Formal total syntheses of classic natural product target molecules via palladium-catalyzed enantioselective alkylation

Formal total syntheses of classic natural product target molecules via palladium-catalyzed enantioselective alkylation

Pd-catalyzed enantioselective alkylation in conjunction with further synthetic elaboration enables the formal total syntheses of a number of “classic” natural product target molecules. This publication highlights recent methods for setting quaternary and tetrasubstituted tertiary carbon stereocenter...

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Bibliographic Details
Main Authors: Yiyang Liu, Marc Liniger, Ryan M. McFadden, Jenny L. Roizen, Jacquie Malette, Corey M. Reeves, Douglas C. Behenna, Masaki Seto, Jimin Kim, Justin T. Mohr, Scott C. Virgil, Brian M. Stoltz
Format: Article
Language:English
Published: Beilstein-Institut 2014-10-01
Series:Beilstein Journal of Organic Chemistry
Subjects:
enantioselective alkylation
natural products
palladium
Online Access:https://doi.org/10.3762/bjoc.10.261
Description
Summary:Pd-catalyzed enantioselective alkylation in conjunction with further synthetic elaboration enables the formal total syntheses of a number of “classic” natural product target molecules. This publication highlights recent methods for setting quaternary and tetrasubstituted tertiary carbon stereocenters to address the synthetic hurdles encountered over many decades across multiple compound classes spanning carbohydrate derivatives, terpenes, and alkaloids. These enantioselective methods will impact both academic and industrial settings, where the synthesis of stereogenic quaternary carbons is a continuing challenge.
ISSN:1860-5397

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