Whole-brain structural topology in adult attention-deficit/hyperactivity disorder: Preserved global – disturbed local network organization
Prior studies demonstrate altered organization of functional brain networks in attention-deficit/hyperactivity disorder (ADHD). However, the structural underpinnings of these functional disturbances are poorly understood. In the current study, we applied a graph-theoretic approach to whole-brain dif...
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doaj-5358cfbf66f34ddba4a0cd948a2374342020-11-24T20:48:22ZengElsevierNeuroImage: Clinical2213-15822015-01-019C50651210.1016/j.nicl.2015.10.001Whole-brain structural topology in adult attention-deficit/hyperactivity disorder: Preserved global – disturbed local network organizationJustina Sidlauskaite0Karen Caeyenberghs1Edmund Sonuga-Barke2Herbert Roeyers3Jan R. Wiersema4Department of Experimental–Clinical and Health Psychology, Ghent University, Henri Dunantlaan 2, Ghent B-9000, BelgiumSchool of Psychology, Faculty of Health Sciences, Australian Catholic University, 115 Victoria Parade, Melbourne, VIC 3065, AustraliaDepartment of Experimental–Clinical and Health Psychology, Ghent University, Henri Dunantlaan 2, Ghent B-9000, BelgiumDepartment of Experimental–Clinical and Health Psychology, Ghent University, Henri Dunantlaan 2, Ghent B-9000, BelgiumDepartment of Experimental–Clinical and Health Psychology, Ghent University, Henri Dunantlaan 2, Ghent B-9000, BelgiumPrior studies demonstrate altered organization of functional brain networks in attention-deficit/hyperactivity disorder (ADHD). However, the structural underpinnings of these functional disturbances are poorly understood. In the current study, we applied a graph-theoretic approach to whole-brain diffusion magnetic resonance imaging data to investigate the organization of structural brain networks in adults with ADHD and unaffected controls using deterministic fiber tractography. Groups did not differ in terms of global network metrics — small-worldness, global efficiency and clustering coefficient. However, there were widespread ADHD-related effects at the nodal level in relation to local efficiency and clustering. The affected nodes included superior occipital, supramarginal, superior temporal, inferior parietal, angular and inferior frontal gyri, as well as putamen, thalamus and posterior cerebellum. Lower local efficiency of left superior temporal and supramarginal gyri was associated with higher ADHD symptom scores. Also greater local clustering of right putamen and lower local clustering of left supramarginal gyrus correlated with ADHD symptom severity. Overall, the findings indicate preserved global but altered local network organization in adult ADHD implicating regions underpinning putative ADHD-related neuropsychological deficits.http://www.sciencedirect.com/science/article/pii/S2213158215300012Attention deficit/hyperactivity disorderDiffusion MRIDeterministic tractographyGraph theory |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Justina Sidlauskaite Karen Caeyenberghs Edmund Sonuga-Barke Herbert Roeyers Jan R. Wiersema |
spellingShingle |
Justina Sidlauskaite Karen Caeyenberghs Edmund Sonuga-Barke Herbert Roeyers Jan R. Wiersema Whole-brain structural topology in adult attention-deficit/hyperactivity disorder: Preserved global – disturbed local network organization NeuroImage: Clinical Attention deficit/hyperactivity disorder Diffusion MRI Deterministic tractography Graph theory |
author_facet |
Justina Sidlauskaite Karen Caeyenberghs Edmund Sonuga-Barke Herbert Roeyers Jan R. Wiersema |
author_sort |
Justina Sidlauskaite |
title |
Whole-brain structural topology in adult attention-deficit/hyperactivity disorder: Preserved global – disturbed local network organization |
title_short |
Whole-brain structural topology in adult attention-deficit/hyperactivity disorder: Preserved global – disturbed local network organization |
title_full |
Whole-brain structural topology in adult attention-deficit/hyperactivity disorder: Preserved global – disturbed local network organization |
title_fullStr |
Whole-brain structural topology in adult attention-deficit/hyperactivity disorder: Preserved global – disturbed local network organization |
title_full_unstemmed |
Whole-brain structural topology in adult attention-deficit/hyperactivity disorder: Preserved global – disturbed local network organization |
title_sort |
whole-brain structural topology in adult attention-deficit/hyperactivity disorder: preserved global – disturbed local network organization |
publisher |
Elsevier |
series |
NeuroImage: Clinical |
issn |
2213-1582 |
publishDate |
2015-01-01 |
description |
Prior studies demonstrate altered organization of functional brain networks in attention-deficit/hyperactivity disorder (ADHD). However, the structural underpinnings of these functional disturbances are poorly understood. In the current study, we applied a graph-theoretic approach to whole-brain diffusion magnetic resonance imaging data to investigate the organization of structural brain networks in adults with ADHD and unaffected controls using deterministic fiber tractography. Groups did not differ in terms of global network metrics — small-worldness, global efficiency and clustering coefficient. However, there were widespread ADHD-related effects at the nodal level in relation to local efficiency and clustering. The affected nodes included superior occipital, supramarginal, superior temporal, inferior parietal, angular and inferior frontal gyri, as well as putamen, thalamus and posterior cerebellum. Lower local efficiency of left superior temporal and supramarginal gyri was associated with higher ADHD symptom scores. Also greater local clustering of right putamen and lower local clustering of left supramarginal gyrus correlated with ADHD symptom severity. Overall, the findings indicate preserved global but altered local network organization in adult ADHD implicating regions underpinning putative ADHD-related neuropsychological deficits. |
topic |
Attention deficit/hyperactivity disorder Diffusion MRI Deterministic tractography Graph theory |
url |
http://www.sciencedirect.com/science/article/pii/S2213158215300012 |
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