Respiratory panic disorder subtype and sensitivity to the carbon dioxide challenge test
The aim of the present study was to verify the sensitivity to the carbon dioxide (CO2) challenge test of panic disorder (PD) patients with respiratory and nonrespiratory subtypes of the disorder. Our hypothesis is that the respiratory subtype is more sensitive to 35% CO2. Twenty-seven PD subjects wi...
Main Authors: | , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Associação Brasileira de Divulgação Científica
2002-07-01
|
Series: | Brazilian Journal of Medical and Biological Research |
Subjects: | |
Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2002000700004 |
id |
doaj-5383d40b636046a3bfe85075f602341c |
---|---|
record_format |
Article |
spelling |
doaj-5383d40b636046a3bfe85075f602341c2020-11-25T01:59:23ZengAssociação Brasileira de Divulgação CientíficaBrazilian Journal of Medical and Biological Research0100-879X1414-431X2002-07-0135778378810.1590/S0100-879X2002000700004Respiratory panic disorder subtype and sensitivity to the carbon dioxide challenge testA.M. ValençaA.E. NardiI. NascimentoW.A. ZinM. VersianiThe aim of the present study was to verify the sensitivity to the carbon dioxide (CO2) challenge test of panic disorder (PD) patients with respiratory and nonrespiratory subtypes of the disorder. Our hypothesis is that the respiratory subtype is more sensitive to 35% CO2. Twenty-seven PD subjects with or without agoraphobia were classified into respiratory and nonrespiratory subtypes on the basis of the presence of respiratory symptoms during their panic attacks. The tests were carried out in a double-blind manner using two mixtures: 1) 35% CO2 and 65% O2, and 2) 100% atmospheric compressed air, 20 min apart. The tests were repeated after 2 weeks during which the participants in the study did not receive any psychotropic drugs. At least 15 of 16 (93.7%) respiratory PD subtype patients and 5 of 11 (43.4%) nonrespiratory PD patients had a panic attack during one of two CO2 challenges (P = 0.009, Fisher exact test). Respiratory PD subtype patients were more sensitive to the CO2 challenge test. There was agreement between the severity of PD measured by the Clinical Global Impression (CGI) Scale and the subtype of PD. Higher CGI scores in the respiratory PD subtype could reflect a greater sensitivity to the CO2 challenge due to a greater severity of PD. Carbon dioxide challenges in PD may define PD subtypes and their underlying mechanisms.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2002000700004CO2AnxietyBreathingRespiration |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
A.M. Valença A.E. Nardi I. Nascimento W.A. Zin M. Versiani |
spellingShingle |
A.M. Valença A.E. Nardi I. Nascimento W.A. Zin M. Versiani Respiratory panic disorder subtype and sensitivity to the carbon dioxide challenge test Brazilian Journal of Medical and Biological Research CO2 Anxiety Breathing Respiration |
author_facet |
A.M. Valença A.E. Nardi I. Nascimento W.A. Zin M. Versiani |
author_sort |
A.M. Valença |
title |
Respiratory panic disorder subtype and sensitivity to the carbon dioxide challenge test |
title_short |
Respiratory panic disorder subtype and sensitivity to the carbon dioxide challenge test |
title_full |
Respiratory panic disorder subtype and sensitivity to the carbon dioxide challenge test |
title_fullStr |
Respiratory panic disorder subtype and sensitivity to the carbon dioxide challenge test |
title_full_unstemmed |
Respiratory panic disorder subtype and sensitivity to the carbon dioxide challenge test |
title_sort |
respiratory panic disorder subtype and sensitivity to the carbon dioxide challenge test |
publisher |
Associação Brasileira de Divulgação Científica |
series |
Brazilian Journal of Medical and Biological Research |
issn |
0100-879X 1414-431X |
publishDate |
2002-07-01 |
description |
The aim of the present study was to verify the sensitivity to the carbon dioxide (CO2) challenge test of panic disorder (PD) patients with respiratory and nonrespiratory subtypes of the disorder. Our hypothesis is that the respiratory subtype is more sensitive to 35% CO2. Twenty-seven PD subjects with or without agoraphobia were classified into respiratory and nonrespiratory subtypes on the basis of the presence of respiratory symptoms during their panic attacks. The tests were carried out in a double-blind manner using two mixtures: 1) 35% CO2 and 65% O2, and 2) 100% atmospheric compressed air, 20 min apart. The tests were repeated after 2 weeks during which the participants in the study did not receive any psychotropic drugs. At least 15 of 16 (93.7%) respiratory PD subtype patients and 5 of 11 (43.4%) nonrespiratory PD patients had a panic attack during one of two CO2 challenges (P = 0.009, Fisher exact test). Respiratory PD subtype patients were more sensitive to the CO2 challenge test. There was agreement between the severity of PD measured by the Clinical Global Impression (CGI) Scale and the subtype of PD. Higher CGI scores in the respiratory PD subtype could reflect a greater sensitivity to the CO2 challenge due to a greater severity of PD. Carbon dioxide challenges in PD may define PD subtypes and their underlying mechanisms. |
topic |
CO2 Anxiety Breathing Respiration |
url |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2002000700004 |
work_keys_str_mv |
AT amvalenca respiratorypanicdisordersubtypeandsensitivitytothecarbondioxidechallengetest AT aenardi respiratorypanicdisordersubtypeandsensitivitytothecarbondioxidechallengetest AT inascimento respiratorypanicdisordersubtypeandsensitivitytothecarbondioxidechallengetest AT wazin respiratorypanicdisordersubtypeandsensitivitytothecarbondioxidechallengetest AT mversiani respiratorypanicdisordersubtypeandsensitivitytothecarbondioxidechallengetest |
_version_ |
1724964757216165888 |