Dopamine D2 Receptor-Mediated Regulation of Pancreatic β Cell Mass

Dopamine D2 Receptor-Mediated Regulation of Pancreatic β Cell Mass

Understanding the molecular mechanisms that regulate β cell mass and proliferation is important for the treatment of diabetes. Here, we identified domperidone (DPD), a dopamine D2 receptor (DRD2) antagonist that enhances β cell mass. Over time, islet β cell loss occurs in dissociation cultures, and...

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Bibliographic Details
Main Authors: Daisuke Sakano, Sungik Choi, Masateru Kataoka, Nobuaki Shiraki, Motonari Uesugi, Kazuhiko Kume, Shoen Kume
Format: Article
Language:English
Published: Elsevier 2016-07-01
Series:Stem Cell Reports
Subjects:
pancreas
insulin
proliferation
apoptosis
dedifferentiation
diabetes
Online Access:http://www.sciencedirect.com/science/article/pii/S2213671116300704

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