Pregnancy at 40 years Old and Above: Obstetrical, Fetal, and Neonatal Outcomes. Is Age an Independent Risk Factor for Those Complications?
Objectives: Maternal age has been increasing for several decades with many of these late pregnancies between 40 and 45 years old. The main objective of this study is to assess whether maternal age is an independent factor of obstetric, fetal, and neonatal complications.Patients and methods: A monoce...
Main Authors: | , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Frontiers Media S.A.
2020-05-01
|
Series: | Frontiers in Medicine |
Subjects: | |
Online Access: | https://www.frontiersin.org/article/10.3389/fmed.2020.00208/full |
id |
doaj-531f36ff440743689c06440a75559058 |
---|---|
record_format |
Article |
spelling |
doaj-531f36ff440743689c06440a755590582020-11-25T02:33:00ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2020-05-01710.3389/fmed.2020.00208479707Pregnancy at 40 years Old and Above: Obstetrical, Fetal, and Neonatal Outcomes. Is Age an Independent Risk Factor for Those Complications?Ana Bouzaglou0Ines Aubenas1Hind Abbou2Stephanie Rouanet3Marie Carbonnel4Paul Pirtea5Jean Marc Bernard Ayoubi6Department of Gynecology and Obstetrics, Hospital Foch, Suresnes, FranceDepartment of Gynecology and Obstetrics, Hospital Foch, Suresnes, FranceDepartment of Gynecology and Obstetrics, Hospital Foch, Suresnes, FranceStatEthic SASU, Levallois Perret, FranceDepartment of Gynecology and Obstetrics, Hospital Foch, Suresnes, FranceDepartment of Gynecology and Obstetrics, Hospital Foch, Suresnes, FranceDepartment of Gynecology and Obstetrics, Hospital Foch, Suresnes, FranceObjectives: Maternal age has been increasing for several decades with many of these late pregnancies between 40 and 45 years old. The main objective of this study is to assess whether maternal age is an independent factor of obstetric, fetal, and neonatal complications.Patients and methods: A monocentric, French study “exposed-unexposed” was conducted during 11 years in a maternity level IIB. Maternal and perinatal outcomes were studied using univariates and multivariate analysis. We compared women aged 40 and above in a 1:1 ratio with women of 25–35 years old.Results: One thousand nine hundred eighty-two women were 40 or older (mean age: 41.9) on the day of their delivery and compared to other 1,982 women who were aged between 25 and 35 years old (mean age: 30.7) Preeclampsia, gestational diabetes, were significantly higher in the study group (4.6 vs. 1.5% and 14.5 vs. 6.9%, respectively, p < 0.001). We found also a significant difference for gestational hypertension (3.1 vs. 1.1% p < 0.001), preterm birth (10.4 vs. 6.5% p < 0.001), cesarean (16.6 vs. 5.4% for scheduled cesarean, and 50.4 vs. 13.9% for emergency cesarean, p < 0.001) and fetal death in utero (2.1 vs. 0.5% in the study group, p < 0.001). These results were also significantly different in multivariate analysis.Conclusion: A pregnancy after 40 years old is worth considering today as far as the risk factors are controlled and understand by the patient and the obstetrician. However, they have a significantly higher risks of cesarean, preterm delivery, pre-eclampsia, gestational diabetes, and fetal death in utero (FDIU). It is therefore the responsibility of the obstetrician to inform correctly these women in a detailed way, to reassure them and to adapt the monitoring of their pregnancy accordingly.https://www.frontiersin.org/article/10.3389/fmed.2020.00208/fulladvanced maternal agecomplicationneonatalpregnancypreeclampsiagestationnal diabetes |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Ana Bouzaglou Ines Aubenas Hind Abbou Stephanie Rouanet Marie Carbonnel Paul Pirtea Jean Marc Bernard Ayoubi |
spellingShingle |
Ana Bouzaglou Ines Aubenas Hind Abbou Stephanie Rouanet Marie Carbonnel Paul Pirtea Jean Marc Bernard Ayoubi Pregnancy at 40 years Old and Above: Obstetrical, Fetal, and Neonatal Outcomes. Is Age an Independent Risk Factor for Those Complications? Frontiers in Medicine advanced maternal age complication neonatal pregnancy preeclampsia gestationnal diabetes |
author_facet |
