Mediation Analysis Supports a Causal Relationship between Maternal Hyperglycemia and Placental DNA Methylation Variations at the Leptin Gene Locus and Cord Blood Leptin Levels
Changes in fetal DNA methylation (DNAm) of the leptin (<i>LEP</i>) gene have been associated with exposure to maternal hyperglycemia, but their links with childhood obesity risk are still unclear. We investigated the association between maternal hyperglycemia, placental <i>LEP</...
Main Authors: | Valérie Gagné-Ouellet, Edith Breton, Kathrine Thibeault, Carol-Ann Fortin, Andres Cardenas, Renée Guérin, Patrice Perron, Marie-France Hivert, Luigi Bouchard |
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Format: | Article |
Language: | English |
Published: |
MDPI AG
2020-01-01
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Series: | International Journal of Molecular Sciences |
Subjects: | |
Online Access: | https://www.mdpi.com/1422-0067/21/1/329 |
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