Full-length genomic sequence of hepatitis B virus genotype C2 isolated from a native Brazilian patient

• Main Authors: Mónica Viviana Alvarado-Mora, Rúbia Anita Ferraz Santana, Roberta Sitnik, Paulo Roberto Abrão Ferreira, Cristovão Luís Pitangueira Mangueira, Flair José Carrilho, João Renato Rebello Pinho
• Format: Article
• Language: English
• Published: Instituto Oswaldo Cruz, Ministério da Saúde 2011-06-01
• Series: Memórias do Instituto Oswaldo Cruz.
• Subjects: hepatitis B virus; genotype C2; China; Bayesian analyses; complete genome; Brazilian patient
• Online Access: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762011000400017&lng=en&tlng=en
• ISSN: 1678-8060

The hepatitis B virus (HBV) is among the leading causes of chronic hepatitis, cirrhosis and hepatocellular carcinoma. In Brazil, genotype A is the most frequent, followed by genotypes D and F. Genotypes B and C are found in Brazil exclusively among Asian patients and their descendants. The aim of this study was to sequence the entire HBV genome of a Caucasian patient infected with HBV/C2 and to infer the origin of the virus based on sequencing analysis. The sequence of this Brazilian isolate was grouped with four other sequences described in China. The sequence of this patient is the first complete genome of HBV/C2 reported in Brazil.