A review of in vivo and in vitro aspects of alcohol-induced dose dumping

Abstract This review provides a comprehensive list of in vivo and in vitro studies that have investigated alcohol induced dose dumping (AIDD) in modified release dosage forms. Of the numerous classes of drugs commercially available as modified release products, opioids, centrally acting drugs, and d...

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Main Authors:	Susan D’Souza, Stephen Mayock, Alger Salt
Format:	Article
Language:	English
Published:	SpringerOpen 2017-06-01
Series:	AAPS Open
Subjects:	Alcohol induced dose dumping (AIDD) In vitro In vivo Regulatory Opioids Centrally acting drugs
Online Access:	http://link.springer.com/article/10.1186/s41120-017-0014-9

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spelling	doaj-52d6414477bd4595aa7de045c8ea834a2020-11-24T23:23:52ZengSpringerOpenAAPS Open2364-95342017-06-013112010.1186/s41120-017-0014-9A review of in vivo and in vitro aspects of alcohol-induced dose dumpingSusan D’Souza0Stephen Mayock1Alger Salt2Tesaro Inc.Collegium Pharmaceutical Inc.H&A Scientific, Inc.Abstract This review provides a comprehensive list of in vivo and in vitro studies that have investigated alcohol induced dose dumping (AIDD) in modified release dosage forms. Of the numerous classes of drugs commercially available as modified release products, opioids, centrally acting drugs, and drugs with a narrow therapeutic index present high risks from dose dumping, despite being formulated in a manner that releases drug in a tailored or delayed fashion. Awareness of AIDD has led to the withdrawal of a few marketed products by Regulatory Agencies, and black box warnings on others. Since then, significant effort has focused on proving the robustness of a formulation when co-ingested with alcohol. Patient risk is deemed to be low if the formulation and its performance is unimpaired by the presence of 0–40% alcohol under in vivo and in vitro conditions.http://link.springer.com/article/10.1186/s41120-017-0014-9Alcohol induced dose dumping (AIDD)In vitroIn vivoRegulatoryOpioidsCentrally acting drugs
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Susan D’Souza Stephen Mayock Alger Salt
spellingShingle	Susan D’Souza Stephen Mayock Alger Salt A review of in vivo and in vitro aspects of alcohol-induced dose dumping AAPS Open Alcohol induced dose dumping (AIDD) In vitro In vivo Regulatory Opioids Centrally acting drugs
author_facet	Susan D’Souza Stephen Mayock Alger Salt
author_sort	Susan D’Souza
title	A review of in vivo and in vitro aspects of alcohol-induced dose dumping
title_short	A review of in vivo and in vitro aspects of alcohol-induced dose dumping
title_full	A review of in vivo and in vitro aspects of alcohol-induced dose dumping
title_fullStr	A review of in vivo and in vitro aspects of alcohol-induced dose dumping
title_full_unstemmed	A review of in vivo and in vitro aspects of alcohol-induced dose dumping
title_sort	review of in vivo and in vitro aspects of alcohol-induced dose dumping
publisher	SpringerOpen
series	AAPS Open
issn	2364-9534
publishDate	2017-06-01
description	Abstract This review provides a comprehensive list of in vivo and in vitro studies that have investigated alcohol induced dose dumping (AIDD) in modified release dosage forms. Of the numerous classes of drugs commercially available as modified release products, opioids, centrally acting drugs, and drugs with a narrow therapeutic index present high risks from dose dumping, despite being formulated in a manner that releases drug in a tailored or delayed fashion. Awareness of AIDD has led to the withdrawal of a few marketed products by Regulatory Agencies, and black box warnings on others. Since then, significant effort has focused on proving the robustness of a formulation when co-ingested with alcohol. Patient risk is deemed to be low if the formulation and its performance is unimpaired by the presence of 0–40% alcohol under in vivo and in vitro conditions.
topic	Alcohol induced dose dumping (AIDD) In vitro In vivo Regulatory Opioids Centrally acting drugs
url	http://link.springer.com/article/10.1186/s41120-017-0014-9
work_keys_str_mv	AT susandsouza areviewofinvivoandinvitroaspectsofalcoholinduceddosedumping AT stephenmayock areviewofinvivoandinvitroaspectsofalcoholinduceddosedumping AT algersalt areviewofinvivoandinvitroaspectsofalcoholinduceddosedumping AT susandsouza reviewofinvivoandinvitroaspectsofalcoholinduceddosedumping AT stephenmayock reviewofinvivoandinvitroaspectsofalcoholinduceddosedumping AT algersalt reviewofinvivoandinvitroaspectsofalcoholinduceddosedumping
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A review of in vivo and in vitro aspects of alcohol-induced dose dumping

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