Colorectal adenomas contain multiple somatic mutations that do not coincide with synchronous adenocarcinoma specimens.
We have performed a comparative ultrasequencing study of multiple colorectal lesions obtained simultaneously from four patients. Our data show that benign lesions (adenomatous or hyperplastic polyps) contain a high mutational load. Additionally multiple synchronous colorectal lesions show non overla...
Full description
Bibliographic Details
| Main Authors: |
José P Vaqué,
Nerea Martínez,
Ignacio Varela,
Fidel Fernández,
Marta Mayorga,
Sophia Derdak,
Sergi Beltrán,
Thaidy Moreno,
Carmen Almaraz,
Gonzalo De Las Heras,
Mónica Bayés,
Ivo Gut,
Javier Crespo,
Miguel A Piris |
|---|
| Format: | Article
|
|---|
| Language: | English |
|---|
| Published: |
Public Library of Science (PLoS)
2015-01-01
|
|---|
| Series: | PLoS ONE
|
|---|
| Online Access: | http://europepmc.org/articles/PMC4361059?pdf=render
|
|---|
