Synthesis, Larvicidal Activities and Antifungal Activities of Novel Chlorantraniliprole Derivatives and Their Target in the Ryanodine Receptor

In order to identify novel chlorantraniliprole derivatives as potential insecticides or fungicides, 25 analogues of chlorantraniliprole were synthesized. The insecticidal activities against oriental armyworm and the antifungal activities against five typical fungi of these derivatives were tested. C...

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Main Authors:	Qichao Chen, Lixia Xiong, Min Luo, Jin Wang, Changyan Hu, Xiao Zhang, Shujing Yu, Yonghong Li, Dequn Sun
Format:	Article
Language:	English
Published:	MDPI AG 2015-03-01
Series:	Molecules
Subjects:	anthranilic diamides chlorantraniliprole ryanodine receptor insecticidal activities antifungal activities molecular docking
Online Access:	http://www.mdpi.com/1420-3049/20/3/3854

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spelling	doaj-531c34972449420f93d4d45bbce378242020-11-25T00:03:21ZengMDPI AGMolecules1420-30492015-03-012033854386710.3390/molecules20033854molecules20033854Synthesis, Larvicidal Activities and Antifungal Activities of Novel Chlorantraniliprole Derivatives and Their Target in the Ryanodine ReceptorQichao Chen0Lixia Xiong1Min Luo2Jin Wang3Changyan Hu4Xiao Zhang5Shujing Yu6Yonghong Li7Dequn Sun8Marine College, Shandong University at Weihai, No. 180, Wenhua West Road, Weihai 264209, ChinaState Key Laboratory of Elemento-Organic Chemistry, Institute of Elemento-Organic Chemistry, Nankai University, Tianjin 300071, ChinaMarine College, Shandong University at Weihai, No. 180, Wenhua West Road, Weihai 264209, ChinaMarine College, Shandong University at Weihai, No. 180, Wenhua West Road, Weihai 264209, ChinaMarine College, Shandong University at Weihai, No. 180, Wenhua West Road, Weihai 264209, ChinaState Key Laboratory of Elemento-Organic Chemistry, Institute of Elemento-Organic Chemistry, Nankai University, Tianjin 300071, ChinaState Key Laboratory of Elemento-Organic Chemistry, Institute of Elemento-Organic Chemistry, Nankai University, Tianjin 300071, ChinaState Key Laboratory of Elemento-Organic Chemistry, Institute of Elemento-Organic Chemistry, Nankai University, Tianjin 300071, ChinaMarine College, Shandong University at Weihai, No. 180, Wenhua West Road, Weihai 264209, ChinaIn order to identify novel chlorantraniliprole derivatives as potential insecticides or fungicides, 25 analogues of chlorantraniliprole were synthesized. The insecticidal activities against oriental armyworm and the antifungal activities against five typical fungi of these derivatives were tested. Compounds 2u, 2x and 2y exhibited good activities against oriental armyworm, especially compounds 2u and 2x which showed higher larvicidal activities than indoxacarb. Moreover, all of the tested compounds exhibited activities against five typical fungi. The Ki values of all synthesized compounds were calculated using AutoDock4. The relationship between the Ki values and the results of insecticidal activities against oriental armyworm further indicated that the membrane-spanning domain protein of the ryanodine receptor might contain chlorantraniliprole binding sites.http://www.mdpi.com/1420-3049/20/3/3854anthranilic diamideschlorantraniliproleryanodine receptorinsecticidal activitiesantifungal activitiesmolecular docking
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Qichao Chen Lixia Xiong Min Luo Jin Wang Changyan Hu Xiao Zhang Shujing Yu Yonghong Li Dequn Sun
spellingShingle	Qichao Chen Lixia Xiong Min Luo Jin Wang Changyan Hu Xiao Zhang Shujing Yu Yonghong Li Dequn Sun Synthesis, Larvicidal Activities and Antifungal Activities of Novel Chlorantraniliprole Derivatives and Their Target in the Ryanodine Receptor Molecules anthranilic diamides chlorantraniliprole ryanodine receptor insecticidal activities antifungal activities molecular docking
author_facet	Qichao Chen Lixia Xiong Min Luo Jin Wang Changyan Hu Xiao Zhang Shujing Yu Yonghong Li Dequn Sun
author_sort	Qichao Chen
title	Synthesis, Larvicidal Activities and Antifungal Activities of Novel Chlorantraniliprole Derivatives and Their Target in the Ryanodine Receptor
title_short	Synthesis, Larvicidal Activities and Antifungal Activities of Novel Chlorantraniliprole Derivatives and Their Target in the Ryanodine Receptor
title_full	Synthesis, Larvicidal Activities and Antifungal Activities of Novel Chlorantraniliprole Derivatives and Their Target in the Ryanodine Receptor
title_fullStr	Synthesis, Larvicidal Activities and Antifungal Activities of Novel Chlorantraniliprole Derivatives and Their Target in the Ryanodine Receptor
title_full_unstemmed	Synthesis, Larvicidal Activities and Antifungal Activities of Novel Chlorantraniliprole Derivatives and Their Target in the Ryanodine Receptor
title_sort	synthesis, larvicidal activities and antifungal activities of novel chlorantraniliprole derivatives and their target in the ryanodine receptor
publisher	MDPI AG
series	Molecules
issn	1420-3049
publishDate	2015-03-01
description	In order to identify novel chlorantraniliprole derivatives as potential insecticides or fungicides, 25 analogues of chlorantraniliprole were synthesized. The insecticidal activities against oriental armyworm and the antifungal activities against five typical fungi of these derivatives were tested. Compounds 2u, 2x and 2y exhibited good activities against oriental armyworm, especially compounds 2u and 2x which showed higher larvicidal activities than indoxacarb. Moreover, all of the tested compounds exhibited activities against five typical fungi. The Ki values of all synthesized compounds were calculated using AutoDock4. The relationship between the Ki values and the results of insecticidal activities against oriental armyworm further indicated that the membrane-spanning domain protein of the ryanodine receptor might contain chlorantraniliprole binding sites.
topic	anthranilic diamides chlorantraniliprole ryanodine receptor insecticidal activities antifungal activities molecular docking
url	http://www.mdpi.com/1420-3049/20/3/3854
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Synthesis, Larvicidal Activities and Antifungal Activities of Novel Chlorantraniliprole Derivatives and Their Target in the Ryanodine Receptor

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