Physical, Psychological, and Social Factors Associated with Exacerbation-Related Hospitalization in Patients with COPD
Background and objective: Exacerbation(s) of chronic obstructive pulmonary disease (eCOPD) entail important events describing an acute deterioration of respiratory symptoms. Changes in medication and/or hospitalization are needed to gain control over the event. However, an exacerbation leading to ho...
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doaj-539c5dcc75064e8085e3e69b08c234202020-11-25T00:36:54ZengMDPI AGJournal of Clinical Medicine2077-03832020-02-019363610.3390/jcm9030636jcm9030636Physical, Psychological, and Social Factors Associated with Exacerbation-Related Hospitalization in Patients with COPDMieke R.C. Crutsen0Spencer J. Keene1Daisy J.A. Janssen Nienke Nakken2Miriam T. Groenen3Sander M.J. van Kuijk4Frits M.E. Franssen5Emiel F.M. Wouters6Martijn A. Spruit7Department of pulmonary functioning, Maastricht University Medical Centre (MUMC+), 6229 HX Maastricht, The NetherlandsDepartment of Research and Development, CIRO+, 6058 NM Horn, The NetherlandsDepartment of Research and Development, CIRO+, 6058 NM Horn, The NetherlandsDepartment of Research and Development, CIRO+, 6058 NM Horn, The NetherlandsDepartment of Clinical Epidemiology and Medical Technology Assessment, Maastricht University Medical Centre (MUMC+), 6229 HX Maastricht, The NetherlandsDepartment of Research and Development, CIRO+, 6058 NM Horn, The NetherlandsDepartment of Research and Development, CIRO+, 6058 NM Horn, The NetherlandsDepartment of Research and Development, CIRO+, 6058 NM Horn, The NetherlandsBackground and objective: Exacerbation(s) of chronic obstructive pulmonary disease (eCOPD) entail important events describing an acute deterioration of respiratory symptoms. Changes in medication and/or hospitalization are needed to gain control over the event. However, an exacerbation leading to hospitalization is associated with a worse prognosis for the patient. The objective of this study is to explore factors that could predict the probability of an eCOPD-related hospitalization. Methods: Data from 128 patients with COPD included in a prospective, longitudinal study were used. At baseline, physical, emotional, and social status of the patients were assessed. Moreover, hospital admission during a one year follow-up was captured. Different models were made based on univariate analysis, literature, and practice. These models were combined to come to one final overall prediction model. Results: During follow-up, 31 (24.2%) participants were admitted for eCOPD. The overall model contained six significant variables: currently smoking (OR = 3.93), forced vital capacity (FVC; OR = 0.97), timed-up-and-go time (TUG-time) (OR = 14.16), knowledge (COPD knowledge questionnaire, percentage correctly answered questions (CIROPD<sub>%correct</sub>)) (<60% (OR = 1.00); 60%−75%: (OR = 0.30); >75%: (OR = 1.94), eCOPD history (OR = 9.98), and care dependency scale (CDS) total score (OR = 1.12). This model was well calibrated (goodness-of-fit test: <i>p</i> = 0.91) and correctly classified 79.7% of the patients. Conclusion: A combination of TUG-time, eCOPD-related admission(s) prior to baseline, currently smoking, FVC, CDS total score, and CIROPD<sub>%correct</sub> allows clinicians to predict the probability of an eCOPD-related hospitalization.https://www.mdpi.com/2077-0383/9/3/636chronic obstructive pulmonary diseasehospitalizationdisease progressionprognosispredictors |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Mieke R.C. Crutsen Spencer J. Keene Daisy J.A. Janssen Nienke Nakken Miriam T. Groenen Sander M.J. van Kuijk Frits M.E. Franssen Emiel F.M. Wouters Martijn A. Spruit |
spellingShingle |
Mieke R.C. Crutsen Spencer J. Keene Daisy J.A. Janssen Nienke Nakken Miriam T. Groenen Sander M.J. van Kuijk Frits M.E. Franssen Emiel F.M. Wouters Martijn A. Spruit Physical, Psychological, and Social Factors Associated with Exacerbation-Related Hospitalization in Patients with COPD Journal of Clinical Medicine chronic obstructive pulmonary disease hospitalization disease progression prognosis predictors |
author_facet |
Mieke R.C. Crutsen Spencer J. Keene Daisy J.A. Janssen Nienke Nakken Miriam T. Groenen Sander M.J. van Kuijk Frits M.E. Franssen Emiel F.M. Wouters Martijn A. Spruit |
author_sort |
Mieke R.C. Crutsen |
title |
Physical, Psychological, and Social Factors Associated with Exacerbation-Related Hospitalization in Patients with COPD |
title_short |
Physical, Psychological, and Social Factors Associated with Exacerbation-Related Hospitalization in Patients with COPD |
title_full |
Physical, Psychological, and Social Factors Associated with Exacerbation-Related Hospitalization in Patients with COPD |
title_fullStr |
Physical, Psychological, and Social Factors Associated with Exacerbation-Related Hospitalization in Patients with COPD |
title_full_unstemmed |
Physical, Psychological, and Social Factors Associated with Exacerbation-Related Hospitalization in Patients with COPD |
title_sort |
physical, psychological, and social factors associated with exacerbation-related hospitalization in patients with copd |
publisher |
MDPI AG |
series |
Journal of Clinical Medicine |
issn |
2077-0383 |
publishDate |
2020-02-01 |
description |
Background and objective: Exacerbation(s) of chronic obstructive pulmonary disease (eCOPD) entail important events describing an acute deterioration of respiratory symptoms. Changes in medication and/or hospitalization are needed to gain control over the event. However, an exacerbation leading to hospitalization is associated with a worse prognosis for the patient. The objective of this study is to explore factors that could predict the probability of an eCOPD-related hospitalization. Methods: Data from 128 patients with COPD included in a prospective, longitudinal study were used. At baseline, physical, emotional, and social status of the patients were assessed. Moreover, hospital admission during a one year follow-up was captured. Different models were made based on univariate analysis, literature, and practice. These models were combined to come to one final overall prediction model. Results: During follow-up, 31 (24.2%) participants were admitted for eCOPD. The overall model contained six significant variables: currently smoking (OR = 3.93), forced vital capacity (FVC; OR = 0.97), timed-up-and-go time (TUG-time) (OR = 14.16), knowledge (COPD knowledge questionnaire, percentage correctly answered questions (CIROPD<sub>%correct</sub>)) (<60% (OR = 1.00); 60%−75%: (OR = 0.30); >75%: (OR = 1.94), eCOPD history (OR = 9.98), and care dependency scale (CDS) total score (OR = 1.12). This model was well calibrated (goodness-of-fit test: <i>p</i> = 0.91) and correctly classified 79.7% of the patients. Conclusion: A combination of TUG-time, eCOPD-related admission(s) prior to baseline, currently smoking, FVC, CDS total score, and CIROPD<sub>%correct</sub> allows clinicians to predict the probability of an eCOPD-related hospitalization. |
topic |
chronic obstructive pulmonary disease hospitalization disease progression prognosis predictors |
url |
https://www.mdpi.com/2077-0383/9/3/636 |
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