The chronotype conjecture in the association between dietary carbohydrate intake and high-sensitivity C-reactive protein (hs-CRP): a cross-sectional study from NHANES 2015 data
Substantial evidence suggests that the timing of macronutrient intake affects cardiovascular health. The present study aims to assess the association between the dietary carbohydrate intake (DCI) and the high-sensitivity C-reactive protein (hs-CRP) combined with the implicati...
Main Authors: | , , , , , |
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Format: | Article |
Language: | English |
Published: |
Brazilian Association of Sleep and Latin American Federation of Sleep Societies
2021-03-01
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Series: | Sleep Science |
Subjects: | |
Online Access: | https://sleepscience.org.br/export-pdf/2904/v14n1a02.pdf |
Summary: | Substantial evidence suggests that the timing of macronutrient intake affects cardiovascular health.
The present study aims to assess the association between the dietary carbohydrate intake (DCI) and
the high-sensitivity C-reactive protein (hs-CRP) combined with the implication of the chronotype.
Thus, we explored the most recently released National Health and Nutrition Examination Survey
(NHANES) data. We analysed data from 5,616 participants of the NHANES in 2015. We selected
participants with available data for the DCI, sleep and wake-up time, and the hs-CRP. Chronotypes
were categorized according to the sleep times. Binary logistic regression analysis was performed
to predict participants with low or high levels of hs-CRP based on the DCI and chronotypes.
Moderation analysis was used to investigate the effect of the chronotypes on the DCI-hs-CRP’s
association. A higher DCI was significantly associated with the higher hs-CRP levels (odds ratio
(OR) = 1.36, 95% confidence interval (CI) = [0.9-1.8]). Moderate evening (ME) chronotypes had
higher risk for high hs-CRP level (OR = 1.15, 95% CI = [1.22-1.23]) compared to the intermediate
and the morning chronotypes. The chronotype significantly moderated the hs-CRP given the DCI
(moderation coefficient, α2=0.05, 95% CI = [0.01-0.08]). The chronotype diminished the hs-CRP
predicted by the DCI. The findings of the study underscore the significance of assessing the
protective effect of individuals’ chronotype concerning cardiovascular health. |
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ISSN: | 1984-0659 1984-0063 |