Protein Expressions of the Small GTPase Rho Proteins in Pterygial Tissue and Leukocytes of Patients with Pterygium

Pterygium is a benign fibrovascular proliferation that develops from the conjunctiva and invades the cornea. The etiology of this disorder remains unclear. Current treatment of pterygium is surgical. The postoperative recurrence rate of pterygium is reported be high. To the best of our knowledge, th...

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Main Authors:	Ahmet Saracaloglu, Seniz Demiryürek, Sabit Kimyon, Alper Mete, Ebru Temiz, Gülper Nacarkahya, Betül Düzen, Oguzhan Saygili, Kıvanc Güngör, Abdullah Tuncay Demiryürek
Format:	Article
Language:	English
Published:	MDPI AG 2018-12-01
Series:	Proceedings
Subjects:	expression leukocyte pterygium Rho proteins
Online Access:	https://www.mdpi.com/2504-3900/2/25/1571

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spelling	doaj-53bdbf4b6ad24448a367d18aca8668592020-11-24T21:22:39ZengMDPI AGProceedings2504-39002018-12-01225157110.3390/proceedings2251571proceedings2251571Protein Expressions of the Small GTPase Rho Proteins in Pterygial Tissue and Leukocytes of Patients with PterygiumAhmet Saracaloglu0Seniz Demiryürek1Sabit Kimyon2Alper Mete3Ebru Temiz4Gülper Nacarkahya5Betül Düzen6Oguzhan Saygili7Kıvanc Güngör8Abdullah Tuncay Demiryürek9Department of Medical Pharmacology, Faculty of Medicine, University of Gaziantep, 27310 Gaziantep, TurkeyDepartment of Physiology, Faculty of Medicine, University of Gaziantep, 27310 Gaziantep, TurkeyDepartment of Ophthalmology, Faculty of Medicine, University of Gaziantep, 27310 Gaziantep, TurkeyDepartment of Ophthalmology, Faculty of Medicine, University of Gaziantep, 27310 Gaziantep, TurkeyDepartment of Medical Biochemistry, Faculty of Medicine, Harran University, 63290 Sanliurfa, TurkeyDepartment of Medical Biology, Faculty of Medicine, University of Gaziantep, 27310 Gaziantep, TurkeyOphthalmology Clinic, Gaziantep Dr. Ersin Arslan Training and Research Hospital, 27010 Gaziantep, TurkeyDepartment of Ophthalmology, Faculty of Medicine, University of Gaziantep, 27310 Gaziantep, TurkeyDepartment of Ophthalmology, Faculty of Medicine, University of Gaziantep, 27310 Gaziantep, TurkeyDepartment of Medical Pharmacology, Faculty of Medicine, University of Gaziantep, 27310 Gaziantep, TurkeyPterygium is a benign fibrovascular proliferation that develops from the conjunctiva and invades the cornea. The etiology of this disorder remains unclear. Current treatment of pterygium is surgical. The postoperative recurrence rate of pterygium is reported be high. To the best of our knowledge, these results are the first to demonstrate the contribution of proteins expressions of the small GTPase Rho proteins in patients with pterygium. Our data showed that leukocyte RhoA, RhoB, RhoD, and RhoE protein expressions were markedly elevated in primary pterygium. However, no significant modifications were noted in pterygial tissues.https://www.mdpi.com/2504-3900/2/25/1571expressionleukocytepterygiumRho proteins
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Ahmet Saracaloglu Seniz Demiryürek Sabit Kimyon Alper Mete Ebru Temiz Gülper Nacarkahya Betül Düzen Oguzhan Saygili Kıvanc Güngör Abdullah Tuncay Demiryürek
spellingShingle	Ahmet Saracaloglu Seniz Demiryürek Sabit Kimyon Alper Mete Ebru Temiz Gülper Nacarkahya Betül Düzen Oguzhan Saygili Kıvanc Güngör Abdullah Tuncay Demiryürek Protein Expressions of the Small GTPase Rho Proteins in Pterygial Tissue and Leukocytes of Patients with Pterygium Proceedings expression leukocyte pterygium Rho proteins
author_facet	Ahmet Saracaloglu Seniz Demiryürek Sabit Kimyon Alper Mete Ebru Temiz Gülper Nacarkahya Betül Düzen Oguzhan Saygili Kıvanc Güngör Abdullah Tuncay Demiryürek
author_sort	Ahmet Saracaloglu
title	Protein Expressions of the Small GTPase Rho Proteins in Pterygial Tissue and Leukocytes of Patients with Pterygium
title_short	Protein Expressions of the Small GTPase Rho Proteins in Pterygial Tissue and Leukocytes of Patients with Pterygium
title_full	Protein Expressions of the Small GTPase Rho Proteins in Pterygial Tissue and Leukocytes of Patients with Pterygium
title_fullStr	Protein Expressions of the Small GTPase Rho Proteins in Pterygial Tissue and Leukocytes of Patients with Pterygium
title_full_unstemmed	Protein Expressions of the Small GTPase Rho Proteins in Pterygial Tissue and Leukocytes of Patients with Pterygium
title_sort	protein expressions of the small gtpase rho proteins in pterygial tissue and leukocytes of patients with pterygium
publisher	MDPI AG
series	Proceedings
issn	2504-3900
publishDate	2018-12-01
description	Pterygium is a benign fibrovascular proliferation that develops from the conjunctiva and invades the cornea. The etiology of this disorder remains unclear. Current treatment of pterygium is surgical. The postoperative recurrence rate of pterygium is reported be high. To the best of our knowledge, these results are the first to demonstrate the contribution of proteins expressions of the small GTPase Rho proteins in patients with pterygium. Our data showed that leukocyte RhoA, RhoB, RhoD, and RhoE protein expressions were markedly elevated in primary pterygium. However, no significant modifications were noted in pterygial tissues.
topic	expression leukocyte pterygium Rho proteins
url	https://www.mdpi.com/2504-3900/2/25/1571
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Protein Expressions of the Small GTPase Rho Proteins in Pterygial Tissue and Leukocytes of Patients with Pterygium

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