An Innovative Bioceramic Bone Graft with Platelet-Rich Plasma for Rapid Bone Healing and Regeneration in a Rabbit Model
This study aimed to investigate the effect of combining an innovative bioceramic α-calcium sulfate hemihydrate (α-CSH, CaSO<sub>4</sub>⋅0.5H<sub>2</sub>O) bone graft and platelet-rich plasma (PRP) to accelerate bone healing and regeneration in a rabbit model. The bone graft m...
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MDPI AG
2021-06-01
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| Online Access: | https://www.mdpi.com/2076-3417/11/11/5271 |
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doaj-53c3fd3876a84d5893eed878b9d8bd9e2021-06-30T23:26:33ZengMDPI AGApplied Sciences2076-34172021-06-01115271527110.3390/app11115271An Innovative Bioceramic Bone Graft with Platelet-Rich Plasma for Rapid Bone Healing and Regeneration in a Rabbit ModelSyamsiah Syam0Chun-Wei Chang1Wen-Chien Lan2Keng-Liang Ou3Bai-Hung Huang4Yu-Yeong Lin5Takashi Saito6Hsin-Yu Tsai7Yen-Chun Chuo8Tzu-Sen Yang9Chung-Ming Liu10Ping-Jen Hou11Graduate Institute of Dental Science, College of Dentistry, China Medical University, Taichung 404, TaiwanDivision of Endodontics, Department of Dentistry, Taipei Medical University Hospital, Taipei 110, TaiwanDepartment of Oral Hygiene Care, Ching Kuo Institute of Management and Health, Keelung 203, TaiwanBiomedical Technology R & D Center, China Medical University Hospital, Taichung 404, TaiwanBiomedical Technology R & D Center, China Medical University Hospital, Taichung 404, TaiwanJ.U.S.T Dental Clinic, Taipei 114, TaiwanDivision of Clinical Cariology and Endodontology, Department of Oral Rehabilitation, School of Dentistry, Health Sciences University of Hokkaido, Hokkaido 061-0293, JapanDivision of Clinical Cariology and Endodontology, Department of Oral Rehabilitation, School of Dentistry, Health Sciences University of Hokkaido, Hokkaido 061-0293, JapanBiomedical Technology R & D Center, China Medical University Hospital, Taichung 404, TaiwanGraduate Institute of Biomedical Optomechatronics, College of Biomedical Engineering, Taipei Medical University, Taipei 110, TaiwanGraduate Institute of Dental Science, College of Dentistry, China Medical University, Taichung 404, TaiwanBiomedical Technology R & D Center, China Medical University Hospital, Taichung 404, TaiwanThis study aimed to investigate the effect of combining an innovative bioceramic α-calcium sulfate hemihydrate (α-CSH, CaSO<sub>4</sub>⋅0.5H<sub>2</sub>O) bone graft and platelet-rich plasma (PRP) to accelerate bone healing and regeneration in a rabbit model. The bone graft material was implanted bilaterally on rabbit’s artificially maxillary sinus defects: the right maxillary sinus received α-CSH, while α-CSH combine with PRP (α-CSH/PRP) was grafted in left site. The quantity and quality of bone formation after implantation were analyzed radiographically and histologically at 1, 2, and 3 weeks. The micro-computed tomographic results indicated that the bone density of sinus implanted with α-CSH increased and defect volume decreased most after 2 weeks. In histological analysis, both hematoxylin and eosin and Masson trichrome staining of α-CSH/PRP displays better bone healing and regeneration progress than α-CSH after 2 weeks implantation. Therefore, the innovative α-CSH combined with PRP was revealed to be useful in accelerating bone healing and regeneration for the successful defect treatment.https://www.mdpi.com/2076-3417/11/11/5271α-calcium sulfate hemihydratebioceramic bone graftplatelet-rich plasmabone healingbone regeneration |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Syamsiah Syam Chun-Wei Chang Wen-Chien Lan Keng-Liang Ou Bai-Hung Huang Yu-Yeong Lin Takashi Saito Hsin-Yu Tsai Yen-Chun Chuo Tzu-Sen Yang Chung-Ming Liu Ping-Jen Hou |
| spellingShingle |
Syamsiah Syam Chun-Wei Chang Wen-Chien Lan Keng-Liang Ou Bai-Hung Huang Yu-Yeong Lin Takashi Saito Hsin-Yu Tsai Yen-Chun Chuo Tzu-Sen Yang Chung-Ming Liu Ping-Jen Hou An Innovative Bioceramic Bone Graft with Platelet-Rich Plasma for Rapid Bone Healing and Regeneration in a Rabbit Model Applied Sciences α-calcium sulfate hemihydrate bioceramic bone graft platelet-rich plasma bone healing bone regeneration |
| author_facet |
Syamsiah Syam Chun-Wei Chang Wen-Chien Lan Keng-Liang Ou Bai-Hung Huang Yu-Yeong Lin Takashi Saito Hsin-Yu Tsai Yen-Chun Chuo Tzu-Sen Yang Chung-Ming Liu Ping-Jen Hou |
| author_sort |
Syamsiah Syam |
| title |
An Innovative Bioceramic Bone Graft with Platelet-Rich Plasma for Rapid Bone Healing and Regeneration in a Rabbit Model |
| title_short |
An Innovative Bioceramic Bone Graft with Platelet-Rich Plasma for Rapid Bone Healing and Regeneration in a Rabbit Model |
| title_full |
An Innovative Bioceramic Bone Graft with Platelet-Rich Plasma for Rapid Bone Healing and Regeneration in a Rabbit Model |
| title_fullStr |
An Innovative Bioceramic Bone Graft with Platelet-Rich Plasma for Rapid Bone Healing and Regeneration in a Rabbit Model |
| title_full_unstemmed |
An Innovative Bioceramic Bone Graft with Platelet-Rich Plasma for Rapid Bone Healing and Regeneration in a Rabbit Model |
| title_sort |
innovative bioceramic bone graft with platelet-rich plasma for rapid bone healing and regeneration in a rabbit model |
| publisher |
MDPI AG |
| series |
Applied Sciences |
| issn |
2076-3417 |
| publishDate |
2021-06-01 |
| description |
This study aimed to investigate the effect of combining an innovative bioceramic α-calcium sulfate hemihydrate (α-CSH, CaSO<sub>4</sub>⋅0.5H<sub>2</sub>O) bone graft and platelet-rich plasma (PRP) to accelerate bone healing and regeneration in a rabbit model. The bone graft material was implanted bilaterally on rabbit’s artificially maxillary sinus defects: the right maxillary sinus received α-CSH, while α-CSH combine with PRP (α-CSH/PRP) was grafted in left site. The quantity and quality of bone formation after implantation were analyzed radiographically and histologically at 1, 2, and 3 weeks. The micro-computed tomographic results indicated that the bone density of sinus implanted with α-CSH increased and defect volume decreased most after 2 weeks. In histological analysis, both hematoxylin and eosin and Masson trichrome staining of α-CSH/PRP displays better bone healing and regeneration progress than α-CSH after 2 weeks implantation. Therefore, the innovative α-CSH combined with PRP was revealed to be useful in accelerating bone healing and regeneration for the successful defect treatment. |
| topic |
α-calcium sulfate hemihydrate bioceramic bone graft platelet-rich plasma bone healing bone regeneration |
| url |
https://www.mdpi.com/2076-3417/11/11/5271 |
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