Cross protective immune responses in nursing piglets infected with a US spike-insertion deletion porcine epidemic diarrhea virus strain and challenged with an original US PEDV strain

• Main Authors: Thavamathi Annamalai, Chun-Ming Lin, Xiang Gao, Xinsheng Liu, Zhongyan Lu, Linda J. Saif, Qiuhong Wang
• Format: Article
• Language: English
• Published: BMC 2017-10-01
• Series: Veterinary Research
• Online Access: http://link.springer.com/article/10.1186/s13567-017-0469-7

Abstract We investigated cross-protective immunity of a US spike-insertion deletion porcine epidemic diarrhea virus (PEDV) Iowa106 (S-INDEL) strain against the original US PEDV (PC21A) strain in nursing piglets. Piglets were inoculated orally with S-INDEL, PC21A or mock. At 20–29 days post-inoculation (dpi), all pigs were challenged with the PC21A strain. The S-INDEL-inoculated pigs had lower ileal IgA antibody secreting cells, serum IgA and neutralizing antibody titers compared with PC21A-inoculated pigs. No pigs in the PC21A-group developed diarrhea, whereas 81 and 100% of pigs in the S-INDEL and mock-groups had diarrhea post challenge, respectively. S-INDEL induced partial protective immunity against the original US PEDV strain.