Manifestations of food protein induced gastrointestinal allergies presenting to a single tertiary paediatric gastroenterology unit
Background Food protein induced gastrointestinal allergies are difficult to characterise due to the delayed nature of this allergy and absence of simple diagnostic tests. Diagnosis is based on an allergy focused history which can be challenging and often yields ambiguous results. We therefore set ou...
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doaj-533f7ea9044743d8800cf51ede1331252020-11-25T01:34:57ZengElsevierWorld Allergy Organization Journal1939-45512013-01-016Manifestations of food protein induced gastrointestinal allergies presenting to a single tertiary paediatric gastroenterology unitRosan Meyer0Catharine Fleming1Gloria Dominguez-Ortega2Keith Lindley3Louise Michaelis4Nikhil Thapar5Mamoun Elawad6Vijay Chakravarti7Adam T Fox8Neil Shah9Department of Gastroenterology, Great Ormond Street Children’s Hospital, Great Ormond Street, London WC1N 3JH, UK; Correspondence:Centre for Children’s Cancer and Blood Disorders, Sydney Children’s Hospital, Sydney, AustraliaDepartment of Gastroenterology, Great Ormond Street Children’s Hospital, Great Ormond Street, London WC1N 3JH, UKDepartment of Gastroenterology, Great Ormond Street Children’s Hospital, Great Ormond Street, London WC1N 3JH, UKFaculty of Medicine and Health and Life Science, University of Southampton, Southampton SO171BJ, UKDepartment of Gastroenterology, Great Ormond Street Children’s Hospital, Great Ormond Street, London WC1N 3JH, UKDepartment of Gastroenterology, Great Ormond Street Children’s Hospital, Great Ormond Street, London WC1N 3JH, UKPrincess Alexandra Hospital NHS Trust, Harlow, Essex CM20 1QX, UKMRC & Asthma UK Centre in Allergic Mechanisms of Asthma, Division of Asthma, Allergy and Lung Biology, Guy’s and St Thomas’ NHS Foundation Trust, King’s College London, London SE1 7EH, UKDepartment of Gastroenterology, Great Ormond Street Children’s Hospital, Great Ormond Street, London WC1N 3JH, UKBackground Food protein induced gastrointestinal allergies are difficult to characterise due to the delayed nature of this allergy and absence of simple diagnostic tests. Diagnosis is based on an allergy focused history which can be challenging and often yields ambiguous results. We therefore set out to describe a group of children with this delayed type allergy, to provide an overview on typical profile, symptoms and management strategies.Methods This retrospective analysis was performed at Great Ormond Street Children’s Hospital. Medical notes were included from 2002 – 2009 where a documented medical diagnosis of food protein induced gastrointestinal allergies was confirmed by an elimination diet with resolution of symptoms, followed by reintroduction with reoccurrence of symptoms. Age of onset of symptoms, diagnosis, current elimination diets and food elimination at time of diagnosis and co-morbidities were collected and parents were phoned again at the time of data collection to ascertain current allergy status.Results Data from 437 children were analysis. The majority (67.7%) of children had an atopic family history and 41.5% had atopic dermatitis at an early age. The most common diagnosis included, non-IgE mediated gastrointestinal food allergy (n = 189) and allergic enterocolitis (n = 154) with symptoms of: vomiting (57.8%), back-arching and screaming (50%), constipation (44.6%), diarrhoea (81%), abdominal pain (89.9%), abdominal bloating (73.9%) and rectal bleeding (38.5%). The majority of patients were initially managed with a milk, soy, egg and wheat free diet (41.7%). At a median age of 8 years, 24.7% of children still required to eliminate some of the food allergens.Conclusions This large retrospective study on children with food induced gastrointestinal allergies highlights the variety of symptoms and treatment modalities used in these children. However, further prospective studies are required in this area of food allergy.http://www.sciencedirect.com/science/article/pii/S1939455119306350 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Rosan Meyer Catharine Fleming Gloria Dominguez-Ortega Keith Lindley Louise Michaelis Nikhil Thapar Mamoun Elawad Vijay Chakravarti Adam T Fox Neil Shah |
spellingShingle |
Rosan Meyer Catharine Fleming Gloria Dominguez-Ortega Keith Lindley Louise Michaelis Nikhil Thapar Mamoun Elawad Vijay Chakravarti Adam T Fox Neil Shah Manifestations of food protein induced gastrointestinal allergies presenting to a single tertiary paediatric gastroenterology unit World Allergy Organization Journal |
author_facet |
Rosan Meyer Catharine Fleming Gloria Dominguez-Ortega Keith Lindley Louise Michaelis Nikhil Thapar Mamoun Elawad Vijay Chakravarti Adam T Fox Neil Shah |
author_sort |
Rosan Meyer |
title |
Manifestations of food protein induced gastrointestinal allergies presenting to a single tertiary paediatric gastroenterology unit |
title_short |
Manifestations of food protein induced gastrointestinal allergies presenting to a single tertiary paediatric gastroenterology unit |
title_full |
Manifestations of food protein induced gastrointestinal allergies presenting to a single tertiary paediatric gastroenterology unit |
title_fullStr |
Manifestations of food protein induced gastrointestinal allergies presenting to a single tertiary paediatric gastroenterology unit |
title_full_unstemmed |
Manifestations of food protein induced gastrointestinal allergies presenting to a single tertiary paediatric gastroenterology unit |
title_sort |
manifestations of food protein induced gastrointestinal allergies presenting to a single tertiary paediatric gastroenterology unit |
publisher |
Elsevier |
series |
World Allergy Organization Journal |
issn |
1939-4551 |
publishDate |
2013-01-01 |
description |
Background Food protein induced gastrointestinal allergies are difficult to characterise due to the delayed nature of this allergy and absence of simple diagnostic tests. Diagnosis is based on an allergy focused history which can be challenging and often yields ambiguous results. We therefore set out to describe a group of children with this delayed type allergy, to provide an overview on typical profile, symptoms and management strategies.Methods This retrospective analysis was performed at Great Ormond Street Children’s Hospital. Medical notes were included from 2002 – 2009 where a documented medical diagnosis of food protein induced gastrointestinal allergies was confirmed by an elimination diet with resolution of symptoms, followed by reintroduction with reoccurrence of symptoms. Age of onset of symptoms, diagnosis, current elimination diets and food elimination at time of diagnosis and co-morbidities were collected and parents were phoned again at the time of data collection to ascertain current allergy status.Results Data from 437 children were analysis. The majority (67.7%) of children had an atopic family history and 41.5% had atopic dermatitis at an early age. The most common diagnosis included, non-IgE mediated gastrointestinal food allergy (n = 189) and allergic enterocolitis (n = 154) with symptoms of: vomiting (57.8%), back-arching and screaming (50%), constipation (44.6%), diarrhoea (81%), abdominal pain (89.9%), abdominal bloating (73.9%) and rectal bleeding (38.5%). The majority of patients were initially managed with a milk, soy, egg and wheat free diet (41.7%). At a median age of 8 years, 24.7% of children still required to eliminate some of the food allergens.Conclusions This large retrospective study on children with food induced gastrointestinal allergies highlights the variety of symptoms and treatment modalities used in these children. However, further prospective studies are required in this area of food allergy. |
url |
http://www.sciencedirect.com/science/article/pii/S1939455119306350 |
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