The effect of vitamin D supplementation on bone formation around titanium implants in diabetic rats
Background: Diabetes has become the next most widespread disease after cancer. Recent studies have found that diabetes and moderate to severe vitamin D deficiency are associated with reduced bone mineral content; therefore administration of vitamin D may correct these conditions. The purpose of this...
Main Authors: | , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Wolters Kluwer Medknow Publications
2012-01-01
|
Series: | Dental Research Journal |
Subjects: | |
Online Access: | http://www.drjjournal.net/article.asp?issn=1735-3327;year=2012;volume=9;issue=5;spage=582;epage=587;aulast=Akhavan |
id |
doaj-5312ec1a06bb45ac8e14d18abb6c0e9f |
---|---|
record_format |
Article |
spelling |
doaj-5312ec1a06bb45ac8e14d18abb6c0e9f2020-11-25T02:16:40ZengWolters Kluwer Medknow PublicationsDental Research Journal1735-33272008-02552012-01-019558258710.4103/1735-3327.104877The effect of vitamin D supplementation on bone formation around titanium implants in diabetic ratsAli AkhavanZahra NorooziAmir Abbas ShafieiAbbas HaghighatGholam Reza JahanshahiSayed Behrouz MousaviBackground: Diabetes has become the next most widespread disease after cancer. Recent studies have found that diabetes and moderate to severe vitamin D deficiency are associated with reduced bone mineral content; therefore administration of vitamin D may correct these conditions. The purpose of this research is to compare the effect of vitamin D administration on bone to implant contact in diabetic rats with control group. Materials and Methods: In this randomized placebo-controlled trial, 48 Wistar rats were rendered diabetic (130≤ blood sugar ≤200 mg/dl) by IV injection of 35 mg/kg Alloxan. Implants were inserted in tibial bone; Then rats were divided into study and control groups and received oral vitamin D3 (160 IU) or placebo respectively for one week. Bone to implant contact value was measured under light microscope at 3 and 6 weeks. Results: Analysis of data indicated that vitamin D had no significant effect on bone to implant contact (BIC). At 3 weeks, the control group (n = 5) reported BIC level at 44 ± 19 and study group (n = 7) at 57 ± 20. At 6 weeks, the control group (n = 5) reported BIC level at 70 ± 29, and study group (n = 10) at 65 ± 22. Twenty one samples were missed because of death or incorrect lab processes. Conclusion: It seems that vitamin D supplement has no significant effect on BIC in 130 mg/dL ≤ blood sugar ≤200 mg/dL (P = 0.703) andwas also not time dependent (P = 0.074).http://www.drjjournal.net/article.asp?issn=1735-3327;year=2012;volume=9;issue=5;spage=582;epage=587;aulast=AkhavanAloxanbone-implant contacttype 2 diabetesvitamin D |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Ali Akhavan Zahra Noroozi Amir Abbas Shafiei Abbas Haghighat Gholam Reza Jahanshahi Sayed Behrouz Mousavi |
spellingShingle |
Ali Akhavan Zahra Noroozi Amir Abbas Shafiei Abbas Haghighat Gholam Reza Jahanshahi Sayed Behrouz Mousavi The effect of vitamin D supplementation on bone formation around titanium implants in diabetic rats Dental Research Journal Aloxan bone-implant contact type 2 diabetes vitamin D |
author_facet |
Ali Akhavan Zahra Noroozi Amir Abbas Shafiei Abbas Haghighat Gholam Reza Jahanshahi Sayed Behrouz Mousavi |
author_sort |
Ali Akhavan |
title |
The effect of vitamin D supplementation on bone formation around titanium implants in diabetic rats |
title_short |
The effect of vitamin D supplementation on bone formation around titanium implants in diabetic rats |
title_full |
The effect of vitamin D supplementation on bone formation around titanium implants in diabetic rats |
title_fullStr |
The effect of vitamin D supplementation on bone formation around titanium implants in diabetic rats |
title_full_unstemmed |
The effect of vitamin D supplementation on bone formation around titanium implants in diabetic rats |
title_sort |
effect of vitamin d supplementation on bone formation around titanium implants in diabetic rats |
publisher |
Wolters Kluwer Medknow Publications |
series |
Dental Research Journal |
issn |
1735-3327 2008-0255 |
publishDate |
2012-01-01 |
description |
Background: Diabetes has become the next most widespread disease after cancer. Recent studies have found that diabetes and moderate to severe vitamin D deficiency are associated with reduced bone mineral content; therefore administration of vitamin D may correct these conditions. The purpose of this research is to compare the effect of vitamin D administration on bone to implant contact in diabetic rats with control group.
Materials and Methods: In this randomized placebo-controlled trial, 48 Wistar rats were rendered diabetic (130≤ blood sugar ≤200 mg/dl) by IV injection of 35 mg/kg Alloxan. Implants were inserted in tibial bone; Then rats were divided into study and control groups and received oral vitamin D3 (160 IU) or placebo respectively for one week. Bone to implant contact value was measured under light microscope at 3 and 6 weeks.
Results: Analysis of data indicated that vitamin D had no significant effect on bone to implant contact (BIC). At 3 weeks, the control group (n = 5) reported BIC level at 44 ± 19 and study group (n = 7) at 57 ± 20. At 6 weeks, the control group (n = 5) reported BIC level at 70 ± 29, and study group (n = 10) at 65 ± 22. Twenty one samples were missed because of death or incorrect lab processes.
Conclusion: It seems that vitamin D supplement has no significant effect on BIC in 130 mg/dL ≤ blood sugar ≤200 mg/dL (P = 0.703) andwas also not time dependent (P = 0.074). |
topic |
Aloxan bone-implant contact type 2 diabetes vitamin D |
url |
http://www.drjjournal.net/article.asp?issn=1735-3327;year=2012;volume=9;issue=5;spage=582;epage=587;aulast=Akhavan |
work_keys_str_mv |
AT aliakhavan theeffectofvitamindsupplementationonboneformationaroundtitaniumimplantsindiabeticrats AT zahranoroozi theeffectofvitamindsupplementationonboneformationaroundtitaniumimplantsindiabeticrats AT amirabbasshafiei theeffectofvitamindsupplementationonboneformationaroundtitaniumimplantsindiabeticrats AT abbashaghighat theeffectofvitamindsupplementationonboneformationaroundtitaniumimplantsindiabeticrats AT gholamrezajahanshahi theeffectofvitamindsupplementationonboneformationaroundtitaniumimplantsindiabeticrats AT sayedbehrouzmousavi theeffectofvitamindsupplementationonboneformationaroundtitaniumimplantsindiabeticrats AT aliakhavan effectofvitamindsupplementationonboneformationaroundtitaniumimplantsindiabeticrats AT zahranoroozi effectofvitamindsupplementationonboneformationaroundtitaniumimplantsindiabeticrats AT amirabbasshafiei effectofvitamindsupplementationonboneformationaroundtitaniumimplantsindiabeticrats AT abbashaghighat effectofvitamindsupplementationonboneformationaroundtitaniumimplantsindiabeticrats AT gholamrezajahanshahi effectofvitamindsupplementationonboneformationaroundtitaniumimplantsindiabeticrats AT sayedbehrouzmousavi effectofvitamindsupplementationonboneformationaroundtitaniumimplantsindiabeticrats |
_version_ |
1724889874381668352 |