Value of Plasmatic Membrane Attack Complex as a Marker of Severity in Acute Kidney Injury
The aim of this study was to determine if complement pathway is activated in AKI; for this purpose, we measured, through ELISA sandwich, the terminal lytic fraction of the complement system, called membrane attack complex (C5b-C9), in AKI patients compared with patients with similar clinical conditi...
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doaj-53675810bb7145c7a2a1b08cd0d65ec92020-11-24T20:41:20ZengHindawi LimitedBioMed Research International2314-61332314-61412014-01-01201410.1155/2014/361065361065Value of Plasmatic Membrane Attack Complex as a Marker of Severity in Acute Kidney InjuryEva Rodríguez0Marta Riera1Clara Barrios2Julio Pascual3Departamento de Nefrología, Hospital del Mar, Passeig Marítim 25-29, 08003 Barcelona, SpainDepartamento de Nefrología, Hospital del Mar, Passeig Marítim 25-29, 08003 Barcelona, SpainDepartamento de Nefrología, Hospital del Mar, Passeig Marítim 25-29, 08003 Barcelona, SpainDepartamento de Nefrología, Hospital del Mar, Passeig Marítim 25-29, 08003 Barcelona, SpainThe aim of this study was to determine if complement pathway is activated in AKI; for this purpose, we measured, through ELISA sandwich, the terminal lytic fraction of the complement system, called membrane attack complex (C5b-C9), in AKI patients compared with patients with similar clinical conditions but normal renal function. Our data showed that complement system is activated in AKI. Plasmatic MAC concentrations were significantly higher in AKI patients than in those with normal renal function; this difference is maintained independently of the AKI etiology and is proportional to the severity of AKI, measured by ADQI classification. In addition, we found that plasmatic MAC concentrations were significantly higher in patients who did not recover renal function at time of hospitalization discharge, in patients who died during the acute process, and in patients who need renal replacement therapy during hospitalization, but in this last group, the differences did not reach statistical significance. In conclusion, plasmatic MAC concentration seems valuable as a marker of AKI severity.http://dx.doi.org/10.1155/2014/361065 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Eva Rodríguez Marta Riera Clara Barrios Julio Pascual |
spellingShingle |
Eva Rodríguez Marta Riera Clara Barrios Julio Pascual Value of Plasmatic Membrane Attack Complex as a Marker of Severity in Acute Kidney Injury BioMed Research International |
author_facet |
Eva Rodríguez Marta Riera Clara Barrios Julio Pascual |
author_sort |
Eva Rodríguez |
title |
Value of Plasmatic Membrane Attack Complex as a Marker of Severity in Acute Kidney Injury |
title_short |
Value of Plasmatic Membrane Attack Complex as a Marker of Severity in Acute Kidney Injury |
title_full |
Value of Plasmatic Membrane Attack Complex as a Marker of Severity in Acute Kidney Injury |
title_fullStr |
Value of Plasmatic Membrane Attack Complex as a Marker of Severity in Acute Kidney Injury |
title_full_unstemmed |
Value of Plasmatic Membrane Attack Complex as a Marker of Severity in Acute Kidney Injury |
title_sort |
value of plasmatic membrane attack complex as a marker of severity in acute kidney injury |
publisher |
Hindawi Limited |
series |
BioMed Research International |
issn |
2314-6133 2314-6141 |
publishDate |
2014-01-01 |
description |
The aim of this study was to determine if complement pathway is activated in AKI; for this purpose, we measured, through ELISA sandwich, the terminal lytic fraction of the complement system, called membrane attack complex (C5b-C9), in AKI patients compared with patients with similar clinical conditions but normal renal function. Our data showed that complement system is activated in AKI. Plasmatic MAC concentrations were significantly higher in AKI patients than in those with normal renal function; this difference is maintained independently of the AKI etiology and is proportional to the severity of AKI, measured by ADQI classification. In addition, we found that plasmatic MAC concentrations were significantly higher in patients who did not recover renal function at time of hospitalization discharge, in patients who died during the acute process, and in patients who need renal replacement therapy during hospitalization, but in this last group, the differences did not reach statistical significance. In conclusion, plasmatic MAC concentration seems valuable as a marker of AKI severity. |
url |
http://dx.doi.org/10.1155/2014/361065 |
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