Taming the Boys for Global Good: Contraceptive Strategy to Stop Malaria Transmission

Taming the Boys for Global Good: Contraceptive Strategy to Stop Malaria Transmission

Transmission of human malaria parasites (<i>Plasmodium</i> spp.) by <i>Anopheles</i> mosquitoes is a continuous process that presents a formidable challenge for effective control of the disease. Infectious gametocytes continue to circulate in humans for up to four weeks after...

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Main Authors: Ryan Choi, Samantha A. Michaels, Emmanuel C. Onu, Matthew A. Hulverson, Aparajita Saha, Morenike E. Coker, Janis C. Weeks, Wesley C. Van Voorhis, Kayode K. Ojo
Format: Article
Language:English
Published: MDPI AG 2020-06-01
Series:Molecules
Subjects:
malaria
<i>Plasmodium </i>spp.
transmission reducing interventions
bumped kinase inhibitors
calcium-dependent protein kinase inhibitors
Online Access:https://www.mdpi.com/1420-3049/25/12/2773
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spelling doaj-536274f939304bdbab45b7bfee39c93a2020-11-25T02:58:18ZengMDPI AGMolecules1420-30492020-06-01252773277310.3390/molecules25122773Taming the Boys for Global Good: Contraceptive Strategy to Stop Malaria TransmissionRyan Choi0Samantha A. Michaels1Emmanuel C. Onu2Matthew A. Hulverson3Aparajita Saha4Morenike E. Coker5Janis C. Weeks6Wesley C. Van Voorhis7Kayode K. Ojo8Center for Emerging and Re-emerging Infectious Diseases (CERID), Division of Allergy and Infectious Diseases, Department of Medicine, University of Washington, Seattle, WA 98109, USACenter for Emerging and Re-emerging Infectious Diseases (CERID), Division of Allergy and Infectious Diseases, Department of Medicine, University of Washington, Seattle, WA 98109, USADepartment of Pharmaceutical Microbiology, Faculty of Pharmacy, University of Ibadan, Ibadan, NigeriaCenter for Emerging and Re-emerging Infectious Diseases (CERID), Division of Allergy and Infectious Diseases, Department of Medicine, University of Washington, Seattle, WA 98109, USACenter for Emerging and Re-emerging Infectious Diseases (CERID), Division of Allergy and Infectious Diseases, Department of Medicine, University of Washington, Seattle, WA 98109, USADepartment of Pharmaceutical Microbiology, Faculty of Pharmacy, University of Ibadan, Ibadan, NigeriaDepartment of Biology, University of Oregon, Eugene, OR 97403, USACenter for Emerging and Re-emerging Infectious Diseases (CERID), Division of Allergy and Infectious Diseases, Department of Medicine, University of Washington, Seattle, WA 98109, USACenter for Emerging and Re-emerging Infectious Diseases (CERID), Division of Allergy and Infectious Diseases, Department of Medicine, University of Washington, Seattle, WA 98109, USATransmission of human malaria parasites (<i>Plasmodium</i> spp.) by <i>Anopheles</i> mosquitoes is a continuous process that presents a formidable challenge for effective control of the disease. Infectious gametocytes continue to circulate in humans for up to four weeks after antimalarial drug treatment, permitting prolonged transmission to mosquitoes even after clinical cure. Almost all reported malaria cases are transmitted to humans by mosquitoes, and therefore decreasing the rate of <i>Plasmodium </i>transmission from humans to mosquitoes with novel transmission-blocking remedies would be an important complement to other interventions in reducing malaria incidence.https://www.mdpi.com/1420-3049/25/12/2773malaria<i>Plasmodium </i>spp.transmission reducing interventionsbumped kinase inhibitorscalcium-dependent protein kinase inhibitors
collection DOAJ
language English
format Article
sources DOAJ
author Ryan Choi
Samantha A. Michaels
Emmanuel C. Onu
Matthew A. Hulverson
Aparajita Saha
Morenike E. Coker
Janis C. Weeks
Wesley C. Van Voorhis
Kayode K. Ojo
spellingShingle Ryan Choi
Samantha A. Michaels
Emmanuel C. Onu
Matthew A. Hulverson
Aparajita Saha
Morenike E. Coker
Janis C. Weeks
Wesley C. Van Voorhis
Kayode K. Ojo
Taming the Boys for Global Good: Contraceptive Strategy to Stop Malaria Transmission
Molecules
malaria
<i>Plasmodium </i>spp.
transmission reducing interventions
bumped kinase inhibitors
calcium-dependent protein kinase inhibitors
author_facet Ryan Choi
Samantha A. Michaels
Emmanuel C. Onu
Matthew A. Hulverson
Aparajita Saha
Morenike E. Coker
Janis C. Weeks
Wesley C. Van Voorhis
Kayode K. Ojo
author_sort Ryan Choi
title Taming the Boys for Global Good: Contraceptive Strategy to Stop Malaria Transmission
title_short Taming the Boys for Global Good: Contraceptive Strategy to Stop Malaria Transmission
title_full Taming the Boys for Global Good: Contraceptive Strategy to Stop Malaria Transmission
title_fullStr Taming the Boys for Global Good: Contraceptive Strategy to Stop Malaria Transmission
title_full_unstemmed Taming the Boys for Global Good: Contraceptive Strategy to Stop Malaria Transmission
title_sort taming the boys for global good: contraceptive strategy to stop malaria transmission
publisher MDPI AG
series Molecules
issn 1420-3049
publishDate 2020-06-01
description Transmission of human malaria parasites (<i>Plasmodium</i> spp.) by <i>Anopheles</i> mosquitoes is a continuous process that presents a formidable challenge for effective control of the disease. Infectious gametocytes continue to circulate in humans for up to four weeks after antimalarial drug treatment, permitting prolonged transmission to mosquitoes even after clinical cure. Almost all reported malaria cases are transmitted to humans by mosquitoes, and therefore decreasing the rate of <i>Plasmodium </i>transmission from humans to mosquitoes with novel transmission-blocking remedies would be an important complement to other interventions in reducing malaria incidence.
topic malaria
<i>Plasmodium </i>spp.
transmission reducing interventions
bumped kinase inhibitors
calcium-dependent protein kinase inhibitors
url https://www.mdpi.com/1420-3049/25/12/2773
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