Bacterial profile and antibiotic susceptibility pattern of adult lower respiratory tract infections in Colombo, Sri Lanka
Introduction: Lower respiratory tract infections (LRTIs) remain the deadliest communicable disease around the world. This study was conducted to identify the bacterial etiology of LRTIs among patients who attended the Central Chest Clinic in city of Colombo, Sri Lanka and their antibiotic susceptibi...
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doaj-535dc9d0e64f4e34b913ea7f72fe395a2020-11-25T00:16:01ZengEdizioni FSJournal of Health and Social Sciences2499-22402499-58862018-03-0131273610.19204/2018/bctr3Bacterial profile and antibiotic susceptibility pattern of adult lower respiratory tract infections in Colombo, Sri LankaNadeesha Amarasinghe0Muthulingam Athavan1Deepal Jayamanne2Yamuna Rajapakshe3Aflah Sadikeen4Kirthi Gunasekara5Amitha Fernando6Lilani Karunanayake7 Central Chest Clinic, Colombo, Sri LankaCentral Chest Clinic, Colombo, Sri LankaHealth Informatics, Ministry of Health, Colombo, Sri Lanka Central Chest Clinic, Colombo, Sri Lanka Central Chest Clinic, Colombo, Sri Lanka Central Chest Clinic, Colombo, Sri Lanka Central Chest Clinic, Colombo, Sri Lanka Medical Research Institute, Colombo, Sri Lanka.Introduction: Lower respiratory tract infections (LRTIs) remain the deadliest communicable disease around the world. This study was conducted to identify the bacterial etiology of LRTIs among patients who attended the Central Chest Clinic in city of Colombo, Sri Lanka and their antibiotic susceptibility profile to enable clinicians to take decisions on effective empirical antibiotics. Methods: Sputum samples were collected from 1,372 patients over the age of 18 years with suspected LRTIs during the year 2015. The samples were collected and processed according to standard laboratory procedures at the microbiology laboratory of the Medical Research Institute of Sri Lanka. Results: Most of reports (58%) were from patients diagnosed with infective exacerbations of chronic lung diseases. Out of all sputum cultures processed, 404 (29.4%) resulted positive for pathogenic bacterial organisms. Coliforms (n = 176, 43.6%), and Pseudomonas aeruginosa (n = 117, 29%) were the most common isolated bacteria, followed by Moraxella (n = 47, 11.6%), Haemophilus influenzae (n = 23, 5.7%), and Streptococcus pneumoniae (n = 18, 4.4%). The two most common bacteria isolated showed a high sensitivity for co-amoxyclav, quinolones, 3rd generation cephalosporins, carbapenems and aminoglycosides, while coliforms were highly resistant (98%) to ampicillin. S. pneumoniae showed a high resistance for penicillin (67%) and erythromycin (61%), while Haemophilus showed a good sensitivity to co-amoxyclav (96%). There was no significant correlation between rainfall and proportions of coliforms (r = - 0.152, P = 0.638) and Pseudomonas (r = 0.271, P = 0.395) during the year. Discussion and Conclusion: In our study, the most predominant pathogens recovered from LRTIs were P. aeruginosa and coliforms (Klebsiella spp.) as Gram negative, and S. pneumoniae as Gram positive bacteria. Co-amoxyclav, 3rd generation cephalosporins, quinolones and all second line antibiotics tested were the most efficient antibiotics in treatment of LRTIs, differently from ampicillin, erythromycin and penicillin that were not efficient antibiotics in treating this disease in our locality. http://journalhss.com/wp-content/uploads/jhss31_27-36.pdfchronic obstructive pulmonary disease; lower respiratory tract infections; Sri Lanka.Antibiotic susceptibilityantibiotic resistancebronchiectasischronic obstructive pulmonary diseaselower respiratory tract infectionSri Lanka |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Nadeesha Amarasinghe Muthulingam Athavan Deepal Jayamanne Yamuna Rajapakshe Aflah Sadikeen Kirthi Gunasekara Amitha Fernando Lilani Karunanayake |
spellingShingle |
