered as the most promising approach to curb (tame) a current pandemic and prevent new one. Among difficulties in vaccine creating is a right choice of immunodominant antigens providing the effectiveness and safety of vaccines. Aim is to show the usefulness of application of the global immune epitope continuum protein relationship concept in the search of vaccines against SARS-Cov-2 and discuss the possible nature of future pandemics. Materials and method. For the computer analysis of peptide (immune epitope) relationship amongst the SARS-Cov-2 structural proteins, human proteins and proteins of other viruses, the search of homologous sequences was made. All protein sequences sequences were used from databases available on the INTERNET. Results. In the SARS-Cov-2 structural proteins, especially in S-protein, there are a large number of peptide sequences homologous to human and viral proteins that may be the cause of autoimmune complications and/or heterologous immunity. Conclusion: The concept of the global immune epitope continuum of protein relationship is of value in the search of immune epitopes for the vaccines against SARS-Cov-2 and allows us to predict the possible risks in vaccines. The coronavirus breaks and pandemics may be more often than the influenza pandemics.