Immunohistochemical study in the grading of non-muscle-invasive papillary urothelial carcinoma of the bladder

• Main Authors: V. V. Pugachev, N. A. Gorban, K. N. Safiullin, O. B. Karyakin
• Format: Article
• Language: Russian
• Published: ABV-press 2014-11-01
• Series: Onkourologiâ
• Subjects: papillary urothelial carcinoma; malignancy grade; р53; Ki-67; СК20; С-erbB-2; immunohistochemical examination
• Online Access: http://oncourology.abvpress.ru/index.php/oncur/article/view/378

<p>Tumor grade and pT stage are significant prognostic factors in non-muscle-invasive papillary urothelial bladder carcinoma (BC) therefore  these indicators are of great importance. The purpose of the investigation was to determine whether molecular biological markers (Ki-67 level, p53, CK20, and c-erbB-2 expression) may specify the grade and invasive potential of papillary urothelial<br />BC. The investigators examined the specimens taken after transurethral resection of the bladder from 57 patients (46 men and 11 women) aged 24 to 75 years (mean age 56 ± 1.5 years) with non-muscle-invasive papillary urothelial BC referring to as a moderate and poor prognostic group according to the EORTC scoring system, who had received combined treatment at the Medical Radiology Research Center in 1998 to 2005 (the postoperative follow-up was 2 to 9 years).</p>