Factors in an Auto-Brewery Syndrome group compared to an American Gut Project group: a case-control study [version 1; peer review: 2 approved]
Background: Auto-Brewery Syndrome (ABS), also known as Gut Fermentation Syndrome, is a rare but underdiagnosed condition. While scores of case studies of ABS are published, only one previous study examined ABS patients’ demographics, health history, lifestyle factors, and diet compared to a control...
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doaj-5337fbff89aa4273a148e684a3a5f7a72021-09-14T11:02:37ZengF1000 Research LtdF1000Research2046-14022021-06-011010.12688/f1000research.52743.156059Factors in an Auto-Brewery Syndrome group compared to an American Gut Project group: a case-control study [version 1; peer review: 2 approved]Barbara Cordell0Anup Kanodia1Gregory K. Miller2Department of Nursing, Panola College, Carthage, TX, 75633, USAOhio State University Medical Center, Columbus, OH, 43210, USADepartment of Statistics, Stephen F. Austin State University, Nacogdoches, TX, 75962, USABackground: Auto-Brewery Syndrome (ABS), also known as Gut Fermentation Syndrome, is a rare but underdiagnosed condition. While scores of case studies of ABS are published, only one previous study examined ABS patients’ demographics, health history, lifestyle factors, and diet compared to a control group of household members. Methods: We designed a case-control study to identify factors that individuals with a diagnosis of ABS and those who live with them might have that differ from a larger general group. We administered a survey to 46 patients known to have a diagnosis of ABS and their household members. Here, we compare our group of survey takers to a cohort of the American Gut Project (AGP) participants (N=11,297) for the 30 questions that were identical. Results: With a response rate of 88% and using Rank Sum Tests, the data demonstrate that patients with ABS and their household members are more likely than participants of the AGP to own a pet (p=.03 for cat; p=.0001 for dog), get less sleep (p=.0001), and have lesser quality of bowel movements (p=.03). In addition, the ABS group consumes more water (p=.02) and less alcohol (p=.0004), eats at home more often (p=.0056), and reports more aversion to sweets (p=.01). The most striking difference is a higher presence of non-food allergies in all five subcategories of the survey in the ABS group compared to the AGP group. Conclusion: Patients with ABS and their household members show several significant differences in their lifestyle and health, diet, and medical history compared to a large group of AGP participants. These differences lead to several hypotheses about co-morbidities that warrant further research.https://f1000research.com/articles/10-457/v1 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Barbara Cordell Anup Kanodia Gregory K. Miller |
spellingShingle |
Barbara Cordell Anup Kanodia Gregory K. Miller Factors in an Auto-Brewery Syndrome group compared to an American Gut Project group: a case-control study [version 1; peer review: 2 approved] F1000Research |
author_facet |
Barbara Cordell Anup Kanodia Gregory K. Miller |
author_sort |
Barbara Cordell |
title |
Factors in an Auto-Brewery Syndrome group compared to an American Gut Project group: a case-control study [version 1; peer review: 2 approved] |
title_short |
Factors in an Auto-Brewery Syndrome group compared to an American Gut Project group: a case-control study [version 1; peer review: 2 approved] |
title_full |
Factors in an Auto-Brewery Syndrome group compared to an American Gut Project group: a case-control study [version 1; peer review: 2 approved] |
title_fullStr |
Factors in an Auto-Brewery Syndrome group compared to an American Gut Project group: a case-control study [version 1; peer review: 2 approved] |
title_full_unstemmed |
Factors in an Auto-Brewery Syndrome group compared to an American Gut Project group: a case-control study [version 1; peer review: 2 approved] |
title_sort |
factors in an auto-brewery syndrome group compared to an american gut project group: a case-control study [version 1; peer review: 2 approved] |
publisher |
F1000 Research Ltd |
series |
F1000Research |
issn |
2046-1402 |
publishDate |
2021-06-01 |
description |
Background: Auto-Brewery Syndrome (ABS), also known as Gut Fermentation Syndrome, is a rare but underdiagnosed condition. While scores of case studies of ABS are published, only one previous study examined ABS patients’ demographics, health history, lifestyle factors, and diet compared to a control group of household members. Methods: We designed a case-control study to identify factors that individuals with a diagnosis of ABS and those who live with them might have that differ from a larger general group. We administered a survey to 46 patients known to have a diagnosis of ABS and their household members. Here, we compare our group of survey takers to a cohort of the American Gut Project (AGP) participants (N=11,297) for the 30 questions that were identical. Results: With a response rate of 88% and using Rank Sum Tests, the data demonstrate that patients with ABS and their household members are more likely than participants of the AGP to own a pet (p=.03 for cat; p=.0001 for dog), get less sleep (p=.0001), and have lesser quality of bowel movements (p=.03). In addition, the ABS group consumes more water (p=.02) and less alcohol (p=.0004), eats at home more often (p=.0056), and reports more aversion to sweets (p=.01). The most striking difference is a higher presence of non-food allergies in all five subcategories of the survey in the ABS group compared to the AGP group. Conclusion: Patients with ABS and their household members show several significant differences in their lifestyle and health, diet, and medical history compared to a large group of AGP participants. These differences lead to several hypotheses about co-morbidities that warrant further research. |
url |
https://f1000research.com/articles/10-457/v1 |
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