Seroprevalence and risk factors of Toxoplasma gondii infection in children with leukemia in Shandong Province, Eastern China: a case—control prospective study
Limited information is available concerning the epidemiology of Toxoplasma gondii infection in children with leukemia in Eastern China. Therefore, a case-control study was conducted to estimate the seroprevalence of toxoplasmosis in this patient group and to identify risk factors and possible routes...
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doaj-52ba0a922ffe4573a6abaee82e1e45892020-11-24T21:43:38ZengPeerJ Inc.PeerJ2167-83592019-03-017e660410.7717/peerj.6604Seroprevalence and risk factors of Toxoplasma gondii infection in children with leukemia in Shandong Province, Eastern China: a case—control prospective studyNa Zhou0Haiyang Fu1Zhongjun Wang2Hailei Shi3Yang Yu4Tingting Qu5Longlong Wang6Xiangyan Zhang7Lin Wang8Department of Pediatrics, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, ChinaDepartment of Pathology, Affiliated Hospital of Qingdao University, Qingdao, ChinaDepartment of Clinical Laboratory, The Affiliated Hospital of Qingdao University, Qingdao, ChinaDepartment of Pathology, Affiliated Hospital of Qingdao University, Qingdao, ChinaDepartment of Clinical Laboratory, The Affiliated Hospital of Qingdao University, Qingdao, ChinaDepartment of Pathology, Affiliated Hospital of Qingdao University, Qingdao, ChinaDepartment of Urinary Surgery, The Affiliated Hospital of Qingdao University, Qingdao, ChinaDepartment of Pathology, Affiliated Hospital of Qingdao University, Qingdao, ChinaDepartment of Pediatrics, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, ChinaLimited information is available concerning the epidemiology of Toxoplasma gondii infection in children with leukemia in Eastern China. Therefore, a case-control study was conducted to estimate the seroprevalence of toxoplasmosis in this patient group and to identify risk factors and possible routes of infection. Serum samples were collected from 339 children with leukemia and 339 age matched health control subjects in Qingdao from September 2014 to March 2018. Enzyme linked immunoassays were used to screen anti- T. gondii IgG and anti- T. gondii IgM antibodies. Forty-eight (14.2%) children with leukemia and 31 (9.1%) control subjects were positive for anti-T. gondii IgG antibodies (P < 0.05), while 13 (3.8%) patients and 14 (4.1%) controls were positive for anti-T. gondii IgM antibodies (P = 0.84). Multivariate analysis showed exposure to soil and a history of blood transfusion were risk factors for T. gondii infection. Compared with IgG, patients with a history of blood transfusion were more likely to present anti- T. gondii IgM (P = 0.003). Moreover, patients with chronic lymphocytic leukemia and acute lymphocytic leukemia had higher T. gondii seroprevalence in comparison to control subjects (P = 0.002 and P = 0.016, respectively). The results indicated that the seroprevalence of T. gondii infection in children with leukemia is higher than that of healthy children in Eastern China. This information may be used to guide future research and clinical management, and further studies are necessary to elucidate the role of T. gondii in children with leukemia.https://peerj.com/articles/6604.pdfToxoplasma gondiiRisk factorsLeukemia childrenSeroprevalence |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Na Zhou Haiyang Fu Zhongjun Wang Hailei Shi Yang Yu Tingting Qu Longlong Wang Xiangyan Zhang Lin Wang |
spellingShingle |
Na Zhou Haiyang Fu Zhongjun Wang Hailei Shi Yang Yu Tingting Qu Longlong Wang Xiangyan Zhang Lin Wang Seroprevalence and risk factors of Toxoplasma gondii infection in children with leukemia in Shandong Province, Eastern China: a case—control prospective study PeerJ Toxoplasma gondii Risk factors Leukemia children Seroprevalence |
author_facet |
Na Zhou Haiyang Fu Zhongjun Wang Hailei Shi Yang Yu Tingting Qu Longlong Wang Xiangyan Zhang Lin Wang |
author_sort |
Na Zhou |
title |
Seroprevalence and risk factors of Toxoplasma gondii infection in children with leukemia in Shandong Province, Eastern China: a case—control prospective study |
title_short |
Seroprevalence and risk factors of Toxoplasma gondii infection in children with leukemia in Shandong Province, Eastern China: a case—control prospective study |
title_full |
Seroprevalence and risk factors of Toxoplasma gondii infection in children with leukemia in Shandong Province, Eastern China: a case—control prospective study |
title_fullStr |
Seroprevalence and risk factors of Toxoplasma gondii infection in children with leukemia in Shandong Province, Eastern China: a case—control prospective study |
title_full_unstemmed |
Seroprevalence and risk factors of Toxoplasma gondii infection in children with leukemia in Shandong Province, Eastern China: a case—control prospective study |
title_sort |
seroprevalence and risk factors of toxoplasma gondii infection in children with leukemia in shandong province, eastern china: a case—control prospective study |
publisher |
PeerJ Inc. |
series |
PeerJ |
issn |
2167-8359 |
publishDate |
2019-03-01 |
description |
Limited information is available concerning the epidemiology of Toxoplasma gondii infection in children with leukemia in Eastern China. Therefore, a case-control study was conducted to estimate the seroprevalence of toxoplasmosis in this patient group and to identify risk factors and possible routes of infection. Serum samples were collected from 339 children with leukemia and 339 age matched health control subjects in Qingdao from September 2014 to March 2018. Enzyme linked immunoassays were used to screen anti- T. gondii IgG and anti- T. gondii IgM antibodies. Forty-eight (14.2%) children with leukemia and 31 (9.1%) control subjects were positive for anti-T. gondii IgG antibodies (P < 0.05), while 13 (3.8%) patients and 14 (4.1%) controls were positive for anti-T. gondii IgM antibodies (P = 0.84). Multivariate analysis showed exposure to soil and a history of blood transfusion were risk factors for T. gondii infection. Compared with IgG, patients with a history of blood transfusion were more likely to present anti- T. gondii IgM (P = 0.003). Moreover, patients with chronic lymphocytic leukemia and acute lymphocytic leukemia had higher T. gondii seroprevalence in comparison to control subjects (P = 0.002 and P = 0.016, respectively). The results indicated that the seroprevalence of T. gondii infection in children with leukemia is higher than that of healthy children in Eastern China. This information may be used to guide future research and clinical management, and further studies are necessary to elucidate the role of T. gondii in children with leukemia. |
topic |
Toxoplasma gondii Risk factors Leukemia children Seroprevalence |
url |
https://peerj.com/articles/6604.pdf |
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