The Role of Exosomal miRNAs in Glioma: Biological Function and Clinical Application

The Role of Exosomal miRNAs in Glioma: Biological Function and Clinical Application

Gliomas are complex and heterogeneous central nervous system tumors with poor prognosis. Despite the increasing development of aggressive combination therapies, the prognosis of glioma is generally unsatisfactory. Exosomal microRNA (miRNA) has been successfully used in other diseases as a reliable b...

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Main Authors: Yirizhati Aili, Nuersimanguli Maimaitiming, Yusufu Mahemuti, Hu Qin, Yongxin Wang, Zengliang Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-09-01
Series:Frontiers in Oncology
Subjects:
glioma
exosomes
miRNA
microenvironment
biomarkers
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2021.686369/full
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spelling doaj-53330df7de984a3bae99cc1e229aad492021-09-04T01:37:55ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2021-09-011110.3389/fonc.2021.686369686369The Role of Exosomal miRNAs in Glioma: Biological Function and Clinical ApplicationYirizhati Aili0Nuersimanguli Maimaitiming1Yusufu Mahemuti2Hu Qin3Yongxin Wang4Zengliang Wang5Department of Neurosurgery, The First Affiliated Hospital of Xinjiang Medical University, Xinjiang, ChinaDepartment of Oncology, The First Affiliated Hospital of Xinjiang Medical University, Xinjiang, ChinaDepartment of Neurosurgery, The First Affiliated Hospital of Xinjiang Medical University, Xinjiang, ChinaDepartment of Neurosurgery, The First Affiliated Hospital of Xinjiang Medical University, Xinjiang, ChinaDepartment of Neurosurgery, The First Affiliated Hospital of Xinjiang Medical University, Xinjiang, ChinaDepartment of Neurosurgery, The First Affiliated Hospital of Xinjiang Medical University, Xinjiang, ChinaGliomas are complex and heterogeneous central nervous system tumors with poor prognosis. Despite the increasing development of aggressive combination therapies, the prognosis of glioma is generally unsatisfactory. Exosomal microRNA (miRNA) has been successfully used in other diseases as a reliable biomarker and even therapeutic target. Recent studies show that exosomal miRNA plays an important role in glioma occurrence, development, invasion, metastasis, and treatment resistance. However, the association of exosomal miRNA between glioma has not been systemically characterized. This will provide a theoretical basis for us to further explore the relationship between exosomal miRNAs and glioma and also has a positive clinical significance in the innovative diagnosis and treatment of glioma.https://www.frontiersin.org/articles/10.3389/fonc.2021.686369/fullgliomaexosomesmiRNAmicroenvironmentbiomarkers
collection DOAJ
language English
format Article
sources DOAJ
author Yirizhati Aili
Nuersimanguli Maimaitiming
Yusufu Mahemuti
Hu Qin
Yongxin Wang
Zengliang Wang
spellingShingle Yirizhati Aili
Nuersimanguli Maimaitiming
Yusufu Mahemuti
Hu Qin
Yongxin Wang
Zengliang Wang
The Role of Exosomal miRNAs in Glioma: Biological Function and Clinical Application
Frontiers in Oncology
glioma
exosomes
miRNA
microenvironment
biomarkers
author_facet Yirizhati Aili
Nuersimanguli Maimaitiming
Yusufu Mahemuti
Hu Qin
Yongxin Wang
Zengliang Wang
author_sort Yirizhati Aili
title The Role of Exosomal miRNAs in Glioma: Biological Function and Clinical Application
title_short The Role of Exosomal miRNAs in Glioma: Biological Function and Clinical Application
title_full The Role of Exosomal miRNAs in Glioma: Biological Function and Clinical Application
title_fullStr The Role of Exosomal miRNAs in Glioma: Biological Function and Clinical Application
title_full_unstemmed The Role of Exosomal miRNAs in Glioma: Biological Function and Clinical Application
title_sort role of exosomal mirnas in glioma: biological function and clinical application
publisher Frontiers Media S.A.
series Frontiers in Oncology
issn 2234-943X
publishDate 2021-09-01
description Gliomas are complex and heterogeneous central nervous system tumors with poor prognosis. Despite the increasing development of aggressive combination therapies, the prognosis of glioma is generally unsatisfactory. Exosomal microRNA (miRNA) has been successfully used in other diseases as a reliable biomarker and even therapeutic target. Recent studies show that exosomal miRNA plays an important role in glioma occurrence, development, invasion, metastasis, and treatment resistance. However, the association of exosomal miRNA between glioma has not been systemically characterized. This will provide a theoretical basis for us to further explore the relationship between exosomal miRNAs and glioma and also has a positive clinical significance in the innovative diagnosis and treatment of glioma.
topic glioma
exosomes
miRNA
microenvironment
biomarkers
url https://www.frontiersin.org/articles/10.3389/fonc.2021.686369/full
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