The effect of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) on mice myocardial morphology

ABSTRACT: Studies have demonstrated sympathetic cardiac denervation in the MPTP mouse model. MPTP toxicity causes sympathetic nerve damage and depletion of heart norepinephrine. Previous evaluations of impairments in heart innervation have been based on imaging, electrophysiological and biochemical...

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Main Authors:	Tais H.C. Sasahara, Marcia R.F. Machado
Format:	Article
Language:	English
Published:	Colégio Brasileiro de Patologia Animal (CBPA)
Series:	Pesquisa Veterinária Brasileira
Subjects:	Methyl phenyl tetrahydropyridine MPTP mice myocardial morphology heart rodent stereology
Online Access:	http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-736X2019000500364&lng=en&tlng=en

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spelling	doaj-5320a5fd135c45978cabc8c35b4ad3d82020-11-24T21:37:58ZengColégio Brasileiro de Patologia Animal (CBPA)Pesquisa Veterinária Brasileira1678-515039536437010.1590/1678-5150-pvb-5808S0100-736X2019000500364The effect of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) on mice myocardial morphologyTais H.C. SasaharaMarcia R.F. MachadoABSTRACT: Studies have demonstrated sympathetic cardiac denervation in the MPTP mouse model. MPTP toxicity causes sympathetic nerve damage and depletion of heart norepinephrine. Previous evaluations of impairments in heart innervation have been based on imaging, electrophysiological and biochemical methods. However, these studies lacked information that can be obtained from morphoquantitative analyses. Thus, this study aimed to apply a design-based stereological method for evaluating the morphoquantitative alterations of myocardium following treatment with the neurotoxin MPTP in the C57/BL mouse. Our results showed that MPTP reduced the number of cardiomyocytes in the left ventricle.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-736X2019000500364&lng=en&tlng=enMethylphenyltetrahydropyridineMPTPmicemyocardialmorphologyheartrodentstereology
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Tais H.C. Sasahara Marcia R.F. Machado
spellingShingle	Tais H.C. Sasahara Marcia R.F. Machado The effect of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) on mice myocardial morphology Pesquisa Veterinária Brasileira Methyl phenyl tetrahydropyridine MPTP mice myocardial morphology heart rodent stereology
author_facet	Tais H.C. Sasahara Marcia R.F. Machado
author_sort	Tais H.C. Sasahara
title	The effect of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) on mice myocardial morphology
title_short	The effect of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) on mice myocardial morphology
title_full	The effect of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) on mice myocardial morphology
title_fullStr	The effect of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) on mice myocardial morphology
title_full_unstemmed	The effect of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) on mice myocardial morphology
title_sort	effect of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp) on mice myocardial morphology
publisher	Colégio Brasileiro de Patologia Animal (CBPA)
series	Pesquisa Veterinária Brasileira
issn	1678-5150
description	ABSTRACT: Studies have demonstrated sympathetic cardiac denervation in the MPTP mouse model. MPTP toxicity causes sympathetic nerve damage and depletion of heart norepinephrine. Previous evaluations of impairments in heart innervation have been based on imaging, electrophysiological and biochemical methods. However, these studies lacked information that can be obtained from morphoquantitative analyses. Thus, this study aimed to apply a design-based stereological method for evaluating the morphoquantitative alterations of myocardium following treatment with the neurotoxin MPTP in the C57/BL mouse. Our results showed that MPTP reduced the number of cardiomyocytes in the left ventricle.
topic	Methyl phenyl tetrahydropyridine MPTP mice myocardial morphology heart rodent stereology
url	http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-736X2019000500364&lng=en&tlng=en
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The effect of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) on mice myocardial morphology

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