Ana Bouzaglou Ines Aubenas Hind Abbou Stephanie Rouanet Marie Carbonnel Paul Pirtea Jean Marc Bernard Ayoubi |
author_sort |
Ana Bouzaglou |
title |
Pregnancy at 40 years Old and Above: Obstetrical, Fetal, and Neonatal Outcomes. Is Age an Independent Risk Factor for Those Complications? |
title_short |
Pregnancy at 40 years Old and Above: Obstetrical, Fetal, and Neonatal Outcomes. Is Age an Independent Risk Factor for Those Complications? |
title_full |
Pregnancy at 40 years Old and Above: Obstetrical, Fetal, and Neonatal Outcomes. Is Age an Independent Risk Factor for Those Complications? |
title_fullStr |
Pregnancy at 40 years Old and Above: Obstetrical, Fetal, and Neonatal Outcomes. Is Age an Independent Risk Factor for Those Complications? |
title_full_unstemmed |
Pregnancy at 40 years Old and Above: Obstetrical, Fetal, and Neonatal Outcomes. Is Age an Independent Risk Factor for Those Complications? |
title_sort |
pregnancy at 40 years old and above: obstetrical, fetal, and neonatal outcomes. is age an independent risk factor for those complications? |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Medicine |
issn |
2296-858X |
publishDate |
2020-05-01 |
description |
Objectives: Maternal age has been increasing for several decades with many of these late pregnancies between 40 and 45 years old. The main objective of this study is to assess whether maternal age is an independent factor of obstetric, fetal, and neonatal complications.Patients and methods: A monocentric, French study “exposed-unexposed” was conducted during 11 years in a maternity level IIB. Maternal and perinatal outcomes were studied using univariates and multivariate analysis. We compared women aged 40 and above in a 1:1 ratio with women of 25–35 years old.Results: One thousand nine hundred eighty-two women were 40 or older (mean age: 41.9) on the day of their delivery and compared to other 1,982 women who were aged between 25 and 35 years old (mean age: 30.7) Preeclampsia, gestational diabetes, were significantly higher in the study group (4.6 vs. 1.5% and 14.5 vs. 6.9%, respectively, p < 0.001). We found also a significant difference for gestational hypertension (3.1 vs. 1.1% p < 0.001), preterm birth (10.4 vs. 6.5% p < 0.001), cesarean (16.6 vs. 5.4% for scheduled cesarean, and 50.4 vs. 13.9% for emergency cesarean, p < 0.001) and fetal death in utero (2.1 vs. 0.5% in the study group, p < 0.001). These results were also significantly different in multivariate analysis.Conclusion: A pregnancy after 40 years old is worth considering today as far as the risk factors are controlled and understand by the patient and the obstetrician. However, they have a significantly higher risks of cesarean, preterm delivery, pre-eclampsia, gestational diabetes, and fetal death in utero (FDIU). It is therefore the responsibility of the obstetrician to inform correctly these women in a detailed way, to reassure them and to adapt the monitoring of their pregnancy accordingly. |
topic |
advanced maternal age complication neonatal pregnancy preeclampsia gestationnal diabetes |
url |
https://www.frontiersin.org/article/10.3389/fmed.2020.00208/full |
work_keys_str_mv |
AT anabouzaglou pregnancyat40yearsoldandaboveobstetricalfetalandneonataloutcomesisageanindependentriskfactorforthosecomplications AT inesaubenas pregnancyat40yearsoldandaboveobstetricalfetalandneonataloutcomesisageanindependentriskfactorforthosecomplications AT hindabbou pregnancyat40yearsoldandaboveobstetricalfetalandneonataloutcomesisageanindependentriskfactorforthosecomplications AT stephanierouanet pregnancyat40yearsoldandaboveobstetricalfetalandneonataloutcomesisageanindependentriskfactorforthosecomplications AT mariecarbonnel pregnancyat40yearsoldandaboveobstetricalfetalandneonataloutcomesisageanindependentriskfactorforthosecomplications AT paulpirtea pregnancyat40yearsoldandaboveobstetricalfetalandneonataloutcomesisageanindependentriskfactorforthosecomplications AT jeanmarcbernardayoubi pregnancyat40yearsoldandaboveobstetricalfetalandneonataloutcomesisageanindependentriskfactorforthosecomplications |
_version_ |
1724816314725302272 |