Preliminary study on the galectin molecular diversity in Moroccoan Phlebotomus papatasi sandfly populations
Context: Galactose binding protein (PpGalec) plays an important role in the specificity of Phlebotomus papatasisandfly for Leishmania major. The molecular diversity of this ligand is currently unknown but might havesome influence on the ability of PpGalec to efficiently recognize L. major in natural...
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2011-06-01
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doaj-52a6d6b3520e4017a1eac23ce339a4072020-11-24T23:34:02ZengWolters Kluwer Medknow PublicationsJournal of Vector Borne Diseases0972-90622011-06-014826771Preliminary study on the galectin molecular diversity in Moroccoan Phlebotomus papatasi sandfly populationsS. Guernaoui, D. Garcia, A. Boumezzough, D. Fontenille & D. SerenoContext: Galactose binding protein (PpGalec) plays an important role in the specificity of Phlebotomus papatasisandfly for Leishmania major. The molecular diversity of this ligand is currently unknown but might havesome influence on the ability of PpGalec to efficiently recognize L. major in natural sandfly populations.Objective: To explore the molecular diversity of the P. papatasi Galectin gene (PpGalec) in natural sandflypopulation of Morocco.Results & Conclusions: Sequence variations of PpGalec was analyzed in 31 P. papatasi specimens collectedfrom endemic and non-endemic zoonotic cutaneous leishmaniasis foci of Morocco. Among the 211 amino acidpositions analyzed, 11 are subjected to mutation. Interestingly, we observe that one mutation directly affect anamino acid known to be involved in the substrate recognition by galectin. The repercussion of this polymorphismon the capacity of the galectin to efficiently bind the L. major Lipophosphoglycane (LPG) awaits furtherinvestigations.http://www.mrcindia.org/journal/issues/482067.pdfGalectin binding proteinLeishmania majormolecular diversityPhlebotomus paptas |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
S. Guernaoui, D. Garcia, A. Boumezzough, D. Fontenille & D. Sereno |
spellingShingle |
S. Guernaoui, D. Garcia, A. Boumezzough, D. Fontenille & D. Sereno Preliminary study on the galectin molecular diversity in Moroccoan Phlebotomus papatasi sandfly populations Journal of Vector Borne Diseases Galectin binding protein Leishmania major molecular diversity Phlebotomus paptas |
author_facet |
S. Guernaoui, D. Garcia, A. Boumezzough, D. Fontenille & D. Sereno |
author_sort |
S. Guernaoui, D. Garcia, A. Boumezzough, D. Fontenille & D. Sereno |
title |
Preliminary study on the galectin molecular diversity in Moroccoan Phlebotomus papatasi sandfly populations |
title_short |
Preliminary study on the galectin molecular diversity in Moroccoan Phlebotomus papatasi sandfly populations |
title_full |
Preliminary study on the galectin molecular diversity in Moroccoan Phlebotomus papatasi sandfly populations |
title_fullStr |
Preliminary study on the galectin molecular diversity in Moroccoan Phlebotomus papatasi sandfly populations |
title_full_unstemmed |
Preliminary study on the galectin molecular diversity in Moroccoan Phlebotomus papatasi sandfly populations |
title_sort |
preliminary study on the galectin molecular diversity in moroccoan phlebotomus papatasi sandfly populations |
publisher |
Wolters Kluwer Medknow Publications |
series |
Journal of Vector Borne Diseases |
issn |
0972-9062 |
publishDate |
2011-06-01 |
description |
Context: Galactose binding protein (PpGalec) plays an important role in the specificity of Phlebotomus papatasisandfly for Leishmania major. The molecular diversity of this ligand is currently unknown but might havesome influence on the ability of PpGalec to efficiently recognize L. major in natural sandfly populations.Objective: To explore the molecular diversity of the P. papatasi Galectin gene (PpGalec) in natural sandflypopulation of Morocco.Results & Conclusions: Sequence variations of PpGalec was analyzed in 31 P. papatasi specimens collectedfrom endemic and non-endemic zoonotic cutaneous leishmaniasis foci of Morocco. Among the 211 amino acidpositions analyzed, 11 are subjected to mutation. Interestingly, we observe that one mutation directly affect anamino acid known to be involved in the substrate recognition by galectin. The repercussion of this polymorphismon the capacity of the galectin to efficiently bind the L. major Lipophosphoglycane (LPG) awaits furtherinvestigations. |
topic |
Galectin binding protein Leishmania major molecular diversity Phlebotomus paptas |
url |
http://www.mrcindia.org/journal/issues/482067.pdf |
work_keys_str_mv |
AT sguernaouidgarciaaboumezzoughdfontenilledsereno preliminarystudyonthegalectinmoleculardiversityinmoroccoanphlebotomuspapatasisandflypopulations |
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