The 5HT1a receptor agonist 8-Oh DPAT induces protection from lipofuscin accumulation and oxidative stress in the retinal pigment epithelium.

The 5HT1a receptor agonist 8-Oh DPAT induces protection from lipofuscin accumulation and oxidative stress in the retinal pigment epithelium.

Age-related macular degeneration (AMD), a major cause of blindness in the elderly, is associated with oxidative stress, lipofuscin accumulation and retinal degeneration. The aim of this study was to determine if a 5-HT(1A) receptor agonist can reduce lipofuscin accumulation, reduce oxidative damage...

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Bibliographic Details
Main Authors: Prajitha Thampi, Haripriya Vittal Rao, Sayak K Mitter, Jun Cai, Haoyu Mao, Hong Li, Soojung Seo, Xiaoping Qi, Alfred S Lewin, Carl Romano, Michael E Boulton
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3317995?pdf=render

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