Therapeutic effect of premixed insulin regimen and triple plus one combined therapy on type 2 diabetes

• Main Authors: Xing Chun-yan, Zhai Qing, Meng Xiang-jian, Yao Xin-ming
• Format: Article
• Language: English
• Published: Editorial Board of Journal of Hainan Medical University 2019-08-01
• Series: Journal of Hainan Medical University
• Subjects: type 2 diabetes; premixed insulin; blood sugar fluctuation level; blood glucose reaching standard time
• Online Access: http://www.hnykdxxb.com/PDF/201916/15

Objective: To analyze the level of blood glucose fluctuation and the time of blood glucose reaching the standard in the treatment of type 2 diabetes mellitus with premixed insulin regimen and three plus one intensive hypoglycemic regimen. Methods: A total of 120 patients with type 2 diabetes who were admitted to our hospital from April 2017 to April 2018 were divided into observation group and control group according to random number method, with 60 cases in each group. Patients in the control group were given insulin asparagus injection before breakfast and dinner, while patients in the observation group were given insulin Laipu injection before three meals combined with insulin glargine injection before bedtime. The insulin dosage, blood glucose compliance time, SDBG, CV, and quartile blood glucose fluctuation range were compared between the two groups. IQR, PPGE and other indicators of blood glucose fluctuations. Results: After treatment, the insulin dosage and blood glucose compliance time of the observation group were significantly lower than those of the control group (P<0.05). There was no significant difference in the incidence of hypoglycemia between the two groups (P>0.05). The SDBG, IQR, and PPGE of the day were significantly lower (P<0.05), and the CV was significantly higher (P<0.05). After two days of blood glucose compliance, the serum levels of SDBG, CV, IQR, and PPGE were significantly lower in the observation group than those in the control group (P<0.05). Conclusions: Compared with the premixed insulin regimen, the three plus one intensive hypoglycemic regimen has a better effect on controlling blood sugar fluctuation in type 2 diabetes mellitus, and the time for blood sugar to reach the standard is relatively short, and also the incidence of hypoglycemia is relatively low. Hence, it is worth popularizing in clinical practice.