Predictor of poor coronary collaterals in chronic kidney disease population with significant coronary artery disease
<p>Abstract</p> <p>Background</p> <p>Coronary collateral circulation plays an important role to protect myocardium from ischemia, preserve myocardial contractility and reduce cardiovascular events. Chronic kidney disease (CKD) is associated with poor coronary collateral...
Main Authors: | , , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
BMC
2012-08-01
|
Series: | BMC Nephrology |
Subjects: | |
Online Access: | http://www.biomedcentral.com/1471-2369/13/98 |
id |
doaj-52f9e95c6f01483ea63a55f3097f17ed |
---|---|
record_format |
Article |
spelling |
doaj-52f9e95c6f01483ea63a55f3097f17ed2020-11-25T00:38:53ZengBMCBMC Nephrology1471-23692012-08-011319810.1186/1471-2369-13-98Predictor of poor coronary collaterals in chronic kidney disease population with significant coronary artery diseaseHsu Po-ChaoJuo Suh-HangSu Ho-MingChen Szu-ChiaTsai Wei-chungLai Wen-TerSheu Sheng-HsiungLin Tsung-Hsien<p>Abstract</p> <p>Background</p> <p>Coronary collateral circulation plays an important role to protect myocardium from ischemia, preserve myocardial contractility and reduce cardiovascular events. Chronic kidney disease (CKD) is associated with poor coronary collateral development and cardiovascular outcome. However, limited research investigates the predictors for collateral development in the CKD population.</p> <p>Methods</p> <p>We evaluated 970 consecutive patients undergoing coronary angiography and 202 patients with CKD, defined as a glomerular filtration rate less than 60 ml/min/1.73 m<sup>2</sup>, were finally analyzed. The collateral scoring system developed by Rentrop was used to classify patients into poor (grades 0 and 1) or good (grades 2 and 3) collateral group.</p> <p>Results</p> <p>The patients with poor collateral (n = 122) had a higher incidence of hypertension (82% vs 63.8%, p = 0.005), fewer diseased vessels numbers (2.1 ± 0.9 vs 2.6 ± 0.6, p < 0.001) and a trend to be diabetic (56.6% vs. 43.8%, p = 0.085) or female sex (37.7% vs. 25.0%, p = 0.067). Multivariate analysis showed hypertension (odd ratio (OR) 2.672, p = 0.006), diabetes (OR 1.956, p = 0.039) and diseased vessels numbers (OR 0.402, p < 0.001) were significant predictors of poor coronary collaterals development. Furthermore, hypertension and diabetes have a negative synergistic effect on collateral development (p = 0.004 for interaction).</p> <p>Conclusions</p> <p>In the CKD population hypertension and diabetes might negatively influence the coronary collaterals development.</p> http://www.biomedcentral.com/1471-2369/13/98Chronic kidney diseaseCoronary artery diseaseCoronary collateral circulation, Hypertension, Diabetes |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Hsu Po-Chao Juo Suh-Hang Su Ho-Ming Chen Szu-Chia Tsai Wei-chung Lai Wen-Ter Sheu Sheng-Hsiung Lin Tsung-Hsien |
spellingShingle |
Hsu Po-Chao Juo Suh-Hang Su Ho-Ming Chen Szu-Chia Tsai Wei-chung Lai Wen-Ter Sheu Sheng-Hsiung Lin Tsung-Hsien Predictor of poor coronary collaterals in chronic kidney disease population with significant coronary artery disease BMC Nephrology Chronic kidney disease Coronary artery disease Coronary collateral circulation, Hypertension, Diabetes |
author_facet |
Hsu Po-Chao Juo Suh-Hang Su Ho-Ming Chen Szu-Chia Tsai Wei-chung Lai Wen-Ter Sheu Sheng-Hsiung Lin Tsung-Hsien |
author_sort |
Hsu Po-Chao |
title |
Predictor of poor coronary collaterals in chronic kidney disease population with significant coronary artery disease |
title_short |
Predictor of poor coronary collaterals in chronic kidney disease population with significant coronary artery disease |
title_full |
Predictor of poor coronary collaterals in chronic kidney disease population with significant coronary artery disease |
title_fullStr |
Predictor of poor coronary collaterals in chronic kidney disease population with significant coronary artery disease |
title_full_unstemmed |
Predictor of poor coronary collaterals in chronic kidney disease population with significant coronary artery disease |
title_sort |
predictor of poor coronary collaterals in chronic kidney disease population with significant coronary artery disease |
publisher |
BMC |
series |
BMC Nephrology |
issn |
1471-2369 |
publishDate |
2012-08-01 |
description |
<p>Abstract</p> <p>Background</p> <p>Coronary collateral circulation plays an important role to protect myocardium from ischemia, preserve myocardial contractility and reduce cardiovascular events. Chronic kidney disease (CKD) is associated with poor coronary collateral development and cardiovascular outcome. However, limited research investigates the predictors for collateral development in the CKD population.</p> <p>Methods</p> <p>We evaluated 970 consecutive patients undergoing coronary angiography and 202 patients with CKD, defined as a glomerular filtration rate less than 60 ml/min/1.73 m<sup>2</sup>, were finally analyzed. The collateral scoring system developed by Rentrop was used to classify patients into poor (grades 0 and 1) or good (grades 2 and 3) collateral group.</p> <p>Results</p> <p>The patients with poor collateral (n = 122) had a higher incidence of hypertension (82% vs 63.8%, p = 0.005), fewer diseased vessels numbers (2.1 ± 0.9 vs 2.6 ± 0.6, p < 0.001) and a trend to be diabetic (56.6% vs. 43.8%, p = 0.085) or female sex (37.7% vs. 25.0%, p = 0.067). Multivariate analysis showed hypertension (odd ratio (OR) 2.672, p = 0.006), diabetes (OR 1.956, p = 0.039) and diseased vessels numbers (OR 0.402, p < 0.001) were significant predictors of poor coronary collaterals development. Furthermore, hypertension and diabetes have a negative synergistic effect on collateral development (p = 0.004 for interaction).</p> <p>Conclusions</p> <p>In the CKD population hypertension and diabetes might negatively influence the coronary collaterals development.</p> |
topic |
Chronic kidney disease Coronary artery disease Coronary collateral circulation, Hypertension, Diabetes |
url |
http://www.biomedcentral.com/1471-2369/13/98 |
work_keys_str_mv |
AT hsupochao predictorofpoorcoronarycollateralsinchronickidneydiseasepopulationwithsignificantcoronaryarterydisease AT juosuhhang predictorofpoorcoronarycollateralsinchronickidneydiseasepopulationwithsignificantcoronaryarterydisease AT suhoming predictorofpoorcoronarycollateralsinchronickidneydiseasepopulationwithsignificantcoronaryarterydisease AT chenszuchia predictorofpoorcoronarycollateralsinchronickidneydiseasepopulationwithsignificantcoronaryarterydisease AT tsaiweichung predictorofpoorcoronarycollateralsinchronickidneydiseasepopulationwithsignificantcoronaryarterydisease AT laiwenter predictorofpoorcoronarycollateralsinchronickidneydiseasepopulationwithsignificantcoronaryarterydisease AT sheushenghsiung predictorofpoorcoronarycollateralsinchronickidneydiseasepopulationwithsignificantcoronaryarterydisease AT lintsunghsien predictorofpoorcoronarycollateralsinchronickidneydiseasepopulationwithsignificantcoronaryarterydisease |
_version_ |
1725296034700066816 |