Nadeesha Amarasinghe Muthulingam Athavan Deepal Jayamanne Yamuna Rajapakshe Aflah Sadikeen Kirthi Gunasekara Amitha Fernando Lilani Karunanayake Bacterial profile and antibiotic susceptibility pattern of adult lower respiratory tract infections in Colombo, Sri Lanka Journal of Health and Social Sciences chronic obstructive pulmonary disease; lower respiratory tract infections; Sri Lanka. Antibiotic susceptibility antibiotic resistance bronchiectasis chronic obstructive pulmonary disease lower respiratory tract infection Sri Lanka |
author_facet |
Nadeesha Amarasinghe Muthulingam Athavan Deepal Jayamanne Yamuna Rajapakshe Aflah Sadikeen Kirthi Gunasekara Amitha Fernando Lilani Karunanayake |
author_sort |
Nadeesha Amarasinghe |
title |
Bacterial profile and antibiotic susceptibility pattern of adult lower respiratory tract infections in Colombo, Sri Lanka |
title_short |
Bacterial profile and antibiotic susceptibility pattern of adult lower respiratory tract infections in Colombo, Sri Lanka |
title_full |
Bacterial profile and antibiotic susceptibility pattern of adult lower respiratory tract infections in Colombo, Sri Lanka |
title_fullStr |
Bacterial profile and antibiotic susceptibility pattern of adult lower respiratory tract infections in Colombo, Sri Lanka |
title_full_unstemmed |
Bacterial profile and antibiotic susceptibility pattern of adult lower respiratory tract infections in Colombo, Sri Lanka |
title_sort |
bacterial profile and antibiotic susceptibility pattern of adult lower respiratory tract infections in colombo, sri lanka |
publisher |
Edizioni FS |
series |
Journal of Health and Social Sciences |
issn |
2499-2240 2499-5886 |
publishDate |
2018-03-01 |
description |
Introduction: Lower respiratory tract infections (LRTIs) remain the deadliest communicable disease around the world. This study was conducted to identify the bacterial etiology of LRTIs among patients who attended the Central Chest Clinic in city of Colombo, Sri Lanka and their antibiotic susceptibility profile to enable clinicians to take decisions on effective empirical antibiotics.
Methods: Sputum samples were collected from 1,372 patients over the age of 18 years with suspected LRTIs during the year 2015. The samples were collected and processed according to standard laboratory procedures at the microbiology laboratory of the Medical Research Institute of Sri Lanka.
Results: Most of reports (58%) were from patients diagnosed with infective exacerbations of chronic lung diseases. Out of all sputum cultures processed, 404 (29.4%) resulted positive for pathogenic bacterial organisms. Coliforms (n = 176, 43.6%), and Pseudomonas aeruginosa (n = 117, 29%) were the most common
isolated bacteria, followed by Moraxella (n = 47, 11.6%), Haemophilus influenzae (n = 23, 5.7%), and Streptococcus pneumoniae (n = 18, 4.4%). The two most common bacteria isolated showed a high sensitivity for co-amoxyclav, quinolones, 3rd generation cephalosporins, carbapenems and aminoglycosides, while coliforms were highly resistant (98%) to ampicillin. S. pneumoniae showed a high resistance for penicillin
(67%) and erythromycin (61%), while Haemophilus showed a good sensitivity to co-amoxyclav (96%). There was no significant correlation between rainfall and proportions of coliforms (r = - 0.152, P = 0.638) and Pseudomonas (r = 0.271, P = 0.395) during the year.
Discussion and Conclusion: In our study, the most predominant pathogens recovered from LRTIs were P. aeruginosa and coliforms (Klebsiella spp.) as Gram negative, and S. pneumoniae as Gram positive bacteria. Co-amoxyclav, 3rd generation cephalosporins, quinolones and all second line antibiotics tested were the most efficient antibiotics in treatment of LRTIs, differently from ampicillin, erythromycin and penicillin that were not efficient antibiotics in treating this disease in our locality. |
topic |
chronic obstructive pulmonary disease; lower respiratory tract infections; Sri Lanka. Antibiotic susceptibility antibiotic resistance bronchiectasis chronic obstructive pulmonary disease lower respiratory tract infection Sri Lanka |
url |
http://journalhss.com/wp-content/uploads/jhss31_27-36.pdf |
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