Recent Advances in the Vaccine Development Against Middle East Respiratory Syndrome-Coronavirus
Middle East respiratory syndrome (MERS) is a deadly viral respiratory disease caused by MERS-coronavirus (MERS-CoV) infection. To date, there is no specific treatment proven effective against this viral disease. In addition, no vaccine has been licensed to prevent MERS-CoV infection thus far. Theref...
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doaj-530f531eebd3409896cf49fde0d4e6a82020-11-25T00:37:47ZengFrontiers Media S.A.Frontiers in Microbiology1664-302X2019-08-011010.3389/fmicb.2019.01781471306Recent Advances in the Vaccine Development Against Middle East Respiratory Syndrome-CoronavirusChean Yeah Yong0Chean Yeah Yong1Hui Kian Ong2Swee Keong Yeap3Kok Lian Ho4Wen Siang Tan5Wen Siang Tan6Department of Microbiology, Faculty of Biotechnology and Biomolecular Sciences, Universiti Putra Malaysia, Serdang, MalaysiaLaboratory of Vaccines and Immunotherapeutics, Institute of Bioscience, Universiti Putra Malaysia, Serdang, MalaysiaDepartment of Pathology, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Serdang, MalaysiaChina ASEAN College of Marine Sciences, Xiamen University Malaysia, Sepang, MalaysiaDepartment of Pathology, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Serdang, MalaysiaDepartment of Microbiology, Faculty of Biotechnology and Biomolecular Sciences, Universiti Putra Malaysia, Serdang, MalaysiaLaboratory of Vaccines and Immunotherapeutics, Institute of Bioscience, Universiti Putra Malaysia, Serdang, MalaysiaMiddle East respiratory syndrome (MERS) is a deadly viral respiratory disease caused by MERS-coronavirus (MERS-CoV) infection. To date, there is no specific treatment proven effective against this viral disease. In addition, no vaccine has been licensed to prevent MERS-CoV infection thus far. Therefore, our current review focuses on the most recent studies in search of an effective MERS vaccine. Overall, vaccine candidates against MERS-CoV are mainly based upon the viral spike (S) protein, due to its vital role in the viral infectivity, although several studies focused on other viral proteins such as the nucleocapsid (N) protein, envelope (E) protein, and non-structural protein 16 (NSP16) have also been reported. In general, the potential vaccine candidates can be classified into six types: viral vector-based vaccine, DNA vaccine, subunit vaccine, nanoparticle-based vaccine, inactivated-whole virus vaccine and live-attenuated vaccine, which are discussed in detail. Besides, the immune responses and potential antibody dependent enhancement of MERS-CoV infection are extensively reviewed. In addition, animal models used to study MERS-CoV and evaluate the vaccine candidates are discussed intensively.https://www.frontiersin.org/article/10.3389/fmicb.2019.01781/fullMiddle East respiratory syndromecoronavirusanimal modelvaccineantibody dependent enhancement |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Chean Yeah Yong Chean Yeah Yong Hui Kian Ong Swee Keong Yeap Kok Lian Ho Wen Siang Tan Wen Siang Tan |
spellingShingle |
Chean Yeah Yong Chean Yeah Yong Hui Kian Ong Swee Keong Yeap Kok Lian Ho Wen Siang Tan Wen Siang Tan Recent Advances in the Vaccine Development Against Middle East Respiratory Syndrome-Coronavirus Frontiers in Microbiology Middle East respiratory syndrome coronavirus animal model vaccine antibody dependent enhancement |
author_facet |
Chean Yeah Yong Chean Yeah Yong Hui Kian Ong Swee Keong Yeap Kok Lian Ho Wen Siang Tan Wen Siang Tan |
author_sort |
Chean Yeah Yong |
title |
Recent Advances in the Vaccine Development Against Middle East Respiratory Syndrome-Coronavirus |
title_short |
Recent Advances in the Vaccine Development Against Middle East Respiratory Syndrome-Coronavirus |
title_full |
Recent Advances in the Vaccine Development Against Middle East Respiratory Syndrome-Coronavirus |
title_fullStr |
Recent Advances in the Vaccine Development Against Middle East Respiratory Syndrome-Coronavirus |
title_full_unstemmed |
Recent Advances in the Vaccine Development Against Middle East Respiratory Syndrome-Coronavirus |
title_sort |
recent advances in the vaccine development against middle east respiratory syndrome-coronavirus |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Microbiology |
issn |
1664-302X |
publishDate |
2019-08-01 |
description |
Middle East respiratory syndrome (MERS) is a deadly viral respiratory disease caused by MERS-coronavirus (MERS-CoV) infection. To date, there is no specific treatment proven effective against this viral disease. In addition, no vaccine has been licensed to prevent MERS-CoV infection thus far. Therefore, our current review focuses on the most recent studies in search of an effective MERS vaccine. Overall, vaccine candidates against MERS-CoV are mainly based upon the viral spike (S) protein, due to its vital role in the viral infectivity, although several studies focused on other viral proteins such as the nucleocapsid (N) protein, envelope (E) protein, and non-structural protein 16 (NSP16) have also been reported. In general, the potential vaccine candidates can be classified into six types: viral vector-based vaccine, DNA vaccine, subunit vaccine, nanoparticle-based vaccine, inactivated-whole virus vaccine and live-attenuated vaccine, which are discussed in detail. Besides, the immune responses and potential antibody dependent enhancement of MERS-CoV infection are extensively reviewed. In addition, animal models used to study MERS-CoV and evaluate the vaccine candidates are discussed intensively. |
topic |
Middle East respiratory syndrome coronavirus animal model vaccine antibody dependent enhancement |
url |
https://www.frontiersin.org/article/10.3389/fmicb.2019.01781/full |
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