Biocompatible Polyhydroxyethylaspartamide-based Micelles with Gadolinium for MRI Contrast Agents

Biocompatible Polyhydroxyethylaspartamide-based Micelles with Gadolinium for MRI Contrast Agents

<p>Abstract</p> <p>Biocompatible poly-[<it>N</it>-(2-hydroxyethyl)-<smcaps>d</smcaps>,<smcaps>l</smcaps>-aspartamide]-methoxypoly(ethyleneglycol)-hexadecylamine (PHEA-mPEG-C<sub>16</sub>) conjugated with 1,4,7,10-tetraazacyclododecan-...

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Main Authors: Kim Hyo Jeong, Lee Ha-Young, Seong Hasoo, Shin Byung Cheol, Yuk Soon Hong, Cho Sun Hang, Kwak Byung-Kook, Jeong Sang Young, Hwang Sung-Joo
Format: Article
Language:English
Published: SpringerOpen 2010-01-01
Series:Nanoscale Research Letters
Subjects:
MRI contrast agent
PHEA derivatives
Micelles
Nanoparticles
Gd contrast agent
Online Access:http://dx.doi.org/10.1007/s11671-010-9734-7
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spelling doaj-52f02d331b92472f811278b98ff9c4392020-11-24T23:01:48ZengSpringerOpenNanoscale Research Letters1931-75731556-276X2010-01-0151219701976Biocompatible Polyhydroxyethylaspartamide-based Micelles with Gadolinium for MRI Contrast AgentsKim Hyo JeongLee Ha-YoungSeong HasooShin Byung CheolYuk Soon HongCho Sun HangKwak Byung-KookJeong Sang YoungHwang Sung-Joo<p>Abstract</p> <p>Biocompatible poly-[<it>N</it>-(2-hydroxyethyl)-<smcaps>d</smcaps>,<smcaps>l</smcaps>-aspartamide]-methoxypoly(ethyleneglycol)-hexadecylamine (PHEA-mPEG-C<sub>16</sub>) conjugated with 1,4,7,10-tetraazacyclododecan-1,4,7,10-tetraacetic acid-gadolinium (DOTA-Gd) via ethylenediamine (ED) was synthesized as a magnetic resonance imaging (MRI) contrast agent. Amphiphilic PHEA-mPEG-C<sub>16</sub>-ED-DOTA-Gd forms micelle in aqueous solution. All the synthesized materials were characterized by proton nuclear magnetic resonance (<sup>1</sup>H NMR). Micelle size and shape were examined by dynamic light scattering (DLS) and atomic force microscopy (AFM). Micelles with PHEA-mPEG-C<sub>16</sub>-ED-DOTA-Gd showed higher relaxivities than the commercially available gadolinium contrast agent. Moreover, the signal intensity of a rabbit liver was effectively increased after intravenous injection of PHEA-mPEG-C<sub>16</sub>-ED-DOTA-Gd.</p> http://dx.doi.org/10.1007/s11671-010-9734-7MRI contrast agentPHEA derivativesMicellesNanoparticlesGd contrast agent
collection DOAJ
language English
format Article
sources DOAJ
author Kim Hyo Jeong
Lee Ha-Young
Seong Hasoo
Shin Byung Cheol
Yuk Soon Hong
Cho Sun Hang
Kwak Byung-Kook
Jeong Sang Young
Hwang Sung-Joo
spellingShingle Kim Hyo Jeong
Lee Ha-Young
Seong Hasoo
Shin Byung Cheol
Yuk Soon Hong
Cho Sun Hang
Kwak Byung-Kook
Jeong Sang Young
Hwang Sung-Joo
Biocompatible Polyhydroxyethylaspartamide-based Micelles with Gadolinium for MRI Contrast Agents
Nanoscale Research Letters
MRI contrast agent
PHEA derivatives
Micelles
Nanoparticles
Gd contrast agent
author_facet Kim Hyo Jeong
Lee Ha-Young
Seong Hasoo
Shin Byung Cheol
Yuk Soon Hong
Cho Sun Hang
Kwak Byung-Kook
Jeong Sang Young
Hwang Sung-Joo
author_sort Kim Hyo Jeong
title Biocompatible Polyhydroxyethylaspartamide-based Micelles with Gadolinium for MRI Contrast Agents
title_short Biocompatible Polyhydroxyethylaspartamide-based Micelles with Gadolinium for MRI Contrast Agents
title_full Biocompatible Polyhydroxyethylaspartamide-based Micelles with Gadolinium for MRI Contrast Agents
title_fullStr Biocompatible Polyhydroxyethylaspartamide-based Micelles with Gadolinium for MRI Contrast Agents
title_full_unstemmed Biocompatible Polyhydroxyethylaspartamide-based Micelles with Gadolinium for MRI Contrast Agents
title_sort biocompatible polyhydroxyethylaspartamide-based micelles with gadolinium for mri contrast agents
publisher SpringerOpen
series Nanoscale Research Letters
issn 1931-7573
1556-276X
publishDate 2010-01-01
description <p>Abstract</p> <p>Biocompatible poly-[<it>N</it>-(2-hydroxyethyl)-<smcaps>d</smcaps>,<smcaps>l</smcaps>-aspartamide]-methoxypoly(ethyleneglycol)-hexadecylamine (PHEA-mPEG-C<sub>16</sub>) conjugated with 1,4,7,10-tetraazacyclododecan-1,4,7,10-tetraacetic acid-gadolinium (DOTA-Gd) via ethylenediamine (ED) was synthesized as a magnetic resonance imaging (MRI) contrast agent. Amphiphilic PHEA-mPEG-C<sub>16</sub>-ED-DOTA-Gd forms micelle in aqueous solution. All the synthesized materials were characterized by proton nuclear magnetic resonance (<sup>1</sup>H NMR). Micelle size and shape were examined by dynamic light scattering (DLS) and atomic force microscopy (AFM). Micelles with PHEA-mPEG-C<sub>16</sub>-ED-DOTA-Gd showed higher relaxivities than the commercially available gadolinium contrast agent. Moreover, the signal intensity of a rabbit liver was effectively increased after intravenous injection of PHEA-mPEG-C<sub>16</sub>-ED-DOTA-Gd.</p>
topic MRI contrast agent
PHEA derivatives
Micelles
Nanoparticles
Gd contrast agent
url http://dx.doi.org/10.1007/s11671-010-9734-7
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