Paraoxonase 1 as an important antiatherogenic agent

Paraoxonase 1 as an important antiatherogenic agent

The inverse relationship between High Density Lipoproteins (HDL) level and risk of ischaemic heart disease was proved by many epidemiological studies. Although the main mechanism of antiatherogenic activity of HDL is a reverse transport of cholesterol from peripheral tissues to the liver, HDL additi...

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Bibliographic Details
Main Authors: Ewa Lidia Krzewicka-Romaniuk, Dagna Agnieszka Siedlecka, Anna Warpas, Grażyna Wójcicka
Format: Article
Language:English
Published: Kazimierz Wielki University 2019-01-01
Series:Journal of Education, Health and Sport
Subjects:
paraoxonase
pon1
lipoproteins
hdl
antiatherogenic
Online Access:http://www.ojs.ukw.edu.pl/index.php/johs/article/view/6476
Description
Summary:The inverse relationship between High Density Lipoproteins (HDL) level and risk of ischaemic heart disease was proved by many epidemiological studies. Although the main mechanism of antiatherogenic activity of HDL is a reverse transport of cholesterol from peripheral tissues to the liver, HDL additionally carries some antioxidative enzymes like Paraoxonase 1 (PON1) which protects LDL and HDL lipoproteins from oxidative modification. A lot of antiatherogenic activities of HDL depends on PON1 activity.
ISSN:2391-8306

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