Shotgun proteomics coupled to nanoparticle-based biomarker enrichment reveals a novel panel of extracellular matrix proteins as candidate serum protein biomarkers for early-stage breast cancer detection

Shotgun proteomics coupled to nanoparticle-based biomarker enrichment reveals a novel panel of extracellular matrix proteins as candidate serum protein biomarkers for early-stage breast cancer detection

Abstract Background The lack of specificity and high degree of false positive and false negative rates when using mammographic screening for detecting early-stage breast cancer is a critical issue. Blood-based molecular assays that could be used in adjunct with mammography for increased specificity...

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Bibliographic Details
Main Authors: Claudia Fredolini, Khyatiben V. Pathak, Luisa Paris, Kristina M. Chapple, Kristine A. Tsantilas, Matthew Rosenow, Tony J. Tegeler, Krystine Garcia-Mansfield, Davide Tamburro, Weidong Zhou, Paul Russo, Samuele Massarut, Francesco Facchiano, Claudio Belluco, Ruggero De Maria, Enrico Garaci, Lance Liotta, Emanuel F. Petricoin, Patrick Pirrotte
Format: Article
Language:English
Published: BMC 2020-12-01
Series:Breast Cancer Research
Subjects:
Invasive ductal carcinoma
Mammography
Serum
Protein enrichment
Nanoparticles
Multiple reaction monitoring
Online Access:https://doi.org/10.1186/s13058-020-01373-9

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