7-Iodo-1H-indole-3-carbonitrile

7-Iodo-1H-indole-3-carbonitrile

The title compound was prepared by a Friedel–Crafts acylation-oxime synthesis-decarboxylation/dehydration sequence starting from commercially available 7-iodoindole with 2-(7-iodo-1H-indol-3-yl)-2-oxoacetic acid as isolated intermediate. The structural identity of the title compound was proven by...

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Bibliographic Details
Main Authors: Rosanna Meine, Hannes Falke, Jana Kötz, Sandra I. Schweda, Conrad Kunick
Format: Article
Language:English
Published: MDPI AG 2015-10-01
Series:Molbank
Subjects:
decarboxylation, dehydration, indole, nitrile, oxime, protein kinase inhibitor
Online Access:http://www.mdpi.com/1422-8599/2015/4/M869
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spelling doaj-536b6dc79ad64e9fbcc59ef02c6a0b972020-11-24T21:05:15ZengMDPI AGMolbank1422-85992015-10-0120154M86910.3390/M869M8697-Iodo-1H-indole-3-carbonitrileRosanna Meine0Hannes Falke1Jana Kötz2Sandra I. Schweda3Conrad Kunick4Institut für Medizinische und Pharmazeutische Chemie, Technische Universität Braunschweig, Beethovenstraße 55, 38106 Braunschweig, GermanyInstitut für Medizinische und Pharmazeutische Chemie, Technische Universität Braunschweig, Beethovenstraße 55, 38106 Braunschweig, GermanyInstitut für Medizinische und Pharmazeutische Chemie, Technische Universität Braunschweig, Beethovenstraße 55, 38106 Braunschweig, GermanyInstitut für Medizinische und Pharmazeutische Chemie, Technische Universität Braunschweig, Beethovenstraße 55, 38106 Braunschweig, GermanyInstitut für Medizinische und Pharmazeutische Chemie, Technische Universität Braunschweig, Beethovenstraße 55, 38106 Braunschweig, GermanyThe title compound was prepared by a Friedel–Crafts acylation-oxime synthesis-decarboxylation/dehydration sequence starting from commercially available 7-iodoindole with 2-(7-iodo-1H-indol-3-yl)-2-oxoacetic acid as isolated intermediate. The structural identity of the title compound was proven by elemental analysis and spectroscopic methods (IR, NMR, EI-MS), and purity was assessed by two independent HPLC methods.http://www.mdpi.com/1422-8599/2015/4/M869decarboxylation, dehydration, indole, nitrile, oxime, protein kinase inhibitor
collection DOAJ
language English
format Article
sources DOAJ
author Rosanna Meine
Hannes Falke
Jana Kötz
Sandra I. Schweda
Conrad Kunick
spellingShingle Rosanna Meine
Hannes Falke
Jana Kötz
Sandra I. Schweda
Conrad Kunick
7-Iodo-1H-indole-3-carbonitrile
Molbank
decarboxylation, dehydration, indole, nitrile, oxime, protein kinase inhibitor
author_facet Rosanna Meine
Hannes Falke
Jana Kötz
Sandra I. Schweda
Conrad Kunick
author_sort Rosanna Meine
title 7-Iodo-1H-indole-3-carbonitrile
title_short 7-Iodo-1H-indole-3-carbonitrile
title_full 7-Iodo-1H-indole-3-carbonitrile
title_fullStr 7-Iodo-1H-indole-3-carbonitrile
title_full_unstemmed 7-Iodo-1H-indole-3-carbonitrile
title_sort 7-iodo-1h-indole-3-carbonitrile
publisher MDPI AG
series Molbank
issn 1422-8599
publishDate 2015-10-01
description The title compound was prepared by a Friedel–Crafts acylation-oxime synthesis-decarboxylation/dehydration sequence starting from commercially available 7-iodoindole with 2-(7-iodo-1H-indol-3-yl)-2-oxoacetic acid as isolated intermediate. The structural identity of the title compound was proven by elemental analysis and spectroscopic methods (IR, NMR, EI-MS), and purity was assessed by two independent HPLC methods.
topic decarboxylation, dehydration, indole, nitrile, oxime, protein kinase inhibitor
url http://www.mdpi.com/1422-8599/2015/4/M869
work_keys_str_mv AT rosannameine 7iodo1hindole3carbonitrile
AT hannesfalke 7iodo1hindole3carbonitrile
AT janakotz 7iodo1hindole3carbonitrile
AT sandraischweda 7iodo1hindole3carbonitrile
AT conradkunick 7iodo1hindole3carbonitrile
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