A relation of serum homocysteine, uric acid and C-reactive protein level in patients with acute myocardial infarction
Aim To determine the relationship of homocysteine (HCY), uric acid (UA) and C-reactive protein (CRP) in serum of patients with acute myocardial infarction (AMI) prior to application of percutaneous coronary intervention (PCI) and their level of correlation in serum of patients with normal and elevat...
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Medical Association of Zenica-Doboj Canton
2018-08-01
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doaj-5399bdacf8e44774a1874c19bd2d396d2020-11-24T21:51:20ZengMedical Association of Zenica-Doboj CantonMedicinski Glasnik1840-01321840-24452018-08-0115210110810.17392/956-18A relation of serum homocysteine, uric acid and C-reactive protein level in patients with acute myocardial infarctionMarijana Marković Boras0Adlija Čaušević1Ivica Brizić2Ivanka Mikulić3Marina Vasilj4Nevenka Jelić-Knezović5Department of Laboratory Medicine, University Clinical Hospital Mostar, MostarDepartment of Biochemistry and Clinical Analysis, Faculty of Pharmacy, University of Sarajevo, SarajevoDepartment of Cardiology, University Clinical Hospital Mostar, MostarDepartment of Laboratory Medicine, University Clinical Hospital Mostar, MostarDepartment of Laboratory Medicine, University Clinical Hospital Mostar, MostarSchool of Medicine, University of Mostar, Mostar; Bosnia and HerzegovinaAim To determine the relationship of homocysteine (HCY), uric acid (UA) and C-reactive protein (CRP) in serum of patients with acute myocardial infarction (AMI) prior to application of percutaneous coronary intervention (PCI) and their level of correlation in serum of patients with normal and elevated CRP (predictor of worse cardiovascular outcomes). Methods The study involved 85 patients with diagnosed AMI. Before the PCI, venous blood samples were taken into the vacuum test tubes. The analysis of HCY, UA, inflammatory markers CRP and neutrophil to lymphocyte ratio (NLR) as well as lipoprotein status were performed on a different type of analysers and according to accepted protocols of the International Federation of Clinical Chemistry and Laboratory Medicine (IFCC). Results Elevated level of both HCY and UA in AMI patients as well as a positive correlation between HCY and UA level was observed. Classification of patients on the basis of mean UA concentration showed significant difference at the level of HCY concentration (p=0.022). Conclusion Since HCY and UA participate in the atherosclerotic process and their metabolism, as well as the effects on the cardiovascular system show significant overlaps, their serum level should be analysed synchronously with the level of CRP and NLR (indicators of significant inflammatory process in vessels). Considering a potential link between all parameters observed, further research involving a greater number of patients and including the post treatment effects should be conducted.http://ljkzedo.ba/wordpress/wp-content/uploads/2018/07/08-Markovic-Boras-956-A.pdfST elevation myocardial infarctioninflammationatherosclerosisoxidative stress |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Marijana Marković Boras Adlija Čaušević Ivica Brizić Ivanka Mikulić Marina Vasilj Nevenka Jelić-Knezović |
spellingShingle |
Marijana Marković Boras Adlija Čaušević Ivica Brizić Ivanka Mikulić Marina Vasilj Nevenka Jelić-Knezović A relation of serum homocysteine, uric acid and C-reactive protein level in patients with acute myocardial infarction Medicinski Glasnik ST elevation myocardial infarction inflammation atherosclerosis oxidative stress |
author_facet |
Marijana Marković Boras Adlija Čaušević Ivica Brizić Ivanka Mikulić Marina Vasilj Nevenka Jelić-Knezović |
author_sort |
Marijana Marković Boras |
title |
A relation of serum homocysteine, uric acid and C-reactive protein level in patients with acute myocardial infarction |
title_short |
A relation of serum homocysteine, uric acid and C-reactive protein level in patients with acute myocardial infarction |
title_full |
A relation of serum homocysteine, uric acid and C-reactive protein level in patients with acute myocardial infarction |
title_fullStr |
A relation of serum homocysteine, uric acid and C-reactive protein level in patients with acute myocardial infarction |
title_full_unstemmed |
A relation of serum homocysteine, uric acid and C-reactive protein level in patients with acute myocardial infarction |
title_sort |
relation of serum homocysteine, uric acid and c-reactive protein level in patients with acute myocardial infarction |
publisher |
Medical Association of Zenica-Doboj Canton |
series |
Medicinski Glasnik |
issn |
1840-0132 1840-2445 |
publishDate |
2018-08-01 |
description |
Aim To determine the relationship of homocysteine (HCY), uric acid (UA) and C-reactive protein (CRP) in serum of patients with acute myocardial infarction (AMI) prior to application of percutaneous coronary intervention (PCI) and their level of correlation in serum of patients with normal and elevated CRP (predictor of worse cardiovascular outcomes).
Methods The study involved 85 patients with diagnosed AMI. Before the PCI, venous blood samples were taken into the vacuum test tubes. The analysis of HCY, UA, inflammatory markers CRP and neutrophil to lymphocyte ratio (NLR) as well as lipoprotein status were performed on a different type of analysers and according to accepted protocols of the International Federation of Clinical Chemistry and Laboratory Medicine (IFCC).
Results Elevated level of both HCY and UA in AMI patients as well as a positive correlation between HCY and UA level was observed. Classification of patients on the basis of mean UA concentration showed significant difference at the level of HCY concentration (p=0.022).
Conclusion Since HCY and UA participate in the atherosclerotic process and their metabolism, as well as the effects on the cardiovascular system show significant overlaps, their serum level should be analysed synchronously with the level of CRP and NLR (indicators of significant inflammatory process in vessels). Considering a potential link between all parameters observed, further research involving a greater number of patients and including the post treatment effects should be conducted. |
topic |
ST elevation myocardial infarction inflammation atherosclerosis oxidative stress |
url |
http://ljkzedo.ba/wordpress/wp-content/uploads/2018/07/08-Markovic-Boras-956-A.pdf |
work_keys_str_mv |
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