Cardiac Specific Knockout of p53 Decreases ER Stress-Induced Mitochondrial Damage

Cardiac Specific Knockout of p53 Decreases ER Stress-Induced Mitochondrial Damage

Endoplasmic reticulum (ER) stress contributes to cardiovascular disease including heart failure. Interactions between the ER and mitochondria during ER stress can impair the mitochondrial respiratory chain and increase cell injury. p53 is a tumor suppressor protein that regulates apoptosis. p53 cont...

Full description

Bibliographic Details
Main Authors: Qun Chen, Jeremy Thompson, Ying Hu, Anindita Das, Edward J. Lesnefsky
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-02-01
Series:Frontiers in Cardiovascular Medicine
Subjects:
mitochondria
complex I
thapsigargin
apoptosis
pyruvate dehydrogenase
Online Access:https://www.frontiersin.org/article/10.3389/fcvm.2019.00010/full

Internet

https://www.frontiersin.org/article/10.3389/fcvm.2019.00010/full

Similar Items