7-Iodo-1H-indole-3-carbonitrile
The title compound was prepared by a Friedel–Crafts acylation-oxime synthesis-decarboxylation/dehydration sequence starting from commercially available 7-iodoindole with 2-(7-iodo-1H-indol-3-yl)-2-oxoacetic acid as isolated intermediate. The structural identity of the title compound was proven by...
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Online Access: | http://www.mdpi.com/1422-8599/2015/4/M869 |
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doaj-536b6dc79ad64e9fbcc59ef02c6a0b972020-11-24T21:05:15ZengMDPI AGMolbank1422-85992015-10-0120154M86910.3390/M869M8697-Iodo-1H-indole-3-carbonitrileRosanna Meine0Hannes Falke1Jana Kötz2Sandra I. Schweda3Conrad Kunick4Institut für Medizinische und Pharmazeutische Chemie, Technische Universität Braunschweig, Beethovenstraße 55, 38106 Braunschweig, GermanyInstitut für Medizinische und Pharmazeutische Chemie, Technische Universität Braunschweig, Beethovenstraße 55, 38106 Braunschweig, GermanyInstitut für Medizinische und Pharmazeutische Chemie, Technische Universität Braunschweig, Beethovenstraße 55, 38106 Braunschweig, GermanyInstitut für Medizinische und Pharmazeutische Chemie, Technische Universität Braunschweig, Beethovenstraße 55, 38106 Braunschweig, GermanyInstitut für Medizinische und Pharmazeutische Chemie, Technische Universität Braunschweig, Beethovenstraße 55, 38106 Braunschweig, GermanyThe title compound was prepared by a Friedel–Crafts acylation-oxime synthesis-decarboxylation/dehydration sequence starting from commercially available 7-iodoindole with 2-(7-iodo-1H-indol-3-yl)-2-oxoacetic acid as isolated intermediate. The structural identity of the title compound was proven by elemental analysis and spectroscopic methods (IR, NMR, EI-MS), and purity was assessed by two independent HPLC methods.http://www.mdpi.com/1422-8599/2015/4/M869decarboxylation, dehydration, indole, nitrile, oxime, protein kinase inhibitor |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Rosanna Meine Hannes Falke Jana Kötz Sandra I. Schweda Conrad Kunick |
spellingShingle |
Rosanna Meine Hannes Falke Jana Kötz Sandra I. Schweda Conrad Kunick 7-Iodo-1H-indole-3-carbonitrile Molbank decarboxylation, dehydration, indole, nitrile, oxime, protein kinase inhibitor |
author_facet |
Rosanna Meine Hannes Falke Jana Kötz Sandra I. Schweda Conrad Kunick |
author_sort |
Rosanna Meine |
title |
7-Iodo-1H-indole-3-carbonitrile |
title_short |
7-Iodo-1H-indole-3-carbonitrile |
title_full |
7-Iodo-1H-indole-3-carbonitrile |
title_fullStr |
7-Iodo-1H-indole-3-carbonitrile |
title_full_unstemmed |
7-Iodo-1H-indole-3-carbonitrile |
title_sort |
7-iodo-1h-indole-3-carbonitrile |
publisher |
MDPI AG |
series |
Molbank |
issn |
1422-8599 |
publishDate |
2015-10-01 |
description |
The title compound was prepared by a Friedel–Crafts acylation-oxime synthesis-decarboxylation/dehydration sequence starting from commercially available 7-iodoindole with 2-(7-iodo-1H-indol-3-yl)-2-oxoacetic acid as isolated intermediate. The structural identity of the title compound was proven by elemental analysis and spectroscopic methods (IR, NMR, EI-MS), and purity was assessed by two independent HPLC methods. |
topic |
decarboxylation, dehydration, indole, nitrile, oxime, protein kinase inhibitor |
url |
http://www.mdpi.com/1422-8599/2015/4/M869 |
work_keys_str_mv |
AT rosannameine 7iodo1hindole3carbonitrile AT hannesfalke 7iodo1hindole3carbonitrile AT janakotz 7iodo1hindole3carbonitrile AT sandraischweda 7iodo1hindole3carbonitrile AT conradkunick 7iodo1hindole3carbonitrile |
_version_ |
1716769427877265408 |