Taming the Boys for Global Good: Contraceptive Strategy to Stop Malaria Transmission
Transmission of human malaria parasites (<i>Plasmodium</i> spp.) by <i>Anopheles</i> mosquitoes is a continuous process that presents a formidable challenge for effective control of the disease. Infectious gametocytes continue to circulate in humans for up to four weeks after...
Main Authors: | , , , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
MDPI AG
2020-06-01
|
Series: | Molecules |
Subjects: | |
Online Access: | https://www.mdpi.com/1420-3049/25/12/2773 |
id |
doaj-536274f939304bdbab45b7bfee39c93a |
---|---|
record_format |
Article |
spelling |
doaj-536274f939304bdbab45b7bfee39c93a2020-11-25T02:58:18ZengMDPI AGMolecules1420-30492020-06-01252773277310.3390/molecules25122773Taming the Boys for Global Good: Contraceptive Strategy to Stop Malaria TransmissionRyan Choi0Samantha A. Michaels1Emmanuel C. Onu2Matthew A. Hulverson3Aparajita Saha4Morenike E. Coker5Janis C. Weeks6Wesley C. Van Voorhis7Kayode K. Ojo8Center for Emerging and Re-emerging Infectious Diseases (CERID), Division of Allergy and Infectious Diseases, Department of Medicine, University of Washington, Seattle, WA 98109, USACenter for Emerging and Re-emerging Infectious Diseases (CERID), Division of Allergy and Infectious Diseases, Department of Medicine, University of Washington, Seattle, WA 98109, USADepartment of Pharmaceutical Microbiology, Faculty of Pharmacy, University of Ibadan, Ibadan, NigeriaCenter for Emerging and Re-emerging Infectious Diseases (CERID), Division of Allergy and Infectious Diseases, Department of Medicine, University of Washington, Seattle, WA 98109, USACenter for Emerging and Re-emerging Infectious Diseases (CERID), Division of Allergy and Infectious Diseases, Department of Medicine, University of Washington, Seattle, WA 98109, USADepartment of Pharmaceutical Microbiology, Faculty of Pharmacy, University of Ibadan, Ibadan, NigeriaDepartment of Biology, University of Oregon, Eugene, OR 97403, USACenter for Emerging and Re-emerging Infectious Diseases (CERID), Division of Allergy and Infectious Diseases, Department of Medicine, University of Washington, Seattle, WA 98109, USACenter for Emerging and Re-emerging Infectious Diseases (CERID), Division of Allergy and Infectious Diseases, Department of Medicine, University of Washington, Seattle, WA 98109, USATransmission of human malaria parasites (<i>Plasmodium</i> spp.) by <i>Anopheles</i> mosquitoes is a continuous process that presents a formidable challenge for effective control of the disease. Infectious gametocytes continue to circulate in humans for up to four weeks after antimalarial drug treatment, permitting prolonged transmission to mosquitoes even after clinical cure. Almost all reported malaria cases are transmitted to humans by mosquitoes, and therefore decreasing the rate of <i>Plasmodium </i>transmission from humans to mosquitoes with novel transmission-blocking remedies would be an important complement to other interventions in reducing malaria incidence.https://www.mdpi.com/1420-3049/25/12/2773malaria<i>Plasmodium </i>spp.transmission reducing interventionsbumped kinase inhibitorscalcium-dependent protein kinase inhibitors |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Ryan Choi Samantha A. Michaels Emmanuel C. Onu Matthew A. Hulverson Aparajita Saha Morenike E. Coker Janis C. Weeks Wesley C. Van Voorhis Kayode K. Ojo |
spellingShingle |
Ryan Choi Samantha A. Michaels Emmanuel C. Onu Matthew A. Hulverson Aparajita Saha Morenike E. Coker Janis C. Weeks Wesley C. Van Voorhis Kayode K. Ojo Taming the Boys for Global Good: Contraceptive Strategy to Stop Malaria Transmission Molecules malaria <i>Plasmodium </i>spp. transmission reducing interventions bumped kinase inhibitors calcium-dependent protein kinase inhibitors |
author_facet |
Ryan Choi Samantha A. Michaels Emmanuel C. Onu Matthew A. Hulverson Aparajita Saha Morenike E. Coker Janis C. Weeks Wesley C. Van Voorhis Kayode K. Ojo |
author_sort |
Ryan Choi |
title |
Taming the Boys for Global Good: Contraceptive Strategy to Stop Malaria Transmission |
title_short |
Taming the Boys for Global Good: Contraceptive Strategy to Stop Malaria Transmission |
title_full |
Taming the Boys for Global Good: Contraceptive Strategy to Stop Malaria Transmission |
title_fullStr |
Taming the Boys for Global Good: Contraceptive Strategy to Stop Malaria Transmission |
title_full_unstemmed |
Taming the Boys for Global Good: Contraceptive Strategy to Stop Malaria Transmission |
title_sort |
taming the boys for global good: contraceptive strategy to stop malaria transmission |
publisher |
MDPI AG |
series |
Molecules |
issn |
1420-3049 |
publishDate |
2020-06-01 |
description |
Transmission of human malaria parasites (<i>Plasmodium</i> spp.) by <i>Anopheles</i> mosquitoes is a continuous process that presents a formidable challenge for effective control of the disease. Infectious gametocytes continue to circulate in humans for up to four weeks after antimalarial drug treatment, permitting prolonged transmission to mosquitoes even after clinical cure. Almost all reported malaria cases are transmitted to humans by mosquitoes, and therefore decreasing the rate of <i>Plasmodium </i>transmission from humans to mosquitoes with novel transmission-blocking remedies would be an important complement to other interventions in reducing malaria incidence. |
topic |
malaria <i>Plasmodium </i>spp. transmission reducing interventions bumped kinase inhibitors calcium-dependent protein kinase inhibitors |
url |
https://www.mdpi.com/1420-3049/25/12/2773 |
work_keys_str_mv |
AT ryanchoi tamingtheboysforglobalgoodcontraceptivestrategytostopmalariatransmission AT samanthaamichaels tamingtheboysforglobalgoodcontraceptivestrategytostopmalariatransmission AT emmanuelconu tamingtheboysforglobalgoodcontraceptivestrategytostopmalariatransmission AT matthewahulverson tamingtheboysforglobalgoodcontraceptivestrategytostopmalariatransmission AT aparajitasaha tamingtheboysforglobalgoodcontraceptivestrategytostopmalariatransmission AT morenikeecoker tamingtheboysforglobalgoodcontraceptivestrategytostopmalariatransmission AT janiscweeks tamingtheboysforglobalgoodcontraceptivestrategytostopmalariatransmission AT wesleycvanvoorhis tamingtheboysforglobalgoodcontraceptivestrategytostopmalariatransmission AT kayodekojo tamingtheboysforglobalgoodcontraceptivestrategytostopmalariatransmission |
_version_ |
1724707174711558144